Search Results 1-20 of 1755

  • Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells

    Nawara Hend M. , Afify Said M. , Hassan Ghmkin , Zahra Maram H. , Atallah Marwa N. , Mansour Hager , Abu Quora Hagar A. , Alam Md Jahangir , Osman Amira , Kakuta Hiroki , Hamada Hiroki , Seno Akimasa , Seno Masaharu

    … Combination therapy, which is a treatment modality combining two or more therapeutic agents, is considered a cornerstone of cancer therapy. …

    Cancers 12(6), 1360, 2020-05-26


  • Sensitive Photodynamic Detection of Adult T-cell Leukemia/Lymphoma and Specific Leukemic Cell Death Induced by Photodynamic Therapy: Current Status in Hematopoietic Malignancies

    Oka Takashi , Matsuoka Ken-Ichi , Utsunomiya Atae

    … ALA-PDT/PDD can be promising as a novel treatment modality that overcomes unmet medical needs with the optimization of PDT parameters to increase the effectiveness of the tumor-killing activity and enhance the innate and adaptive anti-tumor immune responses by the optimized immunogenic cell death. …

    Cancers 12(2), 335, 2020-02-02


  • Differences in Intravascular Ultrasound Measurement Values Between Treatment Modalities for Restenosis in Femoropopliteal Lesions

    Aihara Hideaki , Sakurai Masayuki , Murata Naotaka , Fujimoto Yo , Kikuchi Arifumi , Koganei Hiroshi , Sato Akira , Noguchi Yuichi , Ieda Masaki , Higashitani Michiaki , Takimura Hideyuki , Tobita Kazuki , Jujo Kentaro , Hozawa Koji , Yamaguchi Tetsuo , Iwata Yo , Tokuyama Hideo

    … In the case of stent use, a larger distal plaque burden was associated with restenosis, while a lower calcification angle was associated with higher patency in the case of balloon angioplasty alone.</p><p><b><i>Conclusions:</i></b>The factors related to patency differed depending on the treating modality. …

    Circulation Journal 84(8), 1320-1329, 2020


  • Percutaneous Image-guided Thermal Ablation for Renal Cell Carcinoma

    Fujimori Masashi , Yamanaka Takashi , Sugino Yuichi , Matsushita Naritaka , Sakuma Hajime

    … <p>Nephrectomy is the gold standard for the treatment of renal cell carcinoma (RCC). … Percutaneous image-guided thermal ablation, including cryoablation and radiofrequency ablation, is a minimally invasive and highly effective treatment and can be used to treat RCC in patients who are not good candidates for surgery. …

    Interventional Radiology 5(2), 32-42, 2020


  • How Can Refractory Ulcers be Treated with Surgery?:The Role of Wound Surgeons in Debridement

    Motomura Hisashi , Deguchi Ayaka , Hatano Takaharu , Fujikawa Heishiro , Maeda Shusaku , Nobuyama Ayami

    … Foot ulcers due to diabetes or/and arteriosclerosis obliterans frequently result in an intractable condition which is refractory to treatment. … In order to overcome such a condition, establishing a treatment modality based on the tissue, infection/inflammation, moisture balance, and edge of wound (TIME) concept to clinically perform wound bed preparation (WBP), as advocated by Schulz, is important. …

    International Journal of Surgical Wound Care 1(1), 3-8, 2020


  • The State of Diabetic Care Behavior of Japanese Pediatric Patients With Type 1 Diabetes - The Effects of Insulin Pump Therapy and Age -  [in Japanese]

    Matsui Katsuyuki , Tsuda Tomoko , Tagawa Koji , Mimura Yu , Shibata Masami , Tsutusi Hidemi , Mori Asami , Maruo Yoshihiro

    … These results demonstrate the effects of the CSII treatment modality and age on the diabetic care behavior of pediatric patients.</p> …

    Journal of the Japan Diabetes Society 63(5), 315-323, 2020


  • Preoperative image diagnosis of follicular lesions by multi-modality  [in Japanese]

    Shimode Yuzo , Kawakami Osamu , Kobayashi Yoshiaki , Ishisaka Tomo , Okano Keiichiro , Takaoka Yuki , Noda Takuya , Matoba Munetaka , Tsuji Hiroyuki

    … Based on the possibility of application to multi-modality imaging, we report the results of our study.<br>Patients with thyroid follicular lesions and benign nodular lesions who underwent surgery in our department between March 2015 and July 2018 were targeted. … The multi-modality assessment was considered to contribute to treatment strategies for follicular lesions. …

    Toukeibu Gan 46(1), 52-58, 2020


  • Administration of methotrexate(MTX)for a patient with missed abortion after transabdominal cerclage(TAC)  [in Japanese]

    Ishido Manami , Ishioka Shinichi , Fujibe Yuya , Suzuki Miki , Shimada Hiroshi , Mariya Tasuku , Baba Tsuyoshi , Saito Tsuyoshi

    … Fetal and villus components were completely excreted after 3courses of MTX treatment without any troubles. … Blood hCG level also became normal after the treatment. … This patient conceived again after MTX treatment and got a healthy baby of 1,912g at 33 weeks of pregnancy by scheduled cesarean section. … Administration of MTX might be an useful treatment modality for patients with these conditions.</p> …

    Journal of Japan Society of Perinatal and Neonatal Medicine 56(1), 198-202, 2020


  • Epigenetic Drug Discovery by Artificial Genetic Switches  [in Japanese]

    Bando Toshikazu , Sugiyama Hiroshi

    … are maintained under such control, it is effective for cell reprogramming, differentiation induction, disease treatment, etc. … PI polyamide can be described to be a new modality different from conventional low molecular weight compounds, antibody drugs, and nucleic acid drugs that have recently attracted attention. …

    Journal of Synthetic Organic Chemistry, Japan 78(5), 476-484, 2020


  • Evaluation of Mucopexy-Recto Anal Lifting (MuRAL): A New Method for Treating Hemorrhoids

    Shimojima Yasuhiro , Okamoto Kosuke , Fukano Masahiko , Kuromizu Joji , Matsushima Makoto , Matsushima Sayuri , Watanabe Yotaro , Beniya Ayumi , Hikosaka Yoshioki , Katori Remi , Matsumura Naomi , Kono Yoichi

    … <p>Objectives: Ligation and excision remain the commonly recognized standard surgical modality for treating hemorrhoids. … Further, impediments to surgical treatment owing to social factors and the need for minimally invasive procedures and other confounders have resulted in the adoption of the mucopexy-recto anal lifting (MuRAL) method which is associated with favorable outcomes. …

    Journal of the Anus, Rectum and Colon 4(2), 51-58, 2020


  • Efficacy and safety of stem cells transplantation in patients with type 1 diabetes mellitus—a systematic review and meta-analysis

    Wu Qian , Zheng Shuai , Qin Yao , Zheng Xuqin , Chen Heng , Yang Tao , Zhang Mei

    … <p>Stem cells (SCs) therapy is a new promising therapeutic modality for type 1 diabetes (T1DM). … The higher GADA positive rate before treatment also significantly associated with the decrease of daily insulin requirement. …

    Endocrine Journal, 2020


  • Acute-phase treatment of cerebrovascular disease  [in Japanese]

    Morita Kotaro

    … Knowing the current state of acute-phase treatment is useful for rehabilitation approaches and predicting the course of symptoms. … Since the beginning of this century, the treatment modality has dramatically changed with the progress of various medical devices, and as a result, the improvement of the outcome has been realized. …

    Japanese Journal of Neuropsychology 36(1), 25-34, 2020


  • Ruptured Basilar Artery Dissection Diagnosed Using Magnetic Resonance Vessel Wall Imaging and Treated with Coil Embolization with Overlapping LVIS Stents: A Case Report

    Sonobe Shinya , Yoshida Masahiro , Niizuma Kuniyasu , Tominaga Teiji

    … <p>The diagnosis and treatment of patients with ruptured basilar artery dissection (rBAD) are often difficult. … MR-VWI has attracted attention as a useful modality for detecting a ruptured lesion in patients with subarachnoid hemorrhage. …

    NMC Case Report Journal 7(2), 75-79, 2020


  • MRI Connecting Functions and Anatomy: A New Bridge for Radiotherapy  [in Japanese]

    IIMA Mami , TOGASHI Kaori , IIZUKA Yusuke , MATSUO Yukinori , TAKAYAMA Kenji , NAKAMOTO Yuji , YAMAMOTO Akira , KATAOKA Masako , ISHIMORI Takayoshi , MIZOWAKI Takashi

    … For several decades, CT has been established as the gold standard modality for the treatment planning of radiotherapy, while MRI has emerged as a tool to evaluate the functional characteristics of tumors without radiation exposure. … In this regard, MRI, as a modality without the need for a contrast agent, may allow more frequent scans and more detailed dose painting, such as increasing the dose to viable lesion parts while reducing the dose to less aggressive parts. …

    Japanese Journal of Medical Physics (Igakubutsuri) 40(1), 3-7, 2020


  • Staged resection and local intralesional triamcinolone acetonide injection to prevent postoperative stricture for multiple superficial hypopharyngeal cancer : a case report  [in Japanese]

    Mukai Masayoshi , Eguchi Kohtaro , Shirakura Satoshi , Sugimoto Taro

    … The treatment modality should be carefully chosen based on the patient's age, past history, tumor site, and tumor invasion depth. … Here, we present the case of a 75-year-old man with a history of endoscopic treatment for superficial esophageal cancer. …


    J-STAGE  Ichushi Web 

  • Mechanical Circulatory Support for Patients With Adult Congenital Heart Disease

    Haranal Maruti , Luo Shuhua , Honjo Osami

    … Mechanical circulatory support (MCS) devices have evolved as an alternative treatment modality in supporting the failing myocardium of this population, but are often used less frequently than in those with a structurally normal heart because of the unique anatomical and physiological variations. …

    Circulation Journal 84(4), 533-541, 2020


  • Establishment of orthotopic transplantation model of mouse gallbladder cancer organoid for development and efficacy evaluation of anti-tumor agents.  [in Japanese]

    Shingo Kato , Matsuura Tetsuya , Kurotaki Daisuke , Hippo Yoshitaka , Tamura Tomohiko , Nakajima Atsushi

    … Additionally, considering that immunotherapy has emerged as a promising new modality of treatment for biliary tract cancers, to develop animal models that can analyze host immune response against cancer is becoming more important. … Finally, the treatment of orthotopic transplant model by gemcitabine significantly decreased tumor volumes. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-122, 2020


  • Radiomics for Head-and-Neck Cancer  [in Japanese]

    KAMEZAWA Hidemi

    … Conventional head-and-neck cancer treatment employs a standard therapy (one-size-fits-all approach), in which a specific treatment approach is applied to all patients who have the same cancer without taking into the cancer traits of each patient. … Radiomics is a novel research field that analyzes the relationships between the many phenotypic (image) features, which were extracted from multi-modality images such as computed tomography and magnetic resonance images, and clinical outcomes. …

    Medical Imaging Technology 38(1), 10-14, 2020

    J-STAGE  Ichushi Web 

  • Spinal Epidural Abscess: A Review Highlighting Early Diagnosis and Management

    Tetsuka Syuichi , Suzuki Tomohiro , Ogawa Tomoko , Hashimoto Ritsuo , Kato Hiroyuki

    … The most important prognostic factor for a favorable outcome is early diagnosis and appropriate treatment. … Gadolinium-enhanced MRI is the most sensitive, specific, and beneficial imaging modality for establishing a diagnosis of SEA. …

    JMA Journal 3(1), 29-40, 2020


  • Stratification by Multidimensional Approach for Rational Treatment of Asymptomatic Carotid Stenosis (SMART-K Study): Study Protocol

    YOSHIDA Kazumichi , MIYAMOTO Susumu , SMART-K Study Group

    … Accurate stratification of ACS should be based on the risk of cerebral infarction, and subgroups of patients more likely to benefit from surgical treatment should be differentiated. … Magnetic resonance imaging (MRI) offers a non-invasive, accurate modality for characterizing carotid plaque. … The study population comprises patients with ACS (>60% area stenosis) associated with MRI-diagnosed IPH receiving follow-up under medical treatment. …

    Neurologia medico-chirurgica 60(1), 10-16, 2020


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