Search Results 1-20 of 517

  • The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation

    Akinori Takahashi , Toru Suzuki , Shou Soeda , Shohei Takaoka , Shungo Kobori , Tomokazu Yamaguchi , Haytham Mohamed Aly Mohamed , Akiko Yanagiya , Takaya Abe , Mayo Shigeta , Yasuhide Furuta , Keiji Kuba , Tadashi Yamamoto

    … Here, we show that the CCR4-NOT deadenylase complex maintains expression of mRNAs, such as those encoding transcription factors, cell cycle regulators, DNA damage response-related proteins, and metabolic enzymes, at appropriate levels in the liver. …

    Life Science Alliance 3(5), e201900494, 2020-04-01


  • Multiple roles of hypoxia in bovine corpus luteum

    NISHIMURA Ryo , OKUDA Kiyoshi

    … There has been increasing interest in the role of hypoxia in the microenvironment of organs, because of the discovery of hypoxia-inducible factor-1 (HIF1), which acts as a transcription factor for many genes activated specifically under hypoxic conditions. … The ovary changes day by day during the estrous cycle as it goes through phases of follicular growth, ovulation, and formation and regression of the corpus luteum (CL). …

    Journal of Reproduction and Development 66(4), 307-310, 2020


  • The potential role of lncRNAs in diabetes and diabetic microvascular complications

    Chen Yanxia , He Yinxi , Zhou Hong

    … Becasuse of which these RNAs have no significant protein-coding potential, they were initially considered as "junk-products" of transcription without biological meaning. … Nevertheless, recent research advancements have shown that lncRNAs are involved in many physiological processes such as cell cycle regulation, cell apoptosis and survival, cancer migration and metabolism. …

    Endocrine Journal 67(7), 659-668, 2020


  • KLF5 regulates chicken skeletal muscle atrophy via the canonical Wnt/β-catenin signaling pathway

    ZHANG Dong-Hao , YIN Hua-Dong , LI Jing-Jing , WANG Yan , YANG Chao-Wu , JIANG Xiao-Song , DU Hua-Rui , LIU Yi-Ping

    … <p>Recent studies in mice suggested that KLF5 (Kruppel like factor 5), a zinc-finger transcription factor, plays an important role in skeletal muscle development and regeneration. … As an important factor in the process of muscle development, KLF5 participates in the regulation of the cell cycle, cell survival, and cell dryness under different environmental conditions, but it is not clear whether KLF5 participates in muscle atrophy. …

    Experimental Animals, 2020


  • Overexpression of the response regulator <i>rpaA</i> causes an impaired cell division in the Cyanobacterium <i>Synechocystis</i> sp. PCC 6803

    Kizawa Ayumi , Osanai Takashi

    … <p>In photosynthetic microorganisms, cell cycle progression depends on day and night cycles; …

    The Journal of General and Applied Microbiology 66(2), 121-128, 2020


  • Characterization of the human <i>E2F4</i> promoter region and its response to 12-<i>O</i>-tetradecanoylphorbol-13-acetate  [in Japanese]

    Asai Masashi , Hamada Hiroshi , Osamura Naoya , Kirinoki Yoriko , Uchiumi Fumiaki

    … <p>The E2F transcription factors (TFs), which control the progression of the cell cycle in response to DNA damage and various stresses, are known to interact with a tumour suppressor, Retinoblastoma 1 (RB1). … gene and the protein, which possibly acts as a cell cycle accelerator, was greatly diminished.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-253, 2020


  • Expression and localization of cellular FLICE-like inhibitory protein (cFLIP), an anti-apoptotic factor, in corpora lutea during the estrous cycle and pregnancy in Thai swamp buffalo <i>(Bubalus bubalis)</i>

    WONGPANIT Kannika , MANABE Noboru

    … To gain further insights into the role of cellular FLICE-like inhibitory protein (cFLIP), an anti-apoptosis factor that is structurally similar to procaspase-8 but lacks proteolytic enzyme activity, we examined the expression in CLs of Thai swamp buffalos (<i>Bubalus bubalis</i>) during the early, mid, and late stage of the estrous cycle and pregnancy. …

    Journal of Reproduction and Development 66(1), 29-33, 2020


  • Analysis of the anti-tumor mechanism of BRD4 inhibition in hepatocellular carcinoma

    Hajime SASAKI , Hiroshi KITAJIMA , Takeshi NIINUMA , Hideki WAKASUGI , Kazuya ISHIGURO , Akira YOROZU , Gouta SUDO , Tomo HATAHIRA , Noriyuki AKUTU , Eiichiro YAMAMOTO , Masahiro KAI , Shigeru SASAKI , Hiroshi NAKASE , Hiromu SUZUKI

    … Bromodomain and extra terminal (BET) family proteins, which include BRD4, are readers of histone acetyl-lysines and key regulators of gene transcription. … We first tested the effects of the BRD4 inhibitor JQ1 in a series of 9 HCC cell lines and found that it strongly suppressed HCC cell proliferation by inducing cell cycle arrest and apoptosis. …

    札幌医学雑誌 88(1-6), 21-35, 2019-12

    IR  DOI  Ichushi Web 

  • Interconnection between circadian clocks and thyroid function

    Ikegami Keisuke , Refetoff Samuel , Van Cauter Eve , Yoshimura Takashi

    … Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by transcription–translation feedback loops of specific genes, which are referred to as 'circadian clock genes'. … Disruption of circadian rhythms has been recognized as a perturbation of the endocrine system and of cell cycle progression. …

    Nature Reviews Endocrinology 15(10), 590-600, 2019-10


  • Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by tumor necrosis factor-like ligand 1A using cDNA microarray analysis

    Fukuda Koji , Miura Yasushi , Maeda Toshihisa , Hayashi Shinya , Kuroda Ryosuke

    … Among the genes in this profile, the present study focused on the following genes: Spectrin repeat-containing nuclear envelope 1, Fc receptor-like 2, PYD (pyrin domain)-containing 1, cell division cycle 45 homolog, signal transducer and activator of transcription 5B, and interferon regulatory factor 4. …

    Biomedical Reports 11(1), 11-18, 2019-07


  • Gap 2 phase: making the fundamental decision to divide or not

    Umeda Masaak , Shiori S Aki , Naoki Takahashi

    … The Gap phases of the cell cycle are essential to perceive internal and external signals and control cell division and differentiation. … In this review, we summarize recent findings about core G2-phase regulators, such as B-type cyclin-dependent kinases (CDKs) and R1R2R3-type MYB transcription factors. …



  • A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

    Takahashi Naoki , Ogita Nobuo , Takahashi Tomonobu , Taniguchi Shoji , Tanaka Maho , Seki Motoaki , Umeda Masaaki

    … Cell cycle arrest is an active response to stresses that enables organisms to survive under fluctuating environmental conditions. … While signalling pathways that inhibit cell cycle progression have been elucidated, the putative core module orchestrating cell cycle arrest in response to various stresses is still elusive. … Here we report that in Arabidopsis, the NAC-type transcription factors ANAC044 and ANAC085 are required for DNA damage-induced G2 arrest. …



  • States of decay: The systems biology of mRNA stability

    William Ashworth , Patrick N. Stoney , Tadashi Yamamoto

    … An appropriate equilibrium between transcription and mRNA decay is vital for the function of the cell. … The RNA-binding complexes regulating mRNA degradation, such as carbon catabolite repression 4-negative on TATA-less, may also control several other stages of the mRNA life cycle, from transcription to translation. …

    Current Opinion in Systems Biology (15), 48-57, 2019-03-19


  • Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes

    Toru Suzuki , Chisato Kikuguchi , Saori Nishijima , Takeshi Nagashima , Akinori Takahashi , Mariko Okada , Tadashi Yamamoto

    … Cnot3(-/-) livers show increased expression of immune response-related, cell cycle-regulating and immature liver genes, while many genes relevant to liver functions, such as oxidation-reduction, lipid metabolism and mitochondrial function, decrease, indicating impaired liver functional maturation. … In contrast, transcription of liver function-related mRNAs was lower in Cnot3(-/-) livers. …

    Development 146(4), dev168146, 2019-02-15


  • Casein kinase II–dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast

    Norihiko Nakazawa , Orie Arakawa , Masahiro Ebe , Mitsuhiro Yanagida

    … DNA topoisomerase II (topo II) regulates the topological state of DNA and is necessary for DNA replication, transcription, and chromosome segregation. … Consistent with the constitutive activity of Cka1/CKII, Ser(1363) and Ser(1364) phosphorylation of topo II was stably maintained throughout the cell cycle. …

    Journal of Biological Chemistry 294(10), 3772-3782, 2019-01-11


  • Milk basic protein promotes proliferation and inhibits differentiation of mouse chondrogenic ATDC5 cells

    中谷 祥恵 , 田口 陽介 , 上田 博也 , 石田 祐子 , 森田 如一 , 加藤 健 , 和田 政裕 , 古旗 賢二

    … The cell cycle analysis using flow-cytometry revealed that the proportion of S- and G2/M-phase cells was increased but that of G0/G1 phase was decreased in a dose-dependent manner with MBP addition. … In the reverse-transcription PCR experiment, the mRNA level of SRY-box containing gene 9 (Sox9) and type II collagen (Col2) was significantly increased in the MBP-treated cells compared with the control cells. …

    Journal of Dairy Science 102(4), 2873-2878, 2019-01


  • <i>O</i>-GlcNAcylation stabilizes FOXM1 protein via suppression of its poly-ubiquitination  [in Japanese]

    Moriwaki Kazumasa , Ueda Yasuhiro , Higuchi Kazuhide , Asahi Michio

    … In this study, we examined <i>O</i>-GlcNAcylation-mediated cancer cell proliferation focusing on FOXM1 oncogenic transcription factor to regulate cell cycle. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-P-094, 2019


  • Melarsomine suppresses canine osteosarcoma cell survival via inhibition of Hedgehog-GLI signaling

    NAM Aryung , KIM Taewon , LI Qiang , REBHUN Robert B. , YOUN Hwa-Young , SEO Kyoung-Won

    … Melarsomine-induced apoptotic cell death was assessed via cell cycle analysis using propidium iodide staining. … Quantitative real-time reverse transcription polymerase chain reaction and western blot analyses revealed a downregulation of genes downstream of the Hedgehog signaling pathway, including <i>GLI1</i>, <i>GLI2</i>, and <i>PTCH</i>, after melarsomine treatment. …

    Journal of Veterinary Medical Science 81(12), 1722-1729, 2019

    J-STAGE  Ichushi Web 

  • Laboratory Evaluation of Rapid Antigen Detection Tests for More-Sensitive Detection of Respiratory Syncytial Virus Antigen

    Sun Yu , Deng Jie , Qian Yuan , Zhu Runan , Wang Fang , Tian Run , De Ri , Zhao Linqing

    … The swabs were evaluated using the aforementioned RADTs, the reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR), and the direct immunofluorescence assay (DFA). … The optimal critical cycle threshold (Ct) values on RT-qPCR that correlated with Sofia<sup>®</sup> …

    Japanese Journal of Infectious Diseases 72(6), 394-398, 2019

    J-STAGE  Ichushi Web 

  • Discovery of a Robust Gene Regulatory Network with a Complex Transcription Factor Network on Organ Cancer Cell-line RNA Sequence Data

    Kalbuaji Bharata , Taguchi Y-H. , Konagaya Akihiko

    … One of the most important interactions is a regulatory interaction that involves transcription factor genes. … In this research, we are attempting to construct a new regulatory network that imitates the transcription and translation processes of mRNA. … We believe that the transcription factor genes found in intersection sub-networks may reveal an important mechanism that affects cancer cell growth. …

    Chem-Bio Informatics Journal 19(0), 32-55, 2019


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