Search Results 1-20 of 526

  • Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study

    Sato Ryuhei , Handa Tomohiro , Matsumoto Hisako , Kubo Takeshi , Hirai Toyohiro

    … The correlations of cough intensity and frequency with potential predictor variables were tested using bivariate and multiple logistic regression analysis. … In multivariate analysis of patients with ILD, IIPs and the FSSG score were independently associated with both components of cough, and CPI tended to be independently associated with cough frequency. … Different clinical indices were associated with patient-reported cough intensity and frequency according to the subtype of ILD. …

    BMC Pulmonary Medicine (19), 2019-12-16

    IR 

  • LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia.

    TATSUMI Goichi , KAWAHARA Masahiro , YAMAMOTO Ryusuke , HISHIZAWA Masakatsu , KITO Katsuyuki , SUZUKI Takayoshi , TAKAORI-KONDO Akifumi , ANDOH Akira

    … Gene set enrichment analysis revealed that the GFI1-SE deletion impaired NCD38-induced programs related to granulocyte differentiation and the CEBPA network, but restored NCD38-suppressed programs related to erythroid development, GATA1 targets, and acute myeloid leukemia (AML) clusters including FAB subtype M6 and AML with myelodysplastic syndrome-related chromosomal abnormalities. …

    Leukemia, 2019-11-01

    IR 

  • Optical Recording of Action Potentials in Human Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Generated from Long QT Syndrome Type 1 Patients

    Takaki Tadashi , Inagaki Azusa , Chonabayashi Kazuhisa , Inoue Keiji , Miki Kenji , Ohno Seiko , Makiyama Takeru , Horie Minoru , Yoshida Yoshinori

    … Although optical recordings using membrane potential dyes to monitor action potentials (APs) were reported, no study has investigated the disease phenotypes of cardiac channelopathy in association with the cardiac subtype at the single-cell level. … Single-cell analysis using a fast-responding dye confirmed that ventricular cells were the dominant subtype (control-iPSC-CMs: 98%, 88%, 91%; …

    Stem Cells International (2019), 2019-03-06

    IR 

  • Maximum Walking Speed at Discharge Could Be a Prognostic Factor for Vascular Events in Patients With Mild Stroke: A Cohort Study

    Kawajiri Hiroyuki , Mishina Hiromi , Asano Sho , Kono Yuji , Hayashi Hironori , Niwa Jun-ichi , Doyu Manabu , Kimura Shinya , Yamada Sumio

    … During hospitalization, known vascular risk factors such as previous history of vascular events, stroke subtype, white matter lesions, and ankle-brachial index were assessed. … After multivariate analysis, cerebral white matter lesions of periventricular hyperintensity (PVH) (grade=3; …

    Archives of Physical Medicine and Rehabilitation 100(2), 230-238, 2019-02

    IR 

  • Laparoscopic diagnosis and treatment of omental pregnancy following emergency contraception intake  [in Japanese]

    Andoh Yuriko , Ohnishi Kento , Ogata Yuri , Gota Tomoko , Sho Hibun , Nakanishi Misao , Sadatsuki Miyuki , Oishi Hajime

    … Omental pregnancy is a subtype of abdominal pregnancy, which accounts for <1% of all ectopic pregnancies. … Histopathological analysis confirmed the diagnosis of omental pregnancy. …

    JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY 35(2), 377-382, 2019

    J-STAGE 

  • Understanding of boundary conditions imposed at multiple outlets in computational haemodynamic analysis of cerebral aneurysm

    Shimano Kenjiro , Serigano Shota , Ikeda Naoki , Yuchi Tomoki , Shiratori Suguru , Nagano Hideaki

    … <p>Computational fluid dynamics (CFD) is considered to be a promising tool for haemodynamic analysis of the intracranial aneurysm. … For accurate quantification of the haemodynamic state in the aneurysm, it is crucial to incorporate the physiologically correct flow splitting ratio in CFD analysis by means of accurate specification of pressure or flow rate at the outlets. …

    Journal of Biorheology 33(2), 32-42, 2019

    J-STAGE 

  • Trends in Transmitted Drug Resistance and Prevalence of Non-B Subtype in Newly Diagnosed Individuals with HIV-1 in the Tokai Area  [in Japanese]

    OKAZAKI Reiko , IKEGAYA Takeshi , ITO Masato , MATSUMOTO Takeshi , KURAI Hanako , KAWABATA Atsushi , HASHIBA Chieko , NAKAHATA Masashi , KOGURE Ayumi , HATTORI Junko , IBE Shiro , SHIGEMI Urara , IMAHASHI Mayumi , IWATANI Yasumasa , SUGIURA Wataru , YOSHIMURA Kazuhisa , HACHIYA Atsuko , YOKOMAKU Yoshiyuki , MATSUDA Masakazu , KUBOTA Mai , YANO Kunio , TSURUMI Hisashi , OKUMURA Nobumasa , TANIGUCHI Haruki , SHICHI Daisuke

    … Non-B subtype infections accounted for 11.2% of new diagnoses in the Tokai area. … Most individuals were infected with CRF01_AE, followed by subtype C and CRF02_AG, A, F, G and BF recombinant virus. … The estimated location of infection in Japan was most observed in the CRF01_AE, subtype C and CRF01_ AG. … The molecular phylogenic analysis revealed that 8 of the 12 individuals infected with HIV-1s CRF02_AG belong to the same transmission cluster. …

    Kansenshogaku Zasshi 93(3), 298-305, 2019

    J-STAGE 

  • Comprehensive genetic analyses of relapsed B-cell precursor acute lymphoblastic leukemia in children

    Kubo Kaori , Sasaki Shinya , Terui Kiminori , Ito Etsuro , Kudo Ko , Toki Tsutomu , Kanezaki Rika , Ikeda Fumika , Ito Tatsuya , Kobayashi Akie , Sato Tomohiko , Kamio Takuya

    … Copy number variation analysis of <i>IKZF1</i>, a gene for which deletions are associated with increased relapse risk, revealed deletions at both diagnosis and at relapse (n=5). … Targeted RNA sequencing identified a rare subtype of BCP-ALL with a <i>NUP214-ABL1</i> … Together with recent reports that RAS mutations confer sensitivity to MEK inhibitors, these results suggest that comprehensive genetic analysis will contribute to the optimal treatment for relapsed BCP-ALL. …

    Hirosaki Medical Journal 70(1), 13-23, 2019

    IR  J-STAGE 

  • Human Leukocyte Antigen-Associated HIV-1 CRF02_AG <i>gag</i> and <i>vif</i> Polymorphisms in Ghana

    Adusei-Poku Mildred A. , Shiino Teiichiro , Kawana-Tachikawa Ai , Ishikawa Koichi , Ampofo William K. , Matano Tetsuro , Matsuoka Saori , Bonney Evelyn Y. , Abana Christopher Z. , Duker Ewurabena O. , Nii-Trebi Nicholas I. , Ofori Sampson B. , Mizutani Taketoshi , Ishizaka Aya

    … In the present study, we investigated the HLA-associated mutations in HIV-1 subtype CRF02_AG prevailing in Ghana, Western Africa. … Phylogeny analysis revealed that 200 (81.3%) individuals were infected with HIV-1 CRF02_AG. … The analysis found HLA-associated HIV-1 CRF02_AG non-synonymous polymorphisms at 19 sites; …

    Japanese Journal of Infectious Diseases 72(6), 374-380, 2019

    J-STAGE 

  • Yogurt-sourced probiotic bacteria alleviate shrimp tropomyosin-induced allergic mucosal disorders, potentially through microbiota and metabolism modifications

    Fu Linglin , Fu Shujie , Wang Chong , Xie Menghua , Wang Yanbo

    … The allergic mucosal disorders were assessed by histological analysis and ELISAs. … Statistical analysis suggested the metabolites aspartate and arginine, as well as several commensal flora groups, to be the critical mediators in the process.</p><p><i>Conclusions:</i> …

    Allergology International 68(4), 506-514, 2019

    J-STAGE 

  • Severity of Liver Fibrosis in Biliary Atresia With Ductal Plate Malformation  [in Japanese]

    Obayashi Juma , Koike Junki , Furuta Shigeyuki , Tanaka Kunihide , Nagae Hideki , Kitagawa Hiroaki

    … <p><i>Purpose</i>: Several investigators have reported that ductal plate malformation (DPM) in the liver is characteristic of persistent embryonal ductular strictures and the embryonic subtype of biliary atresia (BA). … Regression analysis was carried out with the significance level set at p <0.05.</p><p><i>Results</i>: There were nine patients in Group A and 23 patients in Group B. …

    Journal of the Japanese Society of Pediatric Surgeons 55(6), 1061-1065, 2019

    J-STAGE 

  • Slaughterhouse survey for detection of bovine viral diarrhea infection among beef cattle in Kyushu, Japan

    AGAH Mohammad Aref , EL DAOUS Hala , MAI Thi Ngan , NGUYEN Thi Huyen , ISODA Norikazu , SAKODA Yoshihiro , NORIMINE Junzo , SEKIGUCHI Satoshi , NOTSU Kosuke , EL-KHAIAT Heba M. , ARIKAWA Genki , KUBO Meiko , MITOMA Shuya , OKABAYASHI Tamaki , MEKATA Hirohisa , ELHANAFY Eslam

    … Phylogenetic analysis based on the 5'-UTR revealed that the two positive samples were grouped into the same subtype BVDV-1b in the BVDV-1 genotype, but the infected cattle belonged to two different farms. …

    Journal of Veterinary Medical Science 81(10), 1450-1454, 2019

    J-STAGE 

  • The differential diagnosis of classical myeloproliferative neoplasms (MPN): the updated WHO criteria

    KVASNICKA Hans Michael

    … The diagnostic approach proposed by the World Health Organization (WHO) uses clinical features, peripheral blood counts and smear analysis, bone marrow (BM) morphology, karyotype and molecular genetic tests to classify MPN subtypes. … JAK2 mutations are detected in more than 90% of patients with PV and are therefore used as highly sensitive clonal marker in this subtype. …

    Rinsho Ketsueki 60(9), 1166-1175, 2019

    J-STAGE 

  • Clinicopathological analysis of sinonasal malignant lymphoma in an HTLV-1 endemic area in Japan -special focus on primary sinonasal diffuse large B-cell lymphoma-

    Murakami Daisuke , Miyashita Kaname , Koyama Tetsuya , Omori Hirofumi , Miyamoto Yusuke , Sawatsubashi Motohiro , Nakagawa Takashi

    … The histological subtype of sinonasal lymphoma was diffuse large B-cell lymphoma (DLBCL) in all six tumors. …

    Journal of Clinical and Experimental Hematopathology 59(3), 101-107, 2019

    J-STAGE 

  • Evaluation of Accuracy of Side Surgical Margins for Basal Cell Carcinoma Determined as Dermato-Oncologists  [in Japanese]

    Saito Shintaro , Nakamura Yasuhiro , Teramoto Yukiko , Asami Yuri , Matsuya Taisuke , Yasuda Masahito , Ishikawa Osamu , Yamamoto Akifumi , Araki Ryuichiro

    … Subgroup analysis indicates that high ENMRs will be obtained with 2-mm in low-risk group and 3-mm side margins in tumors with poorly-defined clinical borders, non-pigmented subtype and aggressive clinical subtype.</p> …

    The Japanese Journal of Dermatology 129(10), 2157-2164, 2019

    J-STAGE 

  • Analysis of eosinophil granule proteins in ECRS

    Tsuda Takeshi , Maeda Yohei , Hayama Masaki , Takeda Kazuya , Inohara Hidenori

    … <p>Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis (CRS) that is characterized by eosinophilic nasal polyposis. … Pathway analysis revealed that the major canonical pathway affected by EDN stimulation was "regulation of the epithelial–mesenchymal transition (EMT) pathway"; …

    Journal of Japan Society of Immunology & Allergology in Otolaryngology 37(3), 223-228, 2019

    J-STAGE  Ichushi Web 

  • Different Influences of Statin Treatment in Preventing At-Risk Stroke Subtypes: A Post Hoc Analysis of J-STARS

    Hosomi Naohisa , Minematsu Kazuo , Uchiyama Shinichiro , Matsumoto Masayasu , for J-STARS collaborators , Kitagawa Kazuo , Nagai Yoji , Nakagawa Yoko , Aoki Shiro , Nezu Tomohisa , Kagimura Tatsuo , Maruyama Hirofumi , Origasa Hideki

    … <p><b>Aims: </b>To understand the different influences of statins on the incidence rate of each stroke subtype in association with low-density lipoprotein (LDL) cholesterol levels, we performed a post hoc analysis on the data from the Japan Statin Treatment Against Recurrent Stroke (J-STARS) study.<b> …

    Journal of Atherosclerosis and Thrombosis, 2019

    J-STAGE 

  • <i>BCL2</i>, <i>BCL6</i>, and <i>MYC</i>-positive intravascular large B-cell lymphoma presenting with bilateral adrenal gland lesions  [in Japanese]

    OGASAWARA Toshie , EBATA Nozomiko , HAMASAKI Julia , MARSHALL Shoko , KAWAUCHI Kiyotaka , OHSHIMA Koichi , MORI Naoki , SAKURA Hiroshi

    … The leading histopathological subtype of adrenal lymphoma is diffuse large B-cell lymphoma, and intravascular large B-cell lymphoma (IVLBCL) is rare. … Tumor cells were positive for CD20 and MUM-1 but not for CD10 on immunostaining, suggesting non-germinal center B-cell subtype lymphoma. … The chromosomal analysis revealed complex karyotypic abnormalities without a rearrangement of <i>BCL2</i> … using FISH analysis. …

    Rinsho Ketsueki 60(6), 570-576, 2019

    J-STAGE  Ichushi Web 

  • Rapid and Long-term Response of Pulmonary Pleomorphic Carcinoma to Nivolumab

    Senoo Satoru , Hotta Katsuyuki , Maeda Yoshinobu , Kiura Katsuyuki , Ninomiya Takashi , Makimoto Go , Nishii Kazuya , Kano Hirohisa , Watanabe Hiromi , Hata Yusuke , Kubo Toshio , Tanaka Takehiro

    … <p>Pulmonary pleomorphic carcinoma (PPC) is a rare very aggressive subtype of non-small cell lung cancer. … An immunohistochemical analysis revealed numerous PD-1<sup>+</sup>, CD68<sup>+</sup> …

    Internal Medicine 58(7), 985-989, 2019

    J-STAGE 

  • Characterization of a novel reassortant H7N3 highly pathogenic avian influenza virus isolated from a poultry meat product taken on a passenger flight to Japan

    SHIBATA Akihiro , UCHIDA Yuko , SAITO Takehiko , SAKODA Yoshihiro , OSAKA Hiroyuki , HARADA Rieko , OKAMATSU Masatoshi , MATSUNO Keita , ARITA Tomoko , SUZUKI Yasushi , SHIRAKURA Masayuki , ODAGIRI Takato , TAKEMAE Nobuhiro

    … Sequencing analysis revealed that the H7N3 isolate, A/duck/Japan/AQ-HE30-1/2018 (Dk/HE30-1) (H7N3), was a reassortant highly pathogenic avian influenza virus (HPAIV) that contained the haemagglutinin (HA) gene of Chinese H7N9 HPAIV. …

    Journal of Veterinary Medical Science 81(3), 444-448, 2019

    J-STAGE  Ichushi Web 

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