Search Results 1-20 of 3829

  • From rioting to boycotting : a public sphere of beer in 19th century Munich  [in Japanese]

    東風谷 太一 , コチヤ タイチ , Kochiya Taichi

    … This paper analyses the factors that led an popular disorder called Beer Riot in Munich 1844 to the Beer Boycott in two years. …

    社会科学 = The Social Science(The Social Sciences) 49(4), 161-189, 2020-02-28

    IR  DOI 

  • HTLV-1 bZIP factor: the key viral gene for pathogenesis

    Matsuoka Masao , Mesnard Jean-Michel

    … HBZ protein suppresses transcription of the tax gene through blocking the LTR recruitment of not only ATF/CREB factors but also CBP/p300. … HBZ promotes transcription of Foxp3, CCR4, and T-cell immunoreceptor with Ig and ITIM domains (TIGIT). …

    Retrovirology (17), 2020-01-08


  • Claudin 4 in pancreatic β cells is involved in regulating the functional state of adult islets

    Li Hongtu , Neelankal John Abraham , Nagatake Takahiro , Hamazaki Yoko , Jiang Fang‐Xu

    … The functional state (FS) of adult pancreatic islets is regulated by a large array of regulatory molecules including numerous transcription factors. …

    FEBS Open Bio 10(1), 28-40, 2020-01


  • Pathological mechanisms and novel therapeutic outlooks for sepsis-associated acute lung injury  [in Japanese]

    Hattori Yuichi , Hattori Kohshi , Matsuda Naoyuki

    … Sepsis alters expression of many pathogenic factors that can potentially give rise to abnormalities in the respiratory system. … A number of transcription factors, such as nuclear factor-kappaB and activator protein-1, can be linked to the altered gene activation during sepsis. … Thus, several transcription factors may play a pivotal role in the pathophysiology of acute lung injury in sepsis. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S34-3, 2020


  • Expression profile of xenobiotic efflux transporters in mouse neural stem cells  [in Japanese]

    Takata Kenya , Ishimoto Takahiro , Masuo Yusuke , Kato Yukio

    … We also characterized the NSCs by evaluating mRNA expression of basic helix-loop-helix (bHLH) transcription factors which regulate neuronal differentiation. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-368, 2020


  • TRPM2 channel regulates tumor angiogenesis via interacting with Stat3  [in Japanese]

    Ryuhei Kurogi , Ueda Yoshifumi , Yamada Yuji , Hasegawa Yoshiaki , Mori Yasuo

    … Especially, tumor-associated macrophages (TAMs) are one of the major components of tumor tissues, and they play pivotal roles in prompting the various tumor growths by producing growth factors. … In addition, TAMs isolated from TRPM2 knock out mice showed strong expression of proangiogenic factor VEGF according to the enhanced activity of transcription factor Stat3. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-356, 2020


  • Unveiling the impact of epigenetic regulation in disease pathogenesis with iPS cell technology  [in Japanese]

    Yasuhiro Yamada

    … We show that the transient expression of reprogramming factors in pancreatic acinar cells results in the transient repression of acinar cell enhancers, which are similarly observed in pancreatitis. … Notably, the transient expression of reprogramming factors in <i>Kras</i> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-JPS-3, 2020


  • Characterization of the human <i>E2F4</i> promoter region and its response to 12-<i>O</i>-tetradecanoylphorbol-13-acetate  [in Japanese]

    Asai Masashi , Hamada Hiroshi , Osamura Naoya , Kirinoki Yoriko , Uchiumi Fumiaki

    … <p>The E2F transcription factors (TFs), which control the progression of the cell cycle in response to DNA damage and various stresses, are known to interact with a tumour suppressor, Retinoblastoma 1 (RB1). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-253, 2020


  • Epigenomic regulation of prefrontal microglia induced by social defeat stress  [in Japanese]

    Taniguchi Masayuki , Kitaoka Shiho , Kuraku Shigehiro , Kadota Mitsutaka , Furuayshiki Tomoyuki

    … We are currently investigating transcription factors related to regulation of mPFC microglial epigenomic changes associated with emotional changes.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-170, 2020


  • C3orf70 is associated with neural and neurobehavioral development  [in Japanese]

    Miura Koki , Ashikawa Yoshifumi , Shiromizu Takashi , Adachi Yuka , Tanaka Toshio , Nishimura Yuhei

    … In this study, we performed a comparative transcriptomic analysis to reveal common targets of the proneural transcription factors, Neurog1/2 or Ascl1, during neurogenesis of human and mouse stem cells. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-162, 2020


  • Genetic basis of myelodysplastic syndromes

    OGAWA Seishi

    … The most frequently affected molecules are involved in DNA methylations, chromatin modification, RNA splicing, transcription, signal transduction, cohesin regulation, and DNA repair. …

    Proceedings of the Japan Academy, Series B 96(3), 107-121, 2020


  • Brain and Neuronal Aging: Aged Brain Controls <i>via</i> Gene Expression Fidelity and Master Regulatory Factors  [in Japanese]

    Mori Nozomu

    … In both neurodegeneration and protein quality controls, various proteins are involved in their regulation, but recent evidence suggests that repressor element-1 silencing transcription factor (REST) could be a master regulatory protein that is crucial for orchestrating the neural protecting events in human brain aging. …

    YAKUGAKU ZASSHI 140(3), 395-404, 2020


  • Melatonin protects against Epirubicin-induced ovarian damage

    WANG Naiqiang , LI Hua , ZHU Yunqing , LI Na , CHEN Zi-Jiang , ZHANG Cong

    … while it upregulated antiapoptotic factors <i>Bcl-2</i> … In addition, melatonin markedly reduced reactive oxygen species (ROS) and the transcription of <i>Caspase12</i> …

    Journal of Reproduction and Development 66(1), 19-27, 2020


  • Multiple consequences of HIF activation in CKD  [in Japanese]

    Tanaka Tetsuhiro

    … Studies on erythropoietin (EPO) transcription led to the identification of hypoxia inducible factors (HIFs) and their key regulators, prolyl hydroxylases (PHDs). …

    Folia Pharmacologica Japonica 155(1), 30-34, 2020


  • Investigation of Drug-induced Lung Injury for the Development of a Novel Therapeutic Approach  [in Japanese]

    Kawami Masashi

    … In addition, our results showed that certain secreted factors and microRNAs, a class of small noncoding RNAs, may be involved in MTX-induced EMT. … COA-Cl significantly suppressed TGF-β1-induced EMT-like phenotypic changes, as evidenced by the inhibition of EMT-related transcription factors. …

    YAKUGAKU ZASSHI 140(1), 15-22, 2020


  • The present situation and risk factors of child abuse and neglect  [in Japanese]

    笹川 宏樹 , ササカワ ヒロキ , Sasakawa Hiroki

    短報児童虐待は著しく増加し深刻な状況にあり,公認心理師を含む多職種のチームアプローチが期待されている。本稿では,それらの連携の基礎となる児童虐待の現状と,リスク要因について概説することを目的とした。平成30年度の全国の児童虐待対応件数は,159,850件であり過去最高であった。また平成29年度の虐待による死亡事例は50例(52人)であり深刻な状況にあった。これまでの調査の結果から,児童虐待の子ども …

    心理臨床科学 = Doshisha Clinical Psychology : therapy and research 9(1), 31-38, 2019-12-15

    IR  DOI 

  • An exploratory research for ACT intervention for alcohol-related problems : focus on psychological related factors  [in Japanese]

    𠮷川 翔 , 武藤 崇 , ヨシカワ ショウ , ムトウ タカシ , Yoshikawa Sho , Muto Takashi

    研究論文本研究の目的は,飲酒問題の重篤度によって,不安,抑うつや孤独感といった心理的関連因子と,アクセプタンス&コミットメント・セラピー(以下,ACT)関連因子に差があるかを探索的に調査することであった。本研究では,40-60歳の男女1,176名を飲酒問題の重篤度によって分類し,1)不安,抑うつ,孤独感などの心理的関連因子の程度に差が存在するのかまた,アルコール依存症に対してACT介入の効果が認め …

    心理臨床科学 = Doshisha Clinical Psychology : therapy and research 9(1), 3-13, 2019-12-15

    IR  DOI 

  • GEMMA CUP-ASSOCIATED MYB1, an Ortholog of Axillary Meristem Regulators, Is Essential in Vegetative Reproduction in Marchantiapolymorpha

    Yasui Yukiko , Tsukamoto Shigeyuki , Sugaya Tomomi , Nishihama Ryuichi , Wang Quan , Kato Hirotaka , Yamato Katsuyuki T. , Fukaki Hidehiro , Mimura Tetsuro , Kubo Hiroyoshi , Theres Klaus , Kohchi Takayuki , Ishizaki Kimitsune

    … Here we report an R2R3-MYB transcription factor, designated GEMMA CUP-ASSOCIATED MYB1 (GCAM1), which is an essential regulator of gemma cup development in M. …

    Current Biology 29(23), 3987-3995.e5, 2019-12-02


  • Encouraging Self-reliance in Children under In-care of Children's Home : A Study Based on Interviews with Aftercare Social Workers  [in Japanese]

    梅谷 聡子 , ウメタニ サトコ , Umetani Satoko

    … I analyzed aftercare social workers' narratives, focusing on the difficulties experienced by the care leavers ; the factors causing difficulties for care leavers ; care leavers' strengths in problem-solving ; and the support necessary to encourage children's self-reliance during in-care. …

    評論・社会科学 = Social science review (131), 95-121, 2019-12

    IR  DOI 

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