Search Results 1-20 of 468

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Discontinuation of biosimilar infliximab in Japanese patients with rheumatoid arthritis achieving sustained clinical remission or low disease activity during the IFX-SIRIUS STUDY I (the IFX-SIRIUS STUDY II)

Shimizu Toshimasa , Kawashiri Shin-Ya , Sato Shuntaro , Morimoto Shimpei , Minoda Shuri , Kawazoe Yurika , Kuroda Shohei , Tashiro Shigeki , Sumiyoshi Remi , Hosogaya Naoki , Yamamoto Hiroshi , Kawakami Atsushi

… We are conducting the IFX-SIRIUS STUDY I that evaluates whether switching from originator infliximab (IFX) to its biosimilar, CT-P13, is not inferior in maintaining nonclinical relapse to continue treatment with originator IFX in patients with RA achieving clinical remission. … It is the next great issue whether disease activity can be maintained in good condition after discontinuation of CT-P13 because no evidence is available regarding the clinical value of discontinuing biosimilars in patients with RA. …

Medicine 99(32), e21480, 2020-08-07

IR
2

Switching from originator infliximab to biosimilar infliximab in Japanese patients with rheumatoid arthritis achieving clinical remission (the IFX-SIRIUS study I)

Kawashiri Shin-ya , Shimizu Toshimasa , Sato Shuntaro , Morimoto Shimpei , Kawazoe Yurika , Sumiyoshi Remi , Hosogaya Naoki , Fukushima Chizu , Yamamoto Hiroshi , Kawakami Atsushi

… We will evaluate whether switching from originator IFX to CT-P13 is not inferior for maintaining non-clinical relapse to continued treatment with originator IFX in RA patients achieving clinical remission. … We will evaluate disease activity by measuring clinical disease activity indices and by using musculoskeletal ultrasound (MSUS). …

Medicine 99(30), e21151, 2020-07-24

IR
3

Contactless mass transfer for intradroplet extraction

Asano Shusaku , Takahashi Yu , Maki Taisuke , Muranaka Yosuke , Cherkasov Nikolay , Mae Kazuhiro

… Separation of the alternating aqueous slugs at the outlet was performed by switching a couple of solenoid valves at branched outlets according to signals obtained by an optical sensor at the branch. … Position-specific mass transfer activity at the rear end of the aqueous slugs was found on the course of the experiment. …

Scientific Reports 20(7685), 2020-05-06

IR
4

Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity

Kimura Masahiro , Horie Takahiro , Baba Osamu , Ide Yuya , Tsuji Shuhei , Ruiz Rodriguez Randolph , Watanabe Toshimitsu , Yamasaki Tomohiro , Otani Chiharu , Xu Sijia , Miyasaka Yui , Nakashima Yasuhiro , Kimura Takeshi , Ono Koh

… Yes‐associated protein (YAP) and transcriptional enhancer activator domain (TEAD) transcriptional factors, the main transcriptional complex of the Hippo pathway, were recently identified as modulators of phenotypic switching of vascular smooth muscle cells (VSMCs). … Here, we identified Homeobox A4 (HOXA4) as a potent repressor of YAP/TEAD transcriptional activity using lentiviral shRNA screen. …

EMBO Reports 21(4), 2020-04-03

IR
5

The switching from intravenous to subcutaneous tocilizumab therapy relapsed disease activity in patients with mutilans type rheumatoid arthritis : report of two cases [in Japanese]

若林弘樹 , 西岡洋右 , 長谷川正裕 , 西岡久寿樹 , 湏藤啓広

整形外科 = Orthopedic surgery 71(1), 33-36, 2020-01

Ichushi Web
6

Analyzing Dynamic Chemical States of Palladium Supported on Graphene Oxide by X-ray Absorption Fine Structure under Oxidative and Reductive Environments

Kunisu Masahiro , Yahiro Jumpei , Morimoto Naoki , Nishina Yuta

… by switching atmosphere between H2 … The catalytic activity in dehydrogenation and hydrogenation reactions also depended on the oxygen content of GO. …

Chemistry Letters 49(11), 1337-1340, 2020

J-STAGE
7

Regression formula to predict the International Federation of Clinical Chemistry and Laboratory Medicine measure of alkaline phosphatase activity in canine blood based on the Japan Society of Clinical Chemistry reference method

HATA Akihisa , FUJITANI Noboru , TANAKA Chie , MATSUDA Noriko , TAKAISHI Michiko , SHIMOKAWA-MIYAMA Takako , HOSHI Fumio

… The Japan Society of Clinical Chemistry reference method (JSCC method) is used to measure alkaline phosphatase (ALP) activity only in Japan. … Other countries use the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) reference method to measure ALP activity. … Since April 2020, human medical institutions in Japan have been gradually switching to the IFCC method. …

Journal of Veterinary Medical Science 82(10), 1523-1528, 2020

J-STAGE
8

Shortening dose interval of subcutaneous tocilizumab in patients with rheumatoid arthritis [in Japanese]

Murata Miki , Yoshihara Ryosuke , Uefuji Atsuo , Nakagawa Natsuko , Tanaka Yasushi , Shiozawa Kazuko

… TCZ-SC投与間隔の短縮前と短縮後約８週時でのmatrix metalloprotease-3（MMP-3），C-reactive protein（CRP），赤血球沈降速度（ESR），患者による全般的評価（PtGA VAS），modified health assessment questionnaire（mHAQ），clinical disease activity index（CDAI）を後向きに検討した．結果：TCZ-SC短縮投与を受けた患者は11例．３例は十分な効果が得られたのちに，２週間隔投与にもどしても，その効果は維持されていた．短縮投与によりステ …

Clinical Rheumatology and Related Research 32(3), 194-200, 2020

J-STAGE
9

Clinical investigation of the use of bilastine (BilanoaⓇ) on chronic idiopathic urticaria that has inadequate response to other antihistamines [in Japanese]

Sasaki Go

… 当院を受診中の慢性特発性蕁麻疹患者で，既存の第2世代抗ヒスタミン薬効果不十分［重症度レベル3以上かつ蕁麻疹活動性スコア（Urticaria Activity Score：UAS）3以上］であった50例について，ビラスチン（ビラノアⓇ）への切り替えによる臨床的検討を行った．UASはビラスチン切り替え後2週間で有意な低下が認められ，その低下は8週後まで継続した．さらに前治療の薬剤が，ピペリジン/ピペラジン系およ …

Journal of the Japan Organization of Clinical Dermatologists 37(3), 417-423, 2020

J-STAGE Ichushi Web
10

Phenotypic Switching of Atherosclerotic Smooth Muscle Cells is Regulated by Activated PARP1-Dependent TET1 Expression

Zhang Chao , Chen Xin , Wang Ju-Kun , Li Yu , Cui Shi-Jun , Wang Zhonggao , Luo Tao

… Aim: During the development of atherosclerosis, the vascular smooth muscle cells (SMCs) undergo phenotypic switching from contractile phenotype to synthetic phenotype. … This study aimed at examining the role of DNA modification mediated by the oxidative stress dependent ten eleven translocation enzymes (TETs) expression at early stage of phenotypic switching. …

Journal of Atherosclerosis and Thrombosis, 2020

J-STAGE
11

Material Recycle Using Seaweed [in Japanese]

Okamoto Masaru

… As the exhaust gases from an ethanol ethanol-fueled carare more toxic than those from a conventionally fueled one, under low low-temperature operation, catalyst activity would need tobe assisted by electric discharge with a switching dev ice, namely MOS MOS-assisted gate triggered thyristor (MAGT), whichachieves both high speed and high capacity. …

Journal of Japan Society of Energy and Resources 41(5), 226-232, 2020

J-STAGE
12

Synthesis of Circularly Polarized Luminescence Dyes Based on Chiral Naphthalene Oligomers [in Japanese]

Takaishi Kazuto

… The bridged structure adjusts the angle between the vectors of the electric and magnetic transition dipole moments, which is essential for showing CPL activity. … This switching property originates from the inversion of excimer chirality caused by the presence or absence of intermolecular hydrogen bonds in the excited state. … The switching properties resulted from an inversion of the bipyridyl axis mediated by intramolecular hydrogen bonds. …

Journal of Synthetic Organic Chemistry, Japan 78(9), 846-855, 2020

J-STAGE
13

Semi-powered exoskeleton that regulates the muscular activity of jaw movement for oral functional rehabilitation/training

KAMEDA Takashi , SAKAMOTO Makoto , TERADA Kazuto

… Sequential device movement was controlled by two electronic circuits with two magnetic switching systems to match human jaw movement. … This exoskeleton realized a 25% increase of jaw-opening muscular activity for training, 15% saving of jaw-closing muscular activity for assistance, and 15% enhancement of saliva secretion, which could contribute to the prevention of oral frailty by maintenance and strengthening of oral function in the upcoming super-aging society. …

Dental Materials Journal, 2020

J-STAGE
14

Predicting self-condence in a web-based explanation activity with a pedagogical conversational agent: Investigation on individual characteristics and task work activity [in Japanese]

Hayashi Yugo

… Results show that an increase in the amount of actual task work for explanations and personal characteristics evaluated by AQ scores (such as social skills, attention switching, imagination) helped to predict higher self-confidence. …

The Transactions of Human Interface Society 22(3), 263-270, 2020

J-STAGE
15

A Series of Novel HDAC Inhibitors with Anthraquinone as a Cap Group

Zou Yefang , He Bin , Cao Zhuoxian , Wang Jie , Chen Xiaoxue , Chen Yan-qin , Li Yan , Liu Jingzi , Zhao Yonglong , Wang Aimin

… Although anthraquinone derivatives possess significant antitumor activity, most of them also displayed those side effects like cardiotoxicity, mainly owing to their inhibition of topoisomerase II of DNA repair mechanisms. … Our raised design strategy by switching therapeutic target from topoisomerase II to histone deacetylase (HDAC) has been applied to the design of anthraquinone derivatives in current study. …

Chemical and Pharmaceutical Bulletin 68(7), 613-617, 2020

J-STAGE
16

Predicting Uninterruptible Durations of Office Workers by Using Probabilistic Work Continuance Model

SHIRATORI Shota , FUJIMOTO Yuichiro , FUJITA Kinya

… An analysis of actual working data collected from 13 participants revealed the relationship between uninterruptible durations and four features, i.e. type of application software, rate of PC operation activity, activity ratio between keystrokes and mouse clicks, and switching frequency of application software. …

IEICE Transactions on Information and Systems E103.D(4), 838-849, 2020

J-STAGE
17

Switching between Three Types of Mesalazine Formulation and Sulfasalazine in Patients with Active Ulcerative Colitis Who Have Already Received High-Dose Treatment with These Agents

Yasutomi Eriko , Hiraoka Sakiko , Yamamoto Shumpei , Oka Shohei , Hirai Mami , Yamasaki Yasushi , Inokuchi Toshihiro , Kinugasa Hideaki , Takahara Masahiro , Harada Keita , Kato Jun , Okada Hiroyuki

… The efficacy of switching from one of the several mesalazine formulations to another is largely unknown. … This study assessed the efficacy of switching among three types of mesalazine formulation and SASP for UC therapy. … Methods: UC patients receiving high-dose mesalazine/SASP who switched to other formulations due to disease activity were considered eligible. … Efficacy was evaluated 2, 6, and 12 months after switching. …

Journal of Clinical Medicine 8(12), 2019-12-02

IR
18

3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival

Gülcüler Balta Gülce S. , Monzel Cornelia , Kleber Susanne , Beaudouin Joel , Balta Emre , Kaindl Thomas , Chen Si , Gao Liang , Thiemann Meinolf , Wirtz Christian R. , Samstag Yvonne , Tanaka Motomu , Martin-Villalba Ana

The death receptor CD95 is expressed in every cancer cell, thus providing a promising tool to target cancer. Activation of CD95 can, however, lead to apoptosis or proliferation. Yet the molecular dete …

Cell Reports 29(8), 2295-2306.e6, 2019-11-19

IR
19

Photo-manipulation of activity of enzymes bound to inorganic nanomaterials

Kamada Kai

… The present review introduces various enzymatic reaction systems employing an external light source (visible or UV light) to initiate enzymatic reaction and/or adjust its reaction rate, that is, photo-manipulation of enzymatic activity. … Hence, switching of enzymatic activity is achievable by turning on/off the light source. …

Journal of Solid State Chemistry (280), 120996, 2019-10-16

IR
20

A Low Capture Power Oriented X-filling Method Based on Iterative Partial MaxSAT Application [in Japanese]

三澤健一郎 , 平間勇貴 , 細川利典 , 山崎紘史 , 吉村正義 , 新井雅之

DAシンポジウム2019論文集 (2019), 190-195, 2019-08-21

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