Search Results 1-20 of 1118

  • Effects of surface roughness of ceria-stabilized zirconia/alumina nanocomposite on the morphology and function of human gingival fibroblasts

    AKIYAMA Yuri , IWASA Fuminori , HOTTA Yasuhiro , MATSUMOTO Takashi , OSHIMA Yoko , BABA Kazuyoshi

    … Biological parameters including cell adhesion, proliferation and morphology, collagen deposition, and inflammatory cytokine expression were evaluated for each disk. … Cell adhesion and proliferation and collagen deposition were significantly increased on Ce-TZP/Al<sub>2</sub>O<sub>3 </sub>Ra0.02 disk compared with the others, with no significant differences in cytokine expression among all the disks. …

    Dental Materials Journal 40(2), 472-480, 2021

    J-STAGE 

  • Pleiotropic effects of erythropoietin on renal and aortic injury in sucrose-induced insulin resistant rats  [in Japanese]

    Toba Hiroe , Kaino Yota , Zaizen Satoka , Nishikawa Momoyo , Yamaoka Akihiro , Kobara Miyuki , Nakata Tetsuo

    … Impairment of insulin signaling occurs not only in hepatic and muscle cells but also in vascular and renal cells, which are suggested to contribute to tissue injury. … Erythropoietin reduced fibrotic collagen deposition in renal tubulointerstitial area and macrophage infiltration in aortic adventitia. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P2-14, 2021

    J-STAGE 

  • Development of liver organoid culture from NASH mouse model and the application to drug discovery  [in Japanese]

    Usui Tatsuya

    … The three-dimensional organoid culture method has been attracting attention because it enables us to culture epithelial cells and epithelial stem cells in a three-dimensional manner for a long period of time by culturing them in a special culture medium containing factors that enhance the stem cell nature and maintain the original characteristics of the tissue, such as heterogeneity and polarity. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-S21-2, 2021

    J-STAGE 

  • Differentiation-inducing factor-1 accelerates adipogenic differentiation and suppresses the osteogenic differentiation of bone marrow-derived mesenchymal stem cells  [in Japanese]

    Ishikane Shin , Ikushima Eigo , Takiguchi Tomohiro , Matsunaga Hiroaki , Kishigami Takehiro , Toyohira Yumiko , Takahashi Fumi

    … <p>Mesenchymal stem cells (MSCs) are an attractive cell source for tissue regeneration and repair. … In contrast, DIF-1 significantly attenuated the effects of osteogenic differentiation stimuli, which were evaluated as alizarin red-S positive calcium deposition, and the expression of osteoblast differentiation markers. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-O-G3-2, 2021

    J-STAGE 

  • MiR-133a-3p inhibits scar formation in scalded mice and suppresses the proliferation and migration of scar derived-fibroblasts by targeting CTGF

    HIRMAN Abdul Razaq , DU Lili , CHENG Shaohang , ZHENG Heng , DUO Linna , ZHAI Qianyu , XU Jing

    … It was found that miR-133a-3p was dramatically downregulated in scar tissue of scalded mice. … Histological staining showed that upregulation of miR-133a-3p attenuated the excessive deposition of collagen in scar tissue of scalded mice.<i> … The expression of connective tissue growth factor (CTGF), a critical mediator in cell proliferation, migration and extracellular matrix (ECM) synthesis, was also downregulated by the upregulation of miR-133a-3p. …

    Experimental Animals, 2021

    J-STAGE 

  • Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles

    NAKAMURA Megumi , AOYAMA Naoki , YAMAGUCHI Satoshi , SASANO Yasuyuki

    … We examined mineral deposition <i>via</i> …

    Biomedical Research 42(1), 13-21, 2021

    J-STAGE 

  • Treatment of Hepatitis C Virus Infection with Direct-acting Antiviral Agents Elevates the Serum Small-dense Low-density Lipoprotein Cholesterol Level

    Hino Naoyuki , Miyaaki Hisamitsu , Ichikawa Tatsuki , Nakao Kazuhiko , Sasaki Ryu , Takahashi Youichi , Koike Makiko , Fukushima Masanori , Haraguchi Masafumi , Honda Takuya , Miuma Satoshi , Ozawa Eisuke

    … The Kaplan-Meier curve indicated that patients with high values of LDL, albumin, muscle attenuation and visceral to subcutaneous adipose tissue area ratio were at increased risk for elevation of sdLDL over 35 mg/dL (log-rank test: p<0.001; … </p><p><b>Conclusion </b>SdLDL increased continuously after DAA treatment, and high LDL levels and low intramuscular fat deposition before treatment contributed to elevated sdLDL levels after treatment. …

    Internal Medicine 60(2), 191-199, 2021

    J-STAGE 

  • Ultrasound and Clinicopathological Study of Steatohepatitic Hepatocellular Carcinoma  [in Japanese]

    YAMAGUCHI Kazuma , SAITO Satoshi , DENPO Hideyuki , KUBOTA Koichi , FUJIYAMA Shunichiro , KOBAYASHI Masahiro , HASHIMOTO Masaji , KINOWAKI Keiichi

    <p><b>目的</b>:2019年版WHO分類で新たに肝細胞癌の亜型とされた,Steatohepatitic hepatocellular carcinoma (SH-HCC)に関して超音波所見を中心に臨床病理学的な検討を行いBモード像の特徴を明らかにする.<b>対象と方法</b>:対象は2015‐2019年に治癒切除された肝細胞癌47 …

    Choonpa Igaku 48(1), 45-55, 2021

    J-STAGE 

  • The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions

    Kanda Akira , Asako Mikiya , Iwai Hiroshi , Yun Yasutaka , Bui Dan Van , Nguyen Linh Manh , Kobayashi Yoshiki , Suzuki Kensuke , Mitani Akitoshi , Sawada Shunsuke , Hamada Satoko

    … for example, eosinophils contribute to adipose tissue metabolism and metabolic health through alternatively activated macrophages and the maintenance of plasma cells in intestinal tissue and bone marrow. …

    Allergology International 70(1), 9-18, 2021

    J-STAGE 

  • Mechanisms of Vascular Calcification  [in Japanese]

    塩井 淳

    血管石灰化は動脈壁にリン酸カルシムが沈着する異所性石灰化であり, 心血管イベントの発症と関連する重要な病態と考えられている. 血管石灰化はその発症部位により内膜石灰化と中膜石灰化の二つに分類される. 内膜石灰化はアテローム性動脈硬化により形成される内膜プラークに見られる石灰化で, 内腔狭窄やプラークの破綻などにより動脈硬化性疾患(心筋梗塞, 脳梗塞, 閉塞性動脈硬化症)の発症に関与する. 一方, …

    大阪市医学会雑誌 (69), 15-22, 2020-12-25

    IR  Ichushi Web 

  • Matrix metallopeptidase expression and modulation by transforming growth factor-β1 in equine endometrosis

    Mioduchowska Anna Szóstek , Słowińska Mariola , Pacewicz Joanna , Skarzynski Dariusz J. , Okuda Kiyoshi

    … Its characteristic feature is excessive deposition of extracellular matrix (ECM) components around the endometrial glands and stroma. … In other species, one of the important regulators of MMPs and tissue inhibitors of MMPs (TIMPs) is transforming growth factor (TGF)-β1. …

    Scientific Reports 10(1), 1119, 2020-12

    IR 

  • Chondrogenic differentiation of mesenchymal stem/stromal cells on 3D porous poly (ε-caprolactone) scaffolds : Effects of material alkaline treatment and chondroitin sulfate supplementation

    Moura Carla Sofia , Silva Joao Carlos , Faria Sofia , Fernandes Paulo Rui , da Silva Claudia Lobato , Cabral Joaquim Manuel Sampaio , Linhardt Robert , Bartolo Paulo Jorge , Ferreira Frederico Castelo

    Journal of bioscience and bioengineering 129(6), 756-764, 2020-06

    DOI 

  • Fabrication and Characterization of Poly Lactic Acid Scaffolds by Fused Deposition Modeling for Bone Tissue Engineering

    Khodaei Mohammad , Amini Kamran , Valanezhad Alireza

    … Three-dimensional porous poly-lactic acid (PLA) scaffold was fabricated using fused deposition modeling (FDM) method including 30%, 50% and 70% nominal porosity. … The mechanical properties of the poly-lactic acid scaffolds printed using fused deposition modeling, can be adapted to the surrounding tissue, by porosity change. …

    Journal of Wuhan University of Technology-Mater. Sci. Ed. 35(1), 248-251, 2020-04-10

    IR 

  • A case report of pulmonary amyloidosis recognized by detection of AA amyloid exclusively in alveolar macrophages

    Laohawetwanit Thiyaphat , Tanaka Kei , Zaizen Yoshiaki , Tabata Kazuhiro , Ando Kouji , Ishimoto Hiroshi , Mukae Hiroshi , Miyazaki Yasushi , Bychkov Andrey , Fukuoka Junya

    … Amyloidosis is a rare condition in which tissue deposits of inert fibrillar protein result in organ damage and dysfunction. … Histologically, there was no amyloid deposition in the lung parenchyma;however, some histiocytes showed eosinophilic granular contents which prompted us to perform additional staining. … Recognition of amyloid deposition in alveolar macrophages may be an important clue to diagnose pulmonary amyloidosis. …

    Respiratory Medicine Case Reports (30), 101046, 2020-04-08

    IR 

  • A case report of pulmonary amyloidosis recognized by detection of AA amyloid exclusively in alveolar macrophages

    Laohawetwanit Thiyaphat , Tanaka Kei , Zaizen Yoshiaki , Tabata Kazuhiro , Ando Kouji , Ishimoto Hiroshi , Mukae Hiroshi , Miyazaki Yasushi , Bychkov Andrey , Fukuoka Junya

    … Amyloidosis is a rare condition in which tissue deposits of inert fibrillar protein result in organ damage and dysfunction. … Histologically, there was no amyloid deposition in the lung parenchyma;however, some histiocytes showed eosinophilic granular contents which prompted us to perform additional staining. … Recognition of amyloid deposition in alveolar macrophages may be an important clue to diagnose pulmonary amyloidosis. …

    Respiratory Medicine Case Reports (30), 101046, 2020-04-08

    IR 

  • Matching times: Trying to improve the correlation between heavy metal levels in mosses and bulk deposition

    M.T. Boquete , A. Ares , J.A. Fernández , J.R. Aboal

    … The relationship between the concentrations of metals in moss tissues and atmospheric deposition is highly complex, resulting in a general lack of correlations between these two matrices. … Here, we tried to improve the significance of the moss-bulk deposition (BD) relationship by eliminating the mismatch between the time that the moss tissue selected for analysis is exposed to atmospheric deposition, and the time during which BD is collected. …

    Science of The Total Environment (715), 136955, 2020-01-27

    IR 

  • Three cases of benign symmetric lipomatosis of the neck  [in Japanese]

    Sunagane Miki , Yamasaki Kazuki , Koshizuka Keiichi , Ohki Yuji , Iinuma Tomohisa , Kinoshita Takashi , Suzuki Takeshi , Yonekura Shuji , Hanazawa Toyoyuki

    良性対称性脂肪腫症(Madelung病)は頸部や躯幹,四肢などに対称性,多発性に脂肪が蓄積する疾患である。Madelung病の3例を経験したので考察を加えて報告する。症例1は76歳男性で,嗄声や嚥下障害,喉頭周囲の脂肪沈着を認めた。手術後の嚥下機能の悪化を懸念して経過観察の方針とした。症例2は61歳男性で,咽頭後間隙に脂肪組織を認め腫瘍摘出術を行った。症例3は72歳男性で,咽頭後および傍咽頭間隙に …

    JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY 30(3), 401-408, 2020

    J-STAGE 

  • Systemic Administration of Insulin in Subcutis of Rats for <i>in Vitro</i> Calcified Nodule Deposition by Bone Marrow Cells

    YOSHIKAWA Masataka , MIYAMOTO Ayano , NAKAMA Hitomi , MAEDA Hiroshi

    … The solution (0.5 U) was injected into the dorsal subcutaneous tissue of rats in 2-day intervals for 11 days. …

    Nano Biomedicine 12(2), 69-76, 2020

    J-STAGE 

  • Long-Term Management of a Periodontal Disease Patient with Diabetes Mellitus by a Dental Hygienist  [in Japanese]

    Okabe Sanae , Nagano Takatoshi , Gomi Kazuhiro

    <p>歯周病は感染症であると同時に生活習慣病であり,様々な全身疾患と関わりを持つ疾患である。特に糖尿病とは相互に影響を与えるなど密接な関わりがある。本症例は,2型糖尿病を有する広汎型重度慢性歯周炎患者に対し,17年間定期的な管理,良好なコミュニケーションを継続し,安定した状態を維持している一症例を報告する。</p><p>患者は40歳男性で,2001年11月に歯周 …

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 62(4), 225-233, 2020

    J-STAGE 

  • Gonadal development and ovipositor morphology in the oily gudgeon, <i>Sarcocheilichthys variegatus variegatus</i>  [in Japanese]

    Ban Masayoshi , Koya Yasunori

    … This study investigated annual changes in gonadal histology, and ovipositor morphology in the oily gudgeon, <i>Sarcocheilichthys variegatus variegatus</i>, so as to throw further light on the process of gonadal development in cyprinid fishes and the evolution of structures related to eggs deposition into bivalves. …

    Japanese Journal of Ichthyology 67(2), 179-193, 2020

    J-STAGE 

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