Search Results 1-20 of 5758

  • miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation

    Kozuka Takashi , Omori Yoshihiro , Watanabe Satoshi , Tarusawa Etsuko , Yamamoto Haruka , Chaya Taro , Furuhashi Mayu , Morita Makiko , Sato Tetsuya , Hirose Shinichi , Ohkawa Yasuyuki , Yoshimura Yumiko , Hikida Takatoshi , Furukawa Takahisa

    … Previous studies reported that miR-124 plays a role in CNS development, such as neuronal differentiation, maturation, and survival. … Based on the results of behavioral and electrophysiological analysis, we focused on genes involved in the dopaminergic system and identified a significant increase of Drd2 expression level in the miR-124-1⁺/⁻ PFC. …

    Scientific reports 9(1), 2019-03-05

    IR

  • Predictive preoperative factors of long-term survival rate after open surgery for abdominal aortic aneurysm

    Furuie Wakaba , Nagai Saya , Kudo Toshifumi , Inoue Yoshinori , Akaza Miho , Sasano Tetsuo , Sumi Yuki

    … Objective: We aimed to examine long-term survival rate andthe risk factors of poor prognosis in patients whounderwent open surgery (OS) for abdominal aorticaneurysm (AAA).Materials and Methods: We performed a retrospective analysis of thepatients who underwent elective OS for AAAbetween 2005 and 2011 at Tokyo Medical andDental University Hospital. …

    Journal of Medical and Dental Sciences = Journal of Medical and Dental Sciences 66(1), 13-22, 2019-03

    IR

  • Low-Dose vs. High-Dose Cisplatin: Lessons Learned From 59 Chemoradiotherapy Trials in Head and Neck Cancer

    Szturz Petr , Wouters Kristien , Kiyota Naomi , Tahara Makoto , Prabhash Kumar , Noronha Vanita , Adelstein David , Van Gestel Dirk , Vermorken Jan B.

    … We performed a composite meta-analysis of 59 prospective trials enrolling a total of 5,582 patients. … The primary endpoint was overall survival. … In the former two settings, both high-and low-dose regimens yielded similar survival outcomes, thus, the primary objective was not met. …

    Frontiers in Oncology (9), 86, 2019-02-21

    IR

  • Clinical impact of the loss of chromosome 7q on outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem cell transplantation

    Itonaga Hidehiro , Ishiyama Ken , Aoki Kazunari , Aoki Jun , Ishikawa Takayuki , Ohashi Kazuteru , Fukuda Takayuki , Ozawa Yukiyasu , Ota Shuichi , Uchida Naoyuki , Eto Tetsuya , Iwato Koji , Ohno Yuju , Takanashi Minoko , Ichinohe Tatsuo , Atsuta Yoshiko , Miyazaki Yasushi

    … The 3-year overall survival (OS) and cumulative incidence of relapse (CIR) were 50.4 and 19.4% for those with der(1;7), 36.2 and 38.4% for −7/del(7q),and 51.1 and 20.7% for NK, respectively. … In the multivariate analysis, the presence of −7/del(7q) correlated with a significantly shorter OS (HR [95% CI], 1.38 [1.00–1.89]; …

    Bone Marrow Transplantation, 2019-02-04

    IR DOI

  • A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching

    Otsuru Mitsunobu , Ota Yoshihide , Yanamoto Souichi , Okura Masaya , Umeda Masahiro , Kirita Tadaaki , Kurita Hiroshi , Ueda Michihiro , Komori Takahide , Yamakawa Nobuhiro , Kamata Takahiro , Hasegawa Takumi , Shibahara Takahiko , Ohiro Youichi , Yamashita Yoshihiro , Noguchi Kazuma , Noguchi Tadahide , Karakida Kazunari , Naito Hiroyuki , Aikawa Tomonao , Yamashita Tetsuro , Kabata Daijiro , Shintan Ayumi

    … The 5-year overall survival (OS) and 5-year disease-specific survival (DSS) were compared between the propensity score-matched END and observation (OBS) groups. …

    Annals of Surgical Oncology 26(2), 555-563, 2019-02

    IR

  • Factors predictive of long-term mortality in lupus nephritis: a multicenter retrospective study of a Japanese cohort

    Ichinose K , Kitamura M , Sato S , Fujikawa K , Horai Y , Matsuoka N , Tsuboi M , Nonaka F , Shimizu T , Fukui S , Umeda M , Koga T , Kawashiri S , Iwamoto N , Tamai M , Nakamura H , Origuchi T , Nishino T , Kawakami A

    … The patients' survival data were analyzed by the Kaplan–Meier method with a log-rank test.Results: The median follow-up duration after renal biopsy was 120 months (interquartile range: 60.3–191.8 months). … The 5-, 10-, 15- and 20-year survival rates of our cohort were 99.3, 94.6, 92.0 and 85.4%, respectively. …

    Lupus, 096120331982669, 2019-01-30

    IR DOI

  • Predicting the survival of patients with bone metastases treated with radiation therapy: a validation study of the Katagiri scoring system

    Kubota Hikaru , Soejima Toshinori , Sulaiman Nor Shazrina , Sekii Shuhei , Matsumoto Yoko , Ota Yosuke , Tsujino Kayoko , Fujita Ikuo , Fujimoto Takuya , Morishita Masayuki , Ikegaki Junichi , Matsumoto Koji , Sasaki Ryohei

    … It is reported that the Katagiri scoring system can be used to predict the survival of patients with bone metastases. … Age, sex, Karnofsky performance status (KPS), Eastern Cooperative Oncology Group performance status (ECOG PS), primary site (lesions and characteristics), visceral metastases, laboratory data, previous chemotherapy, and multiple bone metastases were analyzed for associations with overall survival (OS). …

    Radiation Oncology (14), 13, 2019-01-18

    IR

  • Introduction to survival analysis and competing risk  [in Japanese]

    森田 光治良

    Bone joint nerve : BJN 9(1), 37-43, 2019-01

  • Optimal time point of achieving MMR for prolonging PFS in patients with CML  [in Japanese]

    渡邉 純一 , 木崎 昌弘

    血液内科 = Hematology 78(1), 152-156, 2019-01

    Ichushi Web

  • Profile of the ORION (Osaka emergency information Research Intelligent Operation Network system) between 2015 and 2016 in Osaka, Japan: a population-based registry of emergency patients with both ambulance and in-hospital records

    Okamoto Jun , Katayama Yusuke , Kitamura Tetsuhisa , Sado Junya , Nakamura Ryuta , Kimura Nobuhiro , Misaki Hirotsugu , Yamao Shinpei , Nakao Shota , Nitta Masahiko , Iwami Taku , Fujimi Satoshi , Kuwagata Yasuyuki , Shimazu Takeshi , Matsuoka Tetsuya

    Analysis using the ORION database in the future could lead to improvements in the emergency transport system and patient outcomes. …

    Acute Medicine & Surgery 6(1), 12-24, 2019-01

    IR

  • Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer

    Iemoto Takao , Nishiumi Shin , Kobayashi Takashi , Fujigaki Seiji , Hamaguchi Tetsuya , Kato Ken , Shoji Hirokazu , Matsumura Yasuhiro , Honda Kazufumi , Yoshida Masaru

    … The survival times of patients with advanced colorectal cancer (CRC) have increased due to the introduction of chemotherapy involving irinotecan and cetuximab. … Serum metabolome analysis was performed using a multiplatform metabolomics system, and univariate Cox regression hazards analysis of the time to disease progression was conducted. …

    Oncology Letters 17(1), 831-842, 2019-01

    IR

  • Body composition assessment and sarcopenia in patients with gastric cancer : a systematic review and meta-analysis

    Kamarajah Sivesh K. , Bundred James , Tan Benjamin H. L.

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 22(1), 10-22, 2019

  • Impact of Lipoprotein (a) Levels on Long-Term Outcomes in Patients With Coronary Artery Disease and Left Ventricular Systolic Dysfunction

    Shitara Jun , Dohi Tomotaka , Okazaki Shinya , Miyauchi Katsumi , Daida Hiroyuki , Kasai Takatoshi , Konishi Hirokazu , Endo Hirohisa , Wada Hideki , Doi Shinichiro , Naito Ryo , Tsuboi Shuta , Ogita Manabu

    … Cumulative event-free survival was significantly worse for the group with high Lp(a) than for the group with low Lp(a) (P=0.005). … In the multivariable analysis, a high Lp(a) level was an independent predictor of the primary outcomes (hazard ratio, 1.54; …

    Circulation Journal, 2019

    J-STAGE

  • Prognostic Value of Left Atrial Size and Functional Indices Measured by 3-Dimensional Speckle-Tracking Analysis

    Tsujiuchi Miki , Nakadate Toshio , Kokaze Akatsuki , Suzuki Hiroshi , Yamauchi Takenori , Ebato Mio , Maezawa Hideyuki , Nogi Ayaka , Ikeda Naoko , Mizukami Takuya , Nagumo Sakura , Iso Yoshitaka

    … <p><b><i>Background: </i></b>The prognostic value of indices for left atrial volumes (LAV) and reservoir function measured by 3D speckle-tracking analysis (3DSTA) has not been determined. … Two cutoff values using normal±2SD (cutoff criterion 1) and receiver-operating characteristic analysis (cutoff criterion 2) were evaluated. …

    Circulation Journal 83(4), 801-808, 2019

    J-STAGE

  • NUPR1 acts as a pro-survival factor in human bone marrow-derived mesenchymal stem cells and is induced by the hypoxia mimetic reagent deferoxamine

    Matsunaga Kazuhito , Fujisawa Koichi , Takami Taro , Burganova Guzel , Sasai Nanami , Matsumoto Toshihiko , Yamamoto Naoki , Sakaida Isao

    … Here, the deferoxamine effects were investigated in mesenchymal stem cells to gain insights into the mechanisms regulating stem cell survival. … Microarray analysis revealed that deferoxamine enhanced the transcription of genes involved in glycolysis and the HIF1α pathway. … NUPR1, which is induced by stress and involved in autophagy-mediated survival, was upregulated by deferoxamine in a concentration-dependent manner. …

    Journal of Clinical Biochemistry and Nutrition, 2019

    J-STAGE

  • The clinical study of prognostic factors in patients with early tongue squamous cell carcinoma in our department  [in Japanese]

    Morikawa Takamichi , Kozakai Ayako , Bessho Hiroki , Otonari Mika , Imoto Kenichi , Wakoh Mamoru , Nomura Takeshi , Takano Nobuo , Shibahara Takahiko

    初期舌扁平上皮癌に対する予後因子について検討が行われている。深達度は後発頸部リンパ節転移に対する予後因子として重要である。しかし,この深達度は術後の病理標本の結果に基づいており,術前より予測することは困難である。また,画像所見と病理標本との比較についての報告は少ない。本研究では初期舌扁平上皮癌の予後因子,特に深達度に着目し,画像所見と予後との関連性について明らかにすることを目的とした。 2000年 …

    Journal of Japanese Society of Oral Oncology 31(1), 1-9, 2019

    J-STAGE

  • New clinical application of three-dimensional-printed polycaprolactone/β-tricalcium phosphate scaffold as an alternative to allograft bone for limb-sparing surgery in a dog with distal radial osteosarcoma

    CHOI Seongjae , OH Ye-In , PARK Keun-Ho , LEE Jeong-Seok , SHIM Jin-Hyung , KANG Byung-Jae

    … The outcomes evaluated included postoperative gait analysis, complications, local recurrence of tumor, metastasis, and survival time. … The survival time from diagnosis of OSA to death was 190 days. …

    Journal of Veterinary Medical Science 81(3), 434-439, 2019

    J-STAGE

  • A Decision Tree-Based Survival Analysis of Patients with a History of Inappropriate Implantable Cardioverter-Defibrillator Therapy

    Yamamoto Masaru , Kiyono Ken , Watanabe Eiichi , Ozaki Yukio , Okajima Katsunori , Shimane Akira , Ozawa Tomoya , Morishima Itsuro , Asai Toru , Takagi Masahiko , Kasai Atsunobu , Fujii Eitaro

    … <p>Implantable cardioverter-defibrillators (ICDs) improve survival in patients who are at risk of sudden death. … This study aimed to construct a risk stratification scheme by using decision tree analysis in patients who received inappropriate ICD therapy.</p><p>Mortality was calculated from a retrospective data analysis of a multicenter cohort involving 417 ICD recipients. …

    International Heart Journal 60(2), 318-326, 2019

    J-STAGE

  • Outcomes of Transcatheter Aortic Valve Implantation in Patients with Cirrhosis:A Case Series

    Higuchi Ryosuke , Takayama Morimasa , Isobe Mitsuaki , Tobaru Tetsuya , Hagiya Kenichi , Saji Mike , Mahara Keitaro , Takamisawa Itaru , Shimizu Jun , Iguchi Nobuo , Takanashi Shuichiro

    … Transcatheter aortic valve implantation (TAVI) has evolved as a less invasive therapy for aortic stenosis, whereas detailed case analysis of TAVI in cirrhotic patients is limited.</p><p>Among 444 consecutive patients who underwent TAVI in the Sakakibara Heart Institute between October 2013 and January 2018, we retrospectively reviewed 11 patients (2.5%) with cirrhosis. …

    International Heart Journal 60(2), 352-358, 2019

    J-STAGE

  • Intravenous Immunoglobulin Therapy for Acute Myocarditis in Children and Adults:A Meta-Analysis

    Huang Xin , Sun Yufei , Su Guanhua , Li Yu , Shuai Xinxin

    … The aim of this study was to conduct a meta-analysis to assess the efficacy of IVIG in children and adults with acute myocarditis.</p><p>We searched PubMed, Scopus, Embase, Medline, the Cochrane Library, Google Scholar, and the ClinicalTrials.gov website. … Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the outcomes.</p><p>Thirteen studies with 1534 cases were incorporated into our meta-analysis. …

    International Heart Journal 60(2), 359-365, 2019

    J-STAGE

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