Search Results 1-20 of 5969

  • Don't rely too much on trees: Evidence from flood mitigation in China

    Tembata Kaori , Yamamoto Yuki , Yamamoto Masashi , Matsumoto Ken'ichi

    … To the best of the authors' knowledge, this study is the first to show that the type of forest is critical for mitigating floods in a rigorous econometric way (survival analysis) spanning numerous areas of interest. …

    Science of The Total Environment (732), 138410, 2020-05-07

    IR 

  • High-flow nasal cannula therapy for acute respiratory failure in patients with interstitial pneumonia: a retrospective observational study

    Omote Norihito , Matsuda Naoyuki , Hashimoto Naozumi , Nishida Kazuki , Sakamoto Koji , Ando Akira , Nakahara Yoshio , Nishikimi Mitsuaki , Higashi Michiko , Matsui Shigeyuki , Hasegawa Yoshinori

    … High-flow nasal cannula (HFNC) oxygen is a therapy that has demonstrated survival benefits in acute respiratory failure (ARF). … HFNC therapy was a significant determinant of 30-day mortality in univariate analysis, and was confirmed to be an independent significant determinant of 30-day mortality in multivariate analysis (odds ratio, 0.148; …

    Nagoya Journal of Medical Science 82(2), 301-313, 2020-05

    IR  DOI 

  • Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma

    Matsumoto Yuji , Ichikawa Tomotsugu , Kurozumi Kazuhiko , Otani Yoshihiro , Fujimura Atsushi , Fujii Kentaro , Tomita Yusuke , Hattori Yasuhiko , Uneda Atsuhito , Tsuboi Nobushige , Kaneda Keisuke , Makino Keigo , Date Isao

    … We identified oncostatin M receptor (OSMR) as a key ANXA2 target gene in GBM utilizing microarray analysis and hierarchical clustering analysis of the Ivy Glioblastoma Atlas Project and The Cancer Genome Atlas datasets. … Mice bearing ANXA2-overexpressing GBM exhibited shorter survival times compared with control tumor-bearing mice, whereas OSMR knockdown increased the survival time and diminished ANXA2-mediated tumor invasion, angiogenesis, and growth. …

    Acta Neuropathologica Communications 8(1), 42, 2020-04-05

    IR 

  • EFFECTIVENESS OF COOPERATIVE TREATMENT USING COMMUNITY MEDICAL SYSTEMS AND HEALTHCARE SERVICES FOR SECOND-LINE THERAPY IN ADVANCED UROTHELIAL CANCER PATIENTS : IMPACT ON SURVIVAL  [in Japanese]

    宮田 康好 , 松尾 朋博 , 光成 健輔 , 大庭 康司郎 , 酒井 英樹

    … We observed that the overall survival after the second-line treatment was significantly longer in the cooperative group than in the other two groups, with multivariate analyses confirming cooperative treatment as a significant factor for better prognosis (P=0.005). … Multivariate analysis showed that cooperative treatment was particularly beneficial for female patients ≥75 years of age, and patients with status 2 performance. …

    泌尿器科紀要 = Acta urologica Japonica 66(4), 107-113, 2020-04

    IR  DOI 

  • Mucinous Carcinoma of the Breast: Clinicopathological Features and Long-term Prognosis in Comparison with Invasive Ductal Cancer; A Single Hospital's 30+-Year Experience

    Isozaki Hiroshi , Yamamoto Yasuhisa , Sakai Kunihiko , Sho Tatuo , Ishihara Kiyohiro , Murakami Shigeki , Matsumoto Sasau , Takama Takehiro

    … We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. … The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). …

    Acta Medica Okayama 74(2), 137-143, 2020-04

    IR  DOI 

  • How do socio-ecological factors shape culture? Understanding the process of micro-macro interactions

    Uchida Yukiko , Takemura Kosuke , Fukushima Shintaro

    … that are adaptive for survival in each environment. … In this paper, we conceptually review the works examining various macro sharing processes for cultural values, and focus on the use of multilevel analysis in elucidating the effect of both macro and individual level factors. …

    Current opinion in psychology (32), 115-119, 2020-04

    IR 

  • Roles of FoxP3-positive Regulatory T Cells in Lymphoid Follicle Formation Associated with Lung Squamous Cell Carcinoma

    Morimichi Nishihira , Yoshimasa Nakazato , Ikuma Wakamatsu , Sumiko Maeda , Takashi Inoue , Osamu Araki , Yoko Karube , Masayuki Chida

    … However, the roles of FoxP3⁺/CD4⁺/CD25⁺-regulatory T cells(Tregs)in formation of lymphoid follicles as well as survival remain unclear.Methods:Specimens obtained from patients during resection of lung SCC were examined for lymphoid follicle formation and subjected to immunohistochemistry analysis for the presence of TILs.Results:The appearance of Tregs was correlated with lymphoid follicle formation(p=0.001). …

    Dokkyo Journal of Medical Sciences 47(1), 9-13, 2020-03-25

    IR 

  • Characterization of tick-borne encephalitis virus isolated from a tick in central Hokkaido in 2017

    Takahashi Yuji , Kobayashi Shintaro , Ishizuka Mariko , Hirano Minato , Muto Memi , Nishiyama Shoko , Kariwa Hiroaki , Yoshii Kentaro

    … Sequence analysis revealed that the isolated strain belonged to the Far Eastern subtype of TBEV and was classified in a different subcluster from Oshima 5-10, which had previously been isolated in southern Hokkaido. … The mortality rate of mice infected intracerebrally with each virus was similar, but the survival time of mice inoculated with Sapporo-17-Io1 was significantly longer than that of mice inoculated with Oshima 5-10. …

    Journal of General Virology 101(5), 497-509, 2020-03-05

    IR 

  • Clinical Implications of Naples Prognostic Score in Patients with Resected Pancreatic Cancer

    Nakagawa Nobuhiko , Yamada Suguru , Sonohara Fuminori , Takami Hideki , Hayashi Masamichi , Kanda Mitsuro , Kobayashi Daisuke , Tanaka Chie , Nakayama Goro , Koike Masahiko , Fujiwara Michitaka , Kodera Yasuhiro

    … The Naples prognostic score (NPS) consists of the serum albumin level, total cholesterol level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and could be useful for predicting survival. … Clinicopathological characteristics, surgical outcomes, and long-term survival were compared, and multivariate analysis of overall survival was conducted. …

    Annals of Surgical Oncology 27(3), 887-895, 2020-03

    IR 

  • On the Survival of Higher Education as an Organization: Self-discipline  [in Japanese]

    藤村 正司

    … The main findings of the analysis are as follows.Firstly, this paper identifies a principal-agent relationship not only between government and national universities, but also within NUCs. …

    大学論集 (52), 1-17, 2020-03

    IR  DOI 

  • Age, Symptomatic Metastatic Disease, and Malignant Pleural Effusion as Predictors of Poor Prognosis in Patients with Differentiated Thyroid Carcinoma Treated with Lenvatinib.

    Nakashima Yomi , Ando Takao , Nozaki Aya , Ito Ayako , Horie Ichiro , Imaizumi Misa , Usa Toshiro , Kawakami Atsushi

    … The patients who died were older than the survivors (76.7±6.5 vs. 68.6±6.6 yrs, p=0.03).Malignant pleural effusion (p=0.017) and symptomatic metastatic disease (SMD) (p=0.039) were associated with death in a Kaplan-Meier survival analysis. …

    Acta medica Nagasakiensia 63(2), 71-77, 2020-03

    IR 

  • System-Based Differential Gene Network Analysis for Characterizing a Sample-Specific Subnetwork

    Tanaka Yoshihisa , Tamada Yoshinori , Ikeguchi Marie , Yamashita Fumiyoshi , Okuno Yasushi

    … However, the existing gene network analysis relies on having a sufficient number of samples and is required to handle a huge number of nodes and estimated edges, which remain difficult to interpret, especially in discovering the clinically relevant portions of the network. … Furthermore, we found that the sample-specific ECv patterns of this EMT network can characterize the survival of lung cancer patients. …

    Biomolecules 10(2), 2020-02

    IR 

  • A nationwide, multi-center, retrospective study of symptomatic small bowel stricture in patients with Crohn's disease.

    BAMBA Shigeki , SAKEMI Ryosuke , FUJII Toshimitsu , TAKEDA Teruyuki , FUJIOKA Shin , TAKENAKA Kento , KITAMOTO Hiroki , UMEZAWA Shotaro , SAKURABA Hirotake , INOKUCHI Toshihiro , FUKATA Norimasa , MIZUNO Shinta , YAMASHITA Masaki , SHINZAKI Shinichiro , TANAKA Hiroki , TAKEDATSU Hidetoshi , OZAKI Ryo , MORIYA Kei , ISHII Manabu , KINJO Tetsu , OZEKI Keiji , OOI Makoto , HAYASHI Ryohei , KAKIMOTO Kazuki , SHIMODATE Yuichi , KITAMURA Kazuya , YAMADA Akihiro , SONODA Akira , NISHIDA Yu , YOSHIOKA Kyouko , ASHIZUKA Shinya , TAKAHASHI Fumiaki , SHIMOKAWA Toshio , KOBAYASHI Taku , ANDOH Akira , HIBI Toshifumi

    … Cumulative surgery-free survival was 74.0% at 1 year, 54.4% at 5 years, and 44.3% at 10 years. … Receiver operating characteristic analysis revealed that an EBD interval of ≤ 446 days predicted subsequent surgery, and the proportion of smokers was significantly high in patients who required frequent dilatation. …

    Journal of Gastroenterology, 2020-01-27

    IR 

  • Effects of indium exposure on respiratory symptoms: a retrospective cohort study in Japanese workers using health checkup data

    Mitsuhashi Toshiharu

    … The Prentice-Williams-Peterson model was used for calculation, and a model that adjusted for coarse analysis and potential confounding factors was adopted. …

    PeerJ (8), e8413, 2020-01-15

    IR 

  • EBV status has prognostic implication among young patients with angioimmunoblastic T‐cell lymphoma

    坂田(柳元) 麻実子 , Ahmed E. Eladl , Kazuyuki Shimada , Yuka Suzuki , Taishi Takahara , Seiichi Kato , Kei Kohno , Ahmed Ali Elsayed , Chun‐Chieh Wu , Takashi Tokunaga , Tomohiro Kinoshita , Mamiko SAKATA-YANAGIMOTO , Shigeo Nakamura , Akira Satou

    … However, it remains controversial whether EBV status has an impact on the survival of patients with AITL. … Among the patients who received anthracycline‐based therapy, the EBER status did not affect the overall survival (OS) or progression‐free survival (PFS). … Furthermore, the multivariate analysis identified EBER‐negative status, thrombocytopenia, and elevated serum IgA level as significant adverse prognostic factors for PFS (P < …

    Cancer Medicine 9(2), 678-688, 2020-01

    IR 

  • Impact of age on clinicopathological features and survival of epithelial ovarian neoplasms in reproductive age

    Hanatani Maya , Yoshikawa Nobuhisa , Yoshida Kosuke , Tamauchi Satoshi , Ikeda Yoshiki , Nishino Kimihiro , Niimi Kaoru , Suzuki Shiro , Kawai Michiyasu , Kajiyama Hiroaki , Kikkawa Fumitaka

    … This study aimed to elucidate impact of age on the clinicopathologic characteristics and survival of epithelial ovarian neoplasms in the reproductive age. … Univariate and multivariate analyses were performed to evaluate overall survival and disease-free survival. … There was a significant difference in the overall survival (p = 0.0051) and the disease-free survival (p = 0.0039) between the two groups. …

    International Journal of Clinical Oncology 25(1), 187-194, 2020-01

    IR 

  • Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells

    大野 恵一 , 大竹 一男 , 渡辺 知恵 , 柴 祥子 , 関谷 剛 , 加園 恵三

    … Methods: PC3 cells were treated with various concentrations of EPA, and cell survival and the abilities of migration and invasion were evaluated. … The mechanism underlying the anti-cancer effects of EPA was investigated by human phosphokinase and human apoptosis antibody arrays, and confirmed by western blot analysis. … Results: EPA decreased the survival of PC3 cells in a dose-dependent manner within 3 h of application, with an effective concentration of 500 μmol/L. …

    Lipids in Health and Disease (19), 1-12, 2020-01

    IR 

  • Analysis of 33 cases of ABO incompatible kidney transplantation in Kochi Health Sciences Center  [in Japanese]

    澁谷 祐一 , 大石 一行 , 室川 剛廣 , 佐藤 琢爾 , 黒田 絵理 , 桂 佑貴 , 須井 健太 , 尾崎 和秀 , 坪井 一朗 , 小野 憲昭 , 堀見 忠司

    高知県医師会医学雑誌 = Journal of Kochi Medical Association 25(1), 219-225, 2020

  • Performance evaluation of standard error estimation with Greenwood formula in survival analysis : Pointwise interval estimation of the progression-free survival  [in Japanese]

    榎本 駿平 , 西川 哲夫 , 西川 正子

    武蔵野大学数理工学センター紀要 = The bulletin of Musashino University Musashino Center of Mathematical Engineering (5), 1-26, 2020

  • Variation in receipt of therapy and survival with provider volume for medical oncology in non-curative esophago-gastric cancer : a population-based analysis

    Hallet Julie , Davis Laura E. , Mahar Alyson L. , Liu Ying , Zuk Victoria , Gupta Vaibhav , Earle Craig C. , Coburn Natalie G.

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 23(2), 300-309, 2020

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