Search Results 1-20 of 34270

  • P40 expression in small cell lung cancer: The presence of p40-positive cells does not always indicate squamous differentiation

    Nakajima Naoki , Yoshizawa Akihiko , Moriyoshi Koki , Sonobe Makoto , Menju Toshi , Sumiyoshi Shinji , Date Hiroshi , Haga Hironori

    … Background: Small cell lung cancer (SCLC) is normally diagnosed with hematoxylin and eosin stains, although some cases require immunohistochemistry (IHC). … P40 is highly sensitive and specific for squamous cell carcinoma and is thus considered the best marker for this cancer. … 1% of tumor cells. … In the remaining five cases, 1–5% of tumor cells expressed p40, and in three of these, the cells expressing p40 also expressed TTF‐1 and neuroendocrine markers. …

    Thoracic Cancer 10(5), 1188-1192, 2019-05

    IR

  • Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5

    Nishikawa Gen , Kawada Kenji , Nakagawa Jun , Toda Kosuke , Ogawa Ryotaro , Inamoto Susumu , Mizuno Rei , Itatani Yoshiro , Sakai Yoshiharu

    … Mesenchymal stem cells (MSCs) are recruited from BM to the stroma of developing tumors, where they serve as critical components of the tumor microenvironment by secreting growth factors, cytokines, and chemokines. … A relatively strong CCR5 expression could be detected within the cytoplasm of several CRC cell lines. … Notably, the CCR5 inhibitor, maraviroc, significantly abolished the MSC-induced tumor growth in vivo. …

    Cell Death & Disease (10), 2019-04-01

    IR

  • A Case of Primary Testicular Mucinous Carcinoma  [in Japanese]

    多賀 英人 , 細川 洋平 , 真鍋 俊明 , 萩原 暢久 , 山田 剛司 , 岩田 健 , 宮下 浩明

    … His carbohydrate antigen 19-9 and carcinoembryonic antigen levels were elevated but his germ cell tumor markers were not high. … Since no tumor was found by the endoscopy of the upper gastrointestinal and the lower digestive tract, we diagnosed the patient with primary testicular mucinous carcinoma. …

    泌尿器科紀要 = Acta urologica Japonica 65(3), 87-91, 2019-03-31

    IR DOI

  • A study of the relationship between the pineal, immune mechanisms and cancer ─ a historical survey 1. Immunocytes in the pineal region and the relationship between the pineal and cancer  [in Japanese]

    加地 隆 , 加地 眸

    … Following the brief explanation on research histories of pineal, cellular immunology, etc., EM studies on Langerhans cells by Hoshino and the dendritic cell research by Steinman were introduced. … Kachi et al reported about the pineal-adrenomedullary relation and its possible influence on tumor growth. …

    弘前医療福祉大学紀要 10(1), 1-13, 2019-03-28

    IR

  • Stereotactic Body Radiotherapy for Lung Tumors : Basic Principles and Clinical Results

    Aoki Masahiko , Hatayama Yoshiomi , Kawaguchi Hideo , Sato Mariko , Tanaka Mitsuki , Fujioka Ichitaro , Ichise Koji , Hirose Katsumi , Takai Yoshihiro

    … The precise and accurate delivery of multiple radiation beams to the target maximizes tumor cell death while keeping the dose to the surrounding normal tissue to a minimum. … This review defines SBRT and presents the history of its technical development for safe and effective administration, as well as the clinical results of using SBRT to treat early-stage non-small cell lung cancer and lung metastases. …

    弘前医学 69(1-4), 1-9, 2019-03-15

    IR

  • A Consideration on Improvement of Detection Efficiency for Circulating Tumor Cell Using Ring-resonator Type of Electrode  [in Japanese]

    空 翔太 , 熊原 宏征 , 黒木 太司 , 江口 正徳 , 山川 烈 , 田中 文啓

    電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 118(507), 145-149, 2019-03-14

  • A Consideration on Improvement of Detection Efficiency for Circulating Tumor Cell Using Ring-resonator Type of Electrode  [in Japanese]

    空 翔太 , 熊原 宏征 , 黒木 太司 , 江口 正徳 , 山川 烈 , 田中 文啓

    電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 118(506), 145-149, 2019-03-14

  • Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor

    Terada Yukinori , Jo Norihide , Arakawa Yoshiki , Sakakura Megumi , Yamada Yosuke , Ukai Tomoyo , Kabata Mio , Mitsunaga Kanae , Mineharu Yohei , Ohta Sho , Nakagawa Masato , Miyamoto Susumu , Yamamoto Takuya , Yamada Yasuhiro

    ヒトiPS細胞を使った小児脳腫瘍の病態解明 --新しい治療標的を同定--. 京都大学プレスリリース. 2019-03-06.

    Cell Reports 26(10), 2608-2621, 2019-03-05

    IR

  • Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

    Muraoka Daisuke , Seo Naohiro , Hayashi Tae , Tahara Yoshiro , Fujii Keisuke , Tawara Isao , Miyahara Yoshihiro , Okamori Kana , Yagita Hideo , Imoto Seiya , Yamaguchi Rui , Komura Mitsuhiro , Miyano Satoru , Goto Masahiro , Sawada Shin-ichi , Asai Akira , Ikeda Hiroaki , Akiyoshi Kazunari , Harada Naozumi , Shiku Hiroshi

    … however, many patients are refractory to these immunotherapies, and the mechanisms underlying tumor immune resistance have not been fully elucidated. … By comparing the tumor microenvironment of checkpoint inhibition-sensitive and -resistant murine solid tumors, we observed that the resistant tumors had low immunogenicity. … We identified antigen presentation by CD11b+F4/80+ tumor-associated macrophages (TAMs) as a key factor correlated with immune resistance. …

    Journal of Clinical Investigation 129(3), 1278-1294, 2019-03-01

    IR

  • Tumor budding and adjacent tissue at the invasive front correlate with delayed neck metastasis in clinical early-stage tongue squamous cell carcinoma

    Yamakawa Nobuhiro , Kirita Tadaaki , Umeda Masahiro , Yanamoto Souichi , Ota Yoshihide , Otsuru Mitsunobu , Okura Masaya , Kurita Hiroshi , Yamada Shin-ichi , Hasegawa Takumi , Aikawa Tomonao , Komori Takahide , Ueda Michihiro , Japan Oral Oncology Group (JOOG)

    Tumor budding is reportedly a promising prognostic marker in many cancers. … Moreover, the tissue surrounding a tumor is also considered to play a prognostic role. … In this study, we evaluated whether tumor budding and adjacent tissue at the invasive front can be potential novel predictors of DNM in early tongue cancer. … Methods In total, 337 patients with early-stage tongue squamous cell carcinoma were retrospectively reviewed. …

    Journal of Surgical Oncology 119(3), 370-378, 2019-03-01

    IR

  • A case of renal cell carcinoma in which long-term survival was obtained by simultaneous surgical resection of the primary tumor and maxillary gingival metastasis  [in Japanese]

    齋藤 大嗣 , 阿部 亮輔 , 樋野 雅文 , 八木 正篤 , 水城 春美 , 山田 浩之

    日本口腔外科学会雑誌 = Japanese journal of oral and maxillofacial surgery 65(3), 172-178, 2019-03

  • Detection of circulating tumor DNA for solid tumor and hematopoietic malignancy  [in Japanese]

    中村 誠二 , 加藤 菊也

    血液内科 = Hematology 78(3), 389-395, 2019-03

  • Chemotherapy for urologic neuroendocrine tumor  [in Japanese]

    岩本 大旭 , 泉 浩二 , 溝上 敦

    腫瘍内科 = Clinical oncology 23(3), 230-237, 2019-03

  • Serum level of soluble interleukin-2 receptor is positively correlated with metabolic tumor volume on F-18-FDG PET/CT in newly diagnosed patients with diffuse large B-cell lymphoma

    Senjo Hajime , Kanaya Minoru , Izumiyama Koh , Minauch Koichiro , Hirata Kenji , Mori Akio , Saito Makoto , Tanaka Masanori , Iijima Hiroaki , Tsukamoto Eriko , Itoh Kazuo , Ota Shuichi , Morioka Masanobu , Hashimoto Daigo , Teshima Takanori

    … Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin lymphoma. … High total metabolic tumor volume (TMTV) calculated using F-18-FDG PET/CT images at diagnosis predicts poor prognosis of patients with DLBCL. … Serum level of sIL-2R represents a convenient surrogate marker to estimate metabolic tumor burden measured by F-18-FDG PET/CT that can predict treatment outcomes of patients with DLBCL. …

    Cancer medicine 8(3), 953-962, 2019-03

    IR

  • Interleukin 1 upregulates microRNA-135b to promote inflammation-associated gastric carcinogenesis in mice.

    Tae Su Han , Voon Dominic Chih-Cheng , Oshima Hiroko , Nakayama Mizuho , Echizen Kanae , Sakai Eri , Yong Zachary Wei Ern , Murakami Kazuhiro , Yu Liang , Minamoto Toshinari , Ock Chan-Young , Jenkins Brendan J. , Kim Seong-Jin , Yang Han-Kwang , Oshima Masanobu

    … We investigated epithelial cell-specific changes in microRNA expression during gastric inflammation and gastritis-associated carcinogenesis in mice. … We measured expression of epithelial cell-enriched microRNAs and used bioinformatics analyses to integrate data from different systems to identify inflammation-associated microRNAs. …

    Gastroenterology 156(4), 1140-1155, 2019-03

    IR DOI

  • Plasma exosomal microRNA as a potential biomarker for glioblastoma multiform  [in Japanese]

    山口 響子 , 森口 徹生 , 山下 大介 , 大西 丘倫 , 金子 貞男 , 的場 亮 , 鄭 漢忠 , 近藤 亨

    最も悪性度の高い脳腫瘍の1つであるグリオブラストーマ(GBM)は,標準治療(外科手術および化学放射線療法)を施しても平均生存期間中間値(約15か月)が極めて短い難治性疾患である.この難治性の原因の1つは,腫瘍細胞の強い組織浸潤能と増殖能により神経症状発症時には摘出不可能な範囲に腫瘍細胞が拡散しているためである.つまり,簡便かつ検出感度の高いGBM診断用バイオマーカーがあれば,早期腫瘍摘出が可能とな …

    北海道歯学雑誌 39(2), 94-103, 2019-03

    IR

  • Immunolocalization of anti-Müllerian Hormone and Its Receptor in Granulosa Cell Tumors in Mares

    Munkhtuul Tsogtgerel , Murase Harutaka , Ball Barry Allen , Habukawa Kayo , Sato Fumio , Watanabe Kenichi , Nambo Yasuo

    … Granulosa cell tumor (GCT) is a sex-cord stromal tumor in mares and causes infertility. …

    Journal of Equine Veterinary Science (74), 9-12, 2019-03

    IR

  • A Case of Small Cell Carcinoma of the Renal Pelvis  [in Japanese]

    大森 千尋 , 百瀬 均 , 市川 和樹 , 初鹿野 俊輔 , 中濱 智則 , 松本 吉弘

    … The computed tomography and magnetic resonance imaging revealed a large invasive tumor in the right renal pelvis. … Histopathological examinations revealed a small cell carcinoma of the renal pelvis. … Primary small cell carcinoma of the renal pelvis is a rare disease. … To our knowledge, this is the 29th case of primary small cell carcinoma of the renal pelvis in the world literature. …

    泌尿器科紀要 = Acta urologica Japonica 65(2), 39-43, 2019-02-28

    IR DOI

  • A Case of Renal Cell Carcinoma Choroidal Metastasis Diagnosed from Vision Disorders  [in Japanese]

    今井 悠 , 松浦 泰史 , 久金 陽 , 森武 潤 , 坂東 重浩 , 山田 裕紀 , 清田 浩 , 飯田 貴絵 , 頴川 晋

    … A 69-year-old male with the complaint of a cough was referred to our hospital from a clinic where he was found to have simultaneous metastases of the left kidney tumor. … Renal cell carcinoma choroidal metastases are rare, but we need to consider them when the patient has vision disorders. …

    泌尿器科紀要 = Acta urologica Japonica 65(2), 33-37, 2019-02-28

    IR DOI

  • The Role of Tumor-Associated Neutrophils in Colorectal Cancer

    Mizuno Rei , Kawada Kenji , Itatani Yoshiro , Ogawa Ryotaro , Kiyasu Yoshiyuki , Sakai Yoshiharu

    … Normal host cells in the tumor microenvironment, such as macrophages and fibroblasts, have been reported to promote the growth of CRCs. … Although neutrophils were originally considered to have defensive functions against tumor cells, it has been revealed that some populations of neutrophils, called as tumor-associated neutrophils (TANs), have tumor-supportive functions. …

    International journal of molecular sciences 20(3), 2019-02-01

    IR

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