Search Results 1-20 of 137

  • A case report of pulmonary amyloidosis recognized by detection of AA amyloid exclusively in alveolar macrophages

    Laohawetwanit Thiyaphat , Tanaka Kei , Zaizen Yoshiaki , Tabata Kazuhiro , Ando Kouji , Ishimoto Hiroshi , Mukae Hiroshi , Miyazaki Yasushi , Bychkov Andrey , Fukuoka Junya

    Amyloidosis is a rare condition in which tissue deposits of inert fibrillar protein result in organ damage and dysfunction. … Some of the most common forms are AL (amyloid light chain) protein and AA (amyloid-associated) type of amyloid fibril protein. … Pulmonary amyloidosis is relatively common but is usually asymptomatic. …

    Respiratory Medicine Case Reports (30), 101046, 2020-04-08

    IR 

  • A case of gastric AL amyloidosis with atypical endoscopic imaging findings  [in Japanese]

    Sumida Chihiro , Kako Makoto , Sasaki Akiko , Ichita Chikamasa , Kimura Karen , Nishino Takashi , Tazawa Tomohiko , Tasaki Junichi , Masuda Sakue , Koizumi Kazuya

    … Additional testing indicated a diagnosis of AL-type amyloidosis, revealing systemic amyloidosis in the lower gastrointestinal tract, kidneys, and bone marrow. … Typically, amyloid deposits are found in the gastrointestinal tract in 90% of systemic amyloidosis cases, with endoscopic findings providing variable results. …

    Progress of Digestive Endoscopy 96(1), 67-69, 2020

    J-STAGE 

  • Localized Lymph Node Light Chain Amyloidosis

    Yamamoto Akira , Fujii Nobuharu , Obika Mikako , Yamashita Taro , Otsuka Fumio

    … <p>The prognosis of systemic amyloid light chain (AL) amyloidosis is generally poor, hence requiring chemotherapy or hematopoietic stem cell transplantation, while the prognosis of localized AL amyloidosis without an abnormal monoclonal immunoglobulin light chain is good. …

    Internal Medicine, 2020

    J-STAGE 

  • A case of systemic AL amyloidosis diagnosed on muscle biopsy  [in Japanese]

    Yata Tomohiro , Miwa Takashi , Araki Katsuya , Kida Toru , Toyooka Keiko , Nishino Ichizo , Tatsumi Chikao

    … Amyloid myopathy indicated systemic AL amyloidosis; …

    Rinsho Shinkeigaku 60(1), 60-63, 2020

    J-STAGE  Ichushi Web 

  • High-dose melphalan and autologous stem cell transplantation for systemic light-chain amyloidosis  [in Japanese]

    塚田 信弘

    血液内科 = Hematology 78(3), 430-436, 2019-03

    Ichushi Web 

  • Current diagnosis and treatment of AL amyloidosis in Japan: a nationwide epidemiological survey  [in Japanese]

    SHIMAZAKI Chihiro

    … <p>Immunoglobulin light chain (AL) amyloidosis is a plasma cell disorder characterized by the deposition of insoluble fibrillary protein derived from misfolded immunoglobulin light chains in several organs, resulting in organ failure and death. … However, little information is available about the prevalence and demographic characteristics of AL amyloidosis and the treatment strategy for the condition in Japan. …

    Rinsho Ketsueki 60(8), 973-978, 2019

    J-STAGE  Ichushi Web 

  • A Case of Tracheobronchial Amyloidosis Complicated with Fibromyalgia, Systemic Scleroderma, and Sjögren Syndrome  [in Japanese]

    Tsukagoshi Yusuke , Hisada Takeshi , Sawada Yuri , Hachisu Yoshimasa , Kasahara Norimitsu , Tsurumaki Hiroaki , Yatomi Masakiyo , Sakurai Reiko , Sunaga Noriaki , Maeno Toshitaka

    … Primary tracheobronchial amyloidosis is a rare disease, but some cases coexisting with systemic disease have been reported. … A 58-year-old woman was referred to our hospital because of chronic cough that had occurred during the treatment of fibromyalgia, systemic scleroderma, and Sjögren syndrome. … Trans-bronchoscopic bronchial biopsy revealed AL amyloid deposit in the lesion, and thus we diagnosed tracheobronchial amyloidosis. …

    The Journal of the Japan Society for Respiratory Endoscopy 41(2), 160-163, 2019

    J-STAGE  Ichushi Web 

  • A DIAGNOSIS OF SYSTEMIC AMYLOIDOSIS IN PATIENT WHO PRESENTED WITH SUBMENTAL SWELLING CAUSED BY MACROGLOSSIA  [in Japanese]

    Takatsu Namiko , Uchio Norihiko , Kuroda Kento , Shigeta Yasushi

    …  Systemic amyloidosis is a rare disease involving multiple organs that is characterized by the deposition of amyloid protein throughout the body. … Herein, we report a case of systemic amyloidosis diagnosed in a patient who presented with the chief complaint of submental swelling caused by macroglossia. …

    JIBI INKOKA TEMBO 61(5), 262-267, 2018

    J-STAGE  Ichushi Web 

  • Diagnosis and management for amyloidosis : 2017 Clinical practice guidelines  [in Japanese]

    Masuda Teruaki , Ueda Mitsuharu , Ando Yukio

    … <p>Amyloidosis is a group of disorders characterized by extracellular accumulation of amyloid fibrils derived from various proteins. …

    Neurological Therapeutics 35(3), 174-178, 2018

    J-STAGE  Ichushi Web 

  • A case of asymptomatic localized gastric amyloidosis  [in Japanese]

    Sano Masaya , Suzuki Takayoshi , Matsushima Masashi , Mine Tetsuya , Nakahara Fumio , Monma Makiko , Mizukami Hajime , Nakamura Jun , Fujisawa Mia , Uchida Tetsuhumi , Koike Jun , Kajiwara Hiroshi

    … A discolored and slightly depressed lesion on the front wall of the gastric antrum was observed by upper GI endoscopy and diagnosed as amyloidosis of AL type by histological examinations of the biopsy samples. … Most cases of AL amyloidosis are secondary and systemic and systemic examinations were performed. …

    Progress of Digestive Endoscopy 93(1), 93-95, 2018

    J-STAGE  Ichushi Web 

  • High-dose melphalan and autologous stem cell transplantation for systemic light-chain amyloidosis  [in Japanese]

    Tsukada Nobuhiro

    … <p> High-dose melphalan and autologous stem cell transplantation (HDM/ASCT) is an effective treatment option for patients with AL amyloidosis. …

    Journal of Hematopoietic Cell Transplantation 7(3), 65-72, 2018

    J-STAGE  Ichushi Web 

  • A Case of AL Amyloidosis Associated with Multiple Myeloma that Presented with Swelling of the Submandibular Region  [in Japanese]

    Kitajima Tatsuya , Shimane Toshikazu , Egawa Shunya , Asano Masayo , Mizuyoshi Tomomi , Ishibashi Atsushi , Ikenoya Yoichi , Kushihashi Yukiomi , Ikeda Kenichiro , Kobayashi Hitome

    Amyloidosis has been categorized mainly into systemic amyloidosis, in which amyloid deposition occurs in systemic organs, and localized amyloidosis, in which the deposition is limited to organ(s). … Amyloidosis is generally diagnosed on the basis of symptoms arising from amyloid deposition in the kidney, heart or gastrointestinal tract. …

    Practica Oto-Rhino-Laryngologica 111(6), 401-408, 2018

    J-STAGE  Ichushi Web 

  • Elevation of Plasmin-α2-plasmin Inhibitor Complex Predicts the Diagnosis of Systemic AL Amyloidosis in Patients with Monoclonal Protein

    Ishiguro Kazuya , Hayashi Toshiaki , Yokoyama Yoshihiro , Aoki Yuka , Onodera Kei , Ikeda Hiroshi , Ishida Tadao , Nakase Hiroshi

    … <p><b>Objective </b>The complication of systemic immunoglobulin light chain (AL) amyloidosis in patients with monoclonal immunoglobulin affects the prognosis, but amyloid deposition in tissues is sometimes difficult to detect due to bleeding tendencies and preferential distributions. … However, fibrinolysis is known to be exacerbated in patients with systemic AL amyloidosis specifically. …

    Internal Medicine 57(6), 783-788, 2018

    J-STAGE  Ichushi Web 

  • Nationwide Survey of 741 Patients with Systemic Amyloid Light-chain Amyloidosis in Japan

    Shimazaki Chihiro , Ando Yukio , Hata Hiroyuki , Iida Sinsuke , Ueda Mitsuharu , Katoh Nagaaki , Sekijima Yoshiki , Ikeda Shuichi , Yazaki Masahide , Fukushima Wakaba

    … <p><b>Objective </b>To retrospectively investigate the clinical manifestations of systemic amyloid light-chain (AL) amyloidosis in Japanese patients and the treatment strategy for the condition. … </p><p><b>Methods </b>We conducted a survey of Japanese AL amyloidosis patients, who were treated between January 1, 2012, and December 31, 2014. …

    Internal Medicine 57(2), 181-187, 2018

    J-STAGE  Ichushi Web 

  • A Novel Method of DAPI Staining for Differential Diagnosis of Renal Amyloidosis

    Matsuura Motokazu , Doi Toshio , Abe Hideharu , Tominaga Tatsuya , Sakurai Akiko , Murakami Taichi , Kishi Seiji , Bando Yoshimi , Minakuchi Jun , Nagai Kojiro

    … <p>Amyloidosis is often overlooked because its clinical manifestations can mimic those of more-common diseases. … Amyloidosis is a disorder caused by deposition of insoluble abnormal amyloid. … Classification of amyloidosis is based on the precursor protein that forms the amyloid fibrils and the distribution of amyloid deposits as either systemic or localized. …

    The Journal of Medical Investigation 64(3.4), 217-221, 2017

    IR  J-STAGE  Ichushi Web 

  • A case of amyloid myopathy diagnosed during the treatment of myopathy associated with anti-signal recognition particle antibodies  [in Japanese]

    Kawakami Nobuko , Katsuyama Yusuke , Hagiwara Yuka , Yoshida Hidefumi , Kim Kang , Harada Kiyoshi

    … The patient was diagnosed with amyloid myopathy, and therapy for systemic amyloid light chain amyloidosis caused muscle weakness to diminish. … Amyloidosis is believed to be the primary pathology in this case based on the patient's response to treatment reaction, but the significance of a case involving both amyloid myopathy and necrotizing myopathy warranted examination.</p> …

    Rinsho Shinkeigaku 57(4), 168-173, 2017

    J-STAGE  Ichushi Web 

  • Systemic AL Amyloidosis with Colonic Submucosal Hematoma

    Sasaki Sho , Nishikawa Jun , Hashimoto Shinichi , Sakaida Isao

    Internal Medicine 56(6), 741-742, 2017

    J-STAGE  Ichushi Web 

  • Clinical Presentation of Tubulointerstitial Nephritis Caused by Amyloid Light-chain Amyloidosis in a Patient with Sjögren's Syndrome

    Inoue Reiko , Uchida Shunya , Fujigaki Yoshihide , Kobayashi Kana , Tamura Yoshifuru , Ota Tatsuru , Shibata Shigeru , Ishida Tsuyoshi , Kondo Fukuo , Yamaguchi Yutaka

    … Unexpectedly, renal pathology revealed amyloid light-chain (AL) lambda-type depositions predominantly in the vasculatures with severe tubulointerstitial damage. … Given the involvement in other organs, systemic AL amyloidosis was diagnosed. … It should be remembered that renal amyloidosis occurs as a clinical presentation of interstitial nephritis. …

    Internal Medicine 56(4), 419-423, 2017

    J-STAGE 

  • A Case of Primary Tracheobronchial Amyloidosis with Preceding Hoarseness  [in Japanese]

    Igarashi Shuta , Nishikawa Yoshimi , Emura Masahito , Nakamura Takaya , Hayashi Takanori , Kobayashi Yusuke , Nomura Natsuko , Ota Takahiro , Yoshioka Hidetoshi , Niwamoto Takafumi

    … Primary tracheobronchial amyloidosis is a rare disease. … She had no signs of systemic amyloidosis and no cause of secondary amyloidosis. … We therefore diagnosed her illness as primary tracheobronchial amyloidosis. … In a recent study, 34-35% of patients with tracheobronchial amyloidosis had complained of hoarseness. …

    The Journal of the Japan Society for Respiratory Endoscopy 38(6), 500-504, 2016

    J-STAGE 

  • Liver Transplantation Is a Potential Treatment Option for Systemic Light Chain Amyloidosis Patients with Dominant Hepatic Involvement: A Case Report and Analytical Review of the Literature

    Ueno Akihiro , Katoh Nagaaki , Aramaki Osamu , Makuuchi Masatoshi , Ikeda Shu-ichi

    Systemic light chain (AL) amyloidosis is caused by abnormal plasma cell clones producing amyloidogenic light chains. … We herein report a 58-year-old man with advanced hepatic AL amyloidosis who was successfully treated using this strategy. …

    Internal Medicine 55(12), 1585-1590, 2016

    J-STAGE 

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