Search Results 1-20 of 2459

  • Molecular mechanisms of pigmented lesion induced by photoaging and therapeutic approach for it  [in Japanese]

    船坂 陽子

    Cosmetic stage 15(1), 16-24, 2020-10

  • A new therapeutic approach targeting cell cycle-related molecules against high grade B-cell lymphoma  [in Japanese]

    田中 佑加 , 百瀬 修二 , 田丸 淳一 , 木崎 昌弘

    血液内科 = Hematology 81(3), 364-371, 2020-09

  • Case Report : Laparoscopic Excisional Surgery for Growing Teratoma Syndrome Presenting 19 Years after Initial Treatment : A Case Report

    Tagui Chiho , Ishida Hiroaki , Takashima Akiko , Manrai Megumi , Kinoshita Toshihiko

    … Laparoscopic surgery is an effective alternative diagnostic and therapeutic approach in cases suggestive of GTS. …

    Toho journal of medicine 6(3), 132-135, 2020-09

    IR  DOI 

  • A possible beneficial effect of Bacteroides on faecal lipopolysaccharide activity and cardiovascular diseases

    Yoshida Naofumi , Yamashita Tomoya , Kishino Shigenobu , Watanabe Hikaru , Sasaki Kengo , Sasaki Daisuke , Tabata Tokiko , Sugiyama Yuta , Kitamura Nahoko , Saito Yoshihiro , Emoto Takuo , Hayashi Tomohiro , Takahashi Tomoya , Shinohara Masakazu , Osawa Ro , Kondo Akihiko , Yamada Takuji , Ogawa Jun , Hirata Ken-ichi

    … therefore, increasing Bacteroides abundance might serve as a novel therapeutic approach to prevent CVD via reducing faecal LPS levels and suppressing immune responses. …

    Scientific Reports 10(1), 13009, 2020-08-03

    IR 

  • Progress in therapeutic approach to Spinal Muscular Atrophy  [in Japanese]

    齊藤 利雄 , 西尾 久英

    難病と在宅ケア 26(5), 29-33, 2020-08

    Ichushi Web 

  • Sodium-Glucose Cotransporter-2 inhibitors are potential therapeutic agents for treatment of non-diabetic heart failure patients

    Nakagawa Yasuaki , Kuwahara Koichiro

    … It is expected, therefore, that SGLT2 inhibitors will be useful therapeutic agents for the treatment of heart failure. … The results of that study highlight the significance of SGLT2 inhibition as a novel therapeutic approach to treating HFrEF, irrespective of the presence or absence of diabetes. …

    Journal of Cardiology 76(2), 123-131, 2020-08

    IR 

  • Essential therapeutic approach in diabetic patients with CKD  [in Japanese]

    金﨑 啓造

    Heart view 24(7), 645-651, 2020-07

    Ichushi Web 

  • Quadrigeminal arachnoid cyst with perinatal encephalocele

    鶴淵 隆夫 , 石川 栄一 , Kazuki Akutagawa , Goichiro Tamura , Takao TSURUBUCHI , Eiichi ISHIKAWA , Akira Matsumura , Takayuki Inagaki

    … and while some treatments have been developed in recent years, no definite therapeutic approach for QAC has been established. … We performed neuroendoscopic cyst fenestration with an occipital bone approach. …

    Child's Nervous System 36(7), 1393-1397, 2020-07

    IR 

  • Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5

    Yamamura Tomohiko , Horinouchi Tomoko , Adachi Tomomi , Terakawa Maki , Takaoka Yutaka , Omachi Kohei , Takasato Minoru , Takaishi Kiyosumi , Shoji Takao , Onishi Yoshiyuki , Kanazawa Yoshito , Koizumi Makoto , Tomono Yasuko , Sugano Aki , Shono Akemi , Minamikawa Shogo , Nagano China , Sakakibara Nana , Ishiko Shinya , Aoto Yuya , Kamura Misato , Harita Yutaka , Miura Kenichiro , Kanda Shoichiro , Morisada Naoya , Rossanti Rini , Ye Ming Juan , Nozu Yoshimi , Matsuo Masafumi , Kai Hirofumi , Iijima Kazumoto , Nozu Kandai

    … This data suggests that exon skipping may represent a promising therapeutic approach for treating severe male XLAS cases. …

    Nature Communications 11(1), 2777, 2020-06-02

    IR 

  • Stem Cell Therapy in Heart Disease: Limitations and Future Possibilities

    Sano Toshikazu , Ishigami Shuta , Ito Tatsuo , Sano Shunji

    … Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. … Although a large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach, the results obtained from these clinical studies are inconsistent, and stem cell-based improvements of heart performance and cardiac remodeling were found to be quite limited. …

    Acta Medica Okayama 74(3), 185-190, 2020-06

    IR  DOI 

  • Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells

    Nawara Hend M. , Afify Said M. , Hassan Ghmkin , Zahra Maram H. , Atallah Marwa N. , Mansour Hager , Abu Quora Hagar A. , Alam Md Jahangir , Osman Amira , Kakuta Hiroki , Hamada Hiroki , Seno Akimasa , Seno Masaharu

    … Combination therapy, which is a treatment modality combining two or more therapeutic agents, is considered a cornerstone of cancer therapy. … These results suggest the combination therapy of paclitaxel and sorafenib in low doses should be an attractive approach to target cancer stem cells with fewer side effects. …

    Cancers 12(6), 1360, 2020-05-26

    IR 

  • Totally Thoracoscopic Resection of Schwannoma Located in Retroperitoneum and Posterior Mediastinum : Case Report  [in Japanese]

    神保 充孝 , 郷良 秀典 , 高橋 雅弥 , 大塚 遼 , 上杉 尚正 , 小林 俊郎 , 斉藤 聡 , 高橋 剛

    … We here report a case of retroperitoneal and posterior mediastinal schwannoma resected via a thoracoscopic approach.A man in his 40s was referred to our hospital because a well-circumscribed 51×47 mm diameter mass had been identified in the retroperitoneal area between the abdominal aorta and left kidney by computed tomography(CT).The mass also extended into the posterior mediastinum. … The suspected diagnosis being neurogenic tumor, surgery was performed for diagnostic and therapeutic purposes. …

    山口医学 = Yamaguchi medical journal 69(2), 93-97, 2020-05

    IR  Ichushi Web 

  • Current issues and perspectives in PD-1 blockade cancer immunotherapy

    Chamoto Kenji , Hatae Ryusuke , Honjo Tasuku

    … These drawbacks highlight the need for further investigation of the mechanisms underlying the therapeutic effects, as well as the need to develop novel biomarkers to predict the lack of treatment response and to monitor potential adverse events. … Combination therapy is a promising approach to improve the efficacy of PD-1 blockade therapy. …

    International Journal of Clinical Oncology (25), 790-800, 2020-05

    IR 

  • Influence of human adipose stem cells on prostate cancer cell growth

    Yamamoto Tokunori , Gotoh Momokazu , Koide Naoshi , Funahashi Yasuhito , Shimizu Shinobu , Takei Yoshifumi

    … Since the candidates for this treatment included prostate cancer patients after radical prostatectomy, we investigated the effects of ASCs on prostate cancer cell proliferation in vitro and in vivo to confirm the feasibility of our therapeutic approach. …

    Nagoya Journal of Medical Science 82(2), 217-224, 2020-05

    IR  DOI 

  • Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model

    Kashima Soki , Maeda Takuya , Masuda Kyoko , Nagano Seiji , Inoue Takamitsu , Takeda Masashi , Kono Yuka , Kobayashi Takashi , Saito Shigeyoshi , Higuchi Takahiro , Ichise Hiroshi , Kobayashi Yuka , Iwaisako Keiko , Terada Koji , Agata Yasutoshi , Numakura Kazuyuki , Saito Mitsuru , Narita Shintaro , Yasukawa Masaki , Ogawa Osamu , Habuchi Tomonori , Kawamoto Hiroshi

    … To address these issues, we developed a strategy in which cytotoxic T lymphocytes (CTLs) are regenerated from iPSCs that were originally derived from T cells and succeeded in regenerating CTLs specific for the WT1 antigen, which exhibited therapeutic efficacy in a xenograft model of leukemia. … The regenerated WT1-specific CTLs had a strong therapeutic effect in orthotopic xenograft model using a renal cell carcinoma (RCC) cell line. …

    iScience 23(4), 100998, 2020-04-24

    IR 

  • Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model

    Kashima Soki , Maeda Takuya , Masuda Kyoko , Nagano Seiji , Inoue Takamitsu , Takeda Masashi , Kono Yuka , Kobayashi Takashi , Saito Shigeyoshi , Higuchi Takahiro , Ichise Hiroshi , Kobayashi Yuka , Iwaisako Keiko , Terada Koji , Agata Yasutoshi , Numakura Kazuyuki , Saito Mitsuru , Narita Shintaro , Yasukawa Masaki , Ogawa Osamu , Habuchi Tomonori , Kawamoto Hiroshi

    … To address these issues, we developed a strategy in which cytotoxic T lymphocytes (CTLs) are regenerated from iPSCs that were originally derived from Tcells and succeeded in regenerating CTLs specific for the WT1 antigen, which exhibited therapeutic efficacy in a xenograft model of leukemia. … The regenerated WT1-specific CTLs had a strong therapeutic effect in orthotopic xenograft model using a renal cell carcinoma (RCC) cell line. …

    iScience 23(4), 2020-04-24

    IR 

  • Gene Therapy Approach for Intervertebral Disc Degeneration: An Update

    Takeoka Yoshiki , Yurube Takashi , Nishida Kotaro

    … Gene therapy approach involves gene transfer into cells, affects RNA and protein synthesis of the encoded genes in the recipient cells, and facilitates biological treatment. … Relatively long-exerting therapeutic effects by gene therapy are potentially advantageous to treat slow progressive degenerative disc disease. …

    Neurospine 17(1), 3-14, 2020-03-31

    IR 

  • Diagnosis and therapeutic approach for acquired hemophilia  [in Japanese]

    大森 司

    血液内科 = Hematology 80(3), 461-467, 2020-03

    Ichushi Web 

  • Multiple Virtual Screening Strategies for the Discovery of Novel Compounds Active Against Dengue Virus: A Hit Identification Study

    重田 育照 , Kowit Hengphasatporn , Arthur Garon , Peter Wolschann , Thierry Langer , Yasuteru SHIGETA , Thao N.T. Huynh , Warinthorn Chavasiri , Thanaphon Saelee , Siwaporn Boonyasuppayakorn , Thanyada Rungrotmongkol

    … No effective prevention or therapeutic agents to cure this disease are available up to now. … In the present study, pharmacophore models were generated using the common hits approach (CHA), starting from trajectories obtained from molecular dynamics (MD) simulations of the E protein complexed with the active inhibitor, flavanone (FN5Y). …

    Scientia pharmaceutica 88(1), 2, 2020-03

    IR 

  • The counselor-client relationship in psychotherapy : A qualitative analysis of counselors' and clients' experience  [in Japanese]

    金沢 吉展 , 上野 まどか , 横澤 直文 , 中山 愛美

    … Counselors should be accepting and empathic, present a clear therapeutic framework, as well as accurately assess and respond to clients' needs.【原著/Original Articles】 …

    明治学院大学心理学紀要 = Bulletin of psychology (30), 13-26, 2020-03

    IR  Ichushi Web 

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