Search Results 1-20 of 46

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  • Development of a Novel Milling System Using Supercritical Carbon Dioxide for Improvement of Dissolution Characteristics of Water-Poorly Soluble Drugs

    Fern Jennifer Chia Wee , Nakamura Hideya , Watano Satoru

    … <p>The aim of this study is to develop a novel milling system using supercritical carbon dioxide (SC-CO<sub>2</sub>) for the improvement of dissolution characteristics of water-poorly soluble drugs. … SC-CO<sub>2</sub> … possesses high potential in the application of nanotechnology, due to the attractive properties of SC-CO<sub>2</sub> … fluid such as cheap, inert and non-polluting. …

    Chemical and Pharmaceutical Bulletin 64(12), 1720-1725, 2016

    J-STAGE Ichushi Web

  • Development of Advanced Freeze Granulation by Supercritical Fluid and its Application to Dry Powder Inhalation

    Sakamoto Yohei , Nakamura Hideya , Watano Satoru

    … Granulation of drug particles for dry powder inhalation was conducted by means of a novel granulation method, named as Advanced Freeze Granulation by Supercritical Fluid. … In this method, drug particles were micronized and granulated by the following steps: 1) drug particles were micronized by beads milling in a supercritical carbon dioxide (SC-CO<sub>2</sub>); …

    Journal of the Society of Powder Technology, Japan 52(6), 330-336, 2015



    Abdullah Rand , Agranat Vladimir , Malin Michael , Pioro Igor

    … Also, Generation-IV nuclear technology will include SuperCritical-Pressure (SCP) reactor coolants (helium and water) and/or SCP working fluids in power cycles (carbon dioxide, helium and water). … Due to this reliable and accurate prediction methods for heat transfer in SC Fluids (SCFs) should be developed and verified. …

    The Proceedings of the International Conference on Nuclear Engineering (ICONE) 2015.23(0), _ICONE23-1-_ICONE23-1, 2015


  • Supercritical Fluid Extraction of "Koku" Enhancing Compounds from Fish and Fishery by-Products

    Shibata Munehisa , Onodera Kei , Kumagai Momochika , Shah A.K.M. Azad , Ogasawara Masashi , Kurihara Hideyuki , Okino Tatsufumi , Takahashi Koretaro

    … The potential of supercritical carbon dioxide (SC-CO<sub>2</sub>) extraction of "koku" enhancing compounds from dried herring fillet ("Migaki-nishin" in Japanese) and sturgeon liver was explored. … "Koku" enhancing compounds from a water-soluble extract and a mixed water miscible SC-CO<sub>2</sub> … Results showed that only select compounds were found in the mixed water miscible SC-CO<sub>2</sub> …

    Food Science and Technology Research 20(6), 1199-1205, 2014


  • Removal of Oligomers from Polyethylene Terephthalate Resins by Supercritical Carbon Dioxide Extraction for Improving Properties of PET Films

    Inagaki Jun , Kawase Fumio , Sasaki Mitsuru , Goto Motonobu , Ito Katsuya

    … To remove this component from PET resins, extraction experiments of PET resins with supercritical carbon dioxide (sc-CO<sub>2</sub>) were carried out using a semi-batch apparatus under various temperatures and extraction times. …

    Seikei-Kakou 25(11), 547-551, 2013


  • 21201 Filling Technology of Fine Holes by Cu Electroplating using Supercritical Carbon Dioxide Emulsion  [in Japanese]

    Sone Masato

    … This paper reports an electroplating method with supercritical carbon dioxide (sc-C02) emulsion, denoted as "Supercritical Nano Plating (SNP)" … The reaction is carried out in an emulsion of sc-C0_2 in copper-sulfate-based electrolyte with surfactants. … It was reported that Ni film obtained by SNP is uniform and without pinhole, because sc-C0_2 has low viscosity and compatibility of hydrogen. …

    The Proceedings of Conference of Kanto Branch 2013.19(0), 535-536, 2013


  • Acoustic emission monitoring of hydraulic fracturing laboratory experiment with supercritical and liquid CO2

    Ishida Tsuyoshi , Aoyagi Kazuhei , Niwa Tomoya , Chen Youqing , Murata Sumihiko , Chen Qu , Nakayama Yoshiki

    … CO2 usually becomes supercritical (SC-CO2) at depths greater than 1, 000 m, while it is liquid (L-CO2) at low temperatures. … The viscosity of L-CO2 is one order lower than that of normal liquid water, and that of SC-CO2 is much lower still. …

    Geophysical Research Letters (39), 2012-08-29


  • Development of functionality material for supplement by supercritical crystallization and extraction method  [in Japanese]

    Honjo Masatoshi

    Pharmaceutical bulletin of Fukuoka University 11(35), 41-50, 2011-03

    IR Ichushi Web


    Richards G. , Shelegov A. S. , Kirillov P. L. , Pioro I. L. , Harvel G.

    … Experimental data on SuperCritical-Water (SCW) cooled bundles are very limited. … However, SuperCritical Water-cooled nuclear Reactors (SCWRs) cannot be designed without such data. … Therefore, as a preliminary approach experiments in SCWcooled bare tubes and in bundles cooled with SC modeling fluids can be used. … One of the SC modeling fluids typically used is Freon-12 (R-12) where the critical pressure is 4.136 MPa and the critical temperature is 111.97℃. …

    The Proceedings of the International Conference on Nuclear Engineering (ICONE) 2011.19(0), _ICONE1943-_ICONE1943, 2011


  • Solubility Estimation of High-value Natural Products in Supercritical CO_2 Based on Solubility Parameter  [in Japanese]

    SATO Megumi , TAKEDA Keisuke , OTA Masaki , SATO Yoshiyuki , INOMATA Hiroshi

    溶解度パラメータ(SP値)に基づく希少天然成分の溶解度定量化を目的とし,flavone,6-methoxyflavoneの2種のフラボノイドを対象とした実験的検討を行った.まず,各種有機溶媒を用いた溶解度測定実験により,溶解度が最大となるSP値を求めたところ,いずれの溶質もSP値はおよそ19 MPa<sup>0.5</sup>と推定された.一方,Fedors法およびHans …

    KAGAKU KOGAKU RONBUNSHU 36(5), 466-471, 2010-11-20

    J-STAGE References (22)

  • A-13 Numerical Analysis of Super-critical Carbon-dioxide Flows in a Centrifugal Compressor  [in Japanese]

    HIMENO Takehiro , TAN Takayuki , WATANABE Toshinori , INOUE Chihiro , UTAMURA Motoaki , HASUIKE Hiroshi

    … A new type of closed-cycle gas turbine utilizing supercritical carbon-dioxide (SC-CO_2) as a working fluid was proposed and has been studied. … Since the thermo-fluid properties of SC-CO_2 near the critical point would change drastically by the slight change in temperature or pressure, the behavior of flow in the compressor for the SC-CO_2 gas turbine is different from that of perfect gas. …

    ガスタービン定期講演会講演論文集 (38), 113-118, 2010-10-20

  • Step Coverage Quality of Cu Films by Supercritical Fluid Deposition Compared with Chemical Vapor Deposition

    Takeshi Momose , Masakazu Sugiyama , Eiichi Kondoh , Yukihiro Shimogaki

    … Feasibility of step coverage (SC) by supercritical fluid deposition (SCFD) of Cu was evaluated using a finite element method (FEM) simulation with experimentally estimated kinetics and transport properties of the precursor. … This SC by Cu-SCFD was compared with that by chemical vapor deposition (CVD). … SCFD showed superior SC, especially for ultra narrow features less than 1 μm wide, although CVD has a higher diffusion coefficient. …

    Jpn J Appl Phys 49(5), 05FF01-05FF01-6, 2010-05-25


  • Supercritical Fluid-assisted Electroless Copper Plating of Aramid Film:The Influence of Surface Treatment

    Belmas Magali , Tabata Isao , Hisada Kenji , Hori Teruo

    … A process of metalizing aramid fibers using supercritical CO<sub>2</sub> … (sc-CO<sub>2</sub>) followed by electroless copper plating has been developed recently. … In response to such requirements, we developed in our present study a method of plating aramid film after impregnating it with organometallic complexes using sc-CO<sub>2</sub> …

    Sen'i Gakkaishi 66(9), 215-221, 2010


  • 0605 Numerical Analysis of Super-critical Carbon-dioxide Flows in a Centrifugal Compressor  [in Japanese]

    Himeno Takehiro , Tan Takayuki , Watanabe Toshinori , Inoue Chihiro , Utamura Motoaki , Hasuike Hiroshi

    … A new type of closed-cycle gas turbine which uses supercritical carbon-dioxide (SC-CO_2) as a working fluid was proposed and has been studied in these days. … It is supposed that the behavior of SC-CO_2 will be different from that of perfect gas because the thermal properties of SC-CO_2 will change dramatically according to the slight changes of temperature or pressure in compressors. …

    The Proceedings of the Fluids engineering conference 2010(0), 189-190, 2010


  • Design of nano drug for dry powder inhalation via supercritical carbon dioxide  [in Japanese]

    WATANO Satoru

    筆者らは,微粒子の生成と造粒(凝集)を単一のプロセスで同時に行うことが可能な,超臨界凍結造粒法(FG-SCF)を開発した.本法は,超臨界二酸化炭素が大気に開放される過程でJoule-Thomson効果(断熱膨張)によって生じる急激な温度降下を利用した新しい造粒方法であり,ポーラスな微粒子の凝集体を形成することができる.<BR>本稿では,超臨界二酸化炭素を用いた薬物微粒子の設計法と,粉末 …

    Drug Delivery System 24(5), 492-498, 2009-10-09

    J-STAGE Ichushi Web References (13)

  • Prediction of the Solubility of Aromatic Compounds from Brazilian Roasted Coffee(2-Methylpyrazine ; 2-Furfurylalcohol ; 2,5-Dimethylpyrazine ; γ-Butyrolactone and 2-Furfurylacetate) in SC-CO_2

    DE OLIVEIRA Alessandra Lopes , EBERLIN Marcos Nogueira , CABRAL Fernando Antonio

    … The solubility data for a mixture of five compounds present in the aromatic fraction of Brazilian roasted coffee (2-methylpyrazine, 2-furfurylalcohol, 2,5-dimethylpyrazine, <I>γ</I>-butyrolactone and 2-furfurylacetate) in supercritical carbon dioxide (SC-CO<SUB>2</SUB>) were determined at pressures from 250 to 300 bar and temperatures from 40 to 70°C. … The solubilities of each of these five pure compounds in SC-CO<SUB>2</SUB> …

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 42(4), 219-230, 2009-07-01

    J-STAGE References (35)

  • Flow Visualization and Numerical Simulation of T-Junction Mixing of High-Temperature High-Pressure Water

    MASUDA Yoshio , AIZAWA Takafumi , SUZUKI Akira

    Fluid flow at the T-junction of a model of a supercritical water microreactor is studied experimentally and numerically. … SC/Tetra is used as the computational fluid dynamics software and three-dimensional calculation is performed. …


    J-STAGE References (9) Cited by (1)

  • Imprinting Effect Inducing Crystallization of Uracil on Polymer Membrane Prepared in Supercritical CO_2 Phase Inversion

    ZHANG Quanqiu , KOBAYASHI Takaomi

    … Crystallization of uracil (URA) induced by the imprinting effect is observed when a poly(acrylonitrile-co-methacrylic acid) membrane has been prepared in supercritical CO<SUB>2</SUB> … Effects of organic solvents on the URA-imprinted membrane are examined for the membrane was prepared in supercritical CO<SUB>2</SUB> … fluid. … Evidence shows that supercritical CO<SUB>2</SUB> …


    J-STAGE References (17)

  • Polarity Effect in DC Breakdown Voltage Characteristics of Pressurized Carbon Dioxide up to Supercritical Conditions

    Kiyan Tsuyoshi , Takade Maya , Namihira Takao , Hara Masanori , Sasaki Mitsuru , Goto Motonobu , Akiyama Hidenori , キヤン ツヨシ , タカデ マヤ , ナミヒラ タカオ , ハラ マサノリ , ササキ ミツル , ゴトウ モトノブ , アキヤマ ヒデノリ , 喜屋武 毅 , 高出 麻耶 , 浪平 隆男 , 佐々木 満 , 後藤 元信 , 秋山 秀典

    … This paper deals with the effect of the polarity and gap geometry on dc breakdown voltage characteristics of a pointto-plane gap in supercritical carbon dioxide (SC CO2) that is required to design a plasma reactor. … In the experiments, the gap width d and the curvature radius of the point tip r were changed in the range of 80 to 300 μm and 50 to 170 μm respectively,and the CO2 state was controlled within the gas, liquid, and SC phases. …

    IEEE transactions on plasma science 36(3, part2), 821-827, 2008-06

    IR DOI Cited by (4)

  • Negative DC Prebreakdown Phenomena and Breakdown-Voltage Characteristics of Pressurized Carbon Dioxide up to Supercritical Conditions

    Kiyan Tsuyoshi , Uemura Akihiro , Roy Bhupesh C. , Namihira Takao , Hara Masanori , Sasaki Mitsuru , Goto Motonobu , Akiyama Hidenori , キヤン ツヨシ , ウエムラ アキヒロ , ナミヒラ タカオ , ハラ マサノリ , ササキ ミツル , ゴトウ モトノブ , アキヤマ ヒデノリ , 喜屋武 毅 , 上村 彰博 , 浪平 隆男 , 佐々木 満 , 後藤 元信 , 秋山 秀典

    … This paper deals with the experimental results on prebreakdown phenomena and breakdown voltage characteristics of a negative dc point-to-plane gap in-compressed carbon dioxide up to the supercritical pressure as the first step to develop a plasma reactor with supercritical carbon dioxide. … The experimental results show the following: 1) corona discharge preceding complete breakdown is observed more clearly in liquid and supercritical fluid than in gas; …

    IEEE TRANSACTIONS ON PLASMA SCIENCE 35(3), 656-662, 2007-06

    IR DOI Cited by (3)

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