Search Results 1-20 of 65

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  • Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma

    Matsumoto Yuji , Ichikawa Tomotsugu , Kurozumi Kazuhiko , Otani Yoshihiro , Fujimura Atsushi , Fujii Kentaro , Tomita Yusuke , Hattori Yasuhiko , Uneda Atsuhito , Tsuboi Nobushige , Kaneda Keisuke , Makino Keigo , Date Isao

    … Glioblastoma (GBM) is characterized by extensive tumor cell invasion, angiogenesis, and proliferation. … Overexpression of ANXA2 in GBM cells increased the expression of OSMR and phosphorylated signal transducer and activator of transcription 3 (STAT3) and enhanced cell invasion, angiogenesis, proliferation, and mesenchymal transition. …

    Acta Neuropathologica Communications 8(1), 42, 2020-04-05


  • Dynamics of Minimal Residual Disease in Neuroblastoma Patients

    Uemura Suguru , Ishida Toshiaki , Thwin Khin Kyae Mon , Yamamoto Nobuyuki , Tamura Akihiro , Kishimoto Kenji , Hasegawa Daiichiro , Kosaka Yoshiyuki , Nino Nanako , Lin Kyaw San , Takafuji Satoru , Mori Takeshi , Iijima Kazumoto , Nishimura Noriyuki

    … Neuroblastoma is a common extracranial solid tumor of neural crest (NC) origin that accounts for up to 15% of all pediatric cancer deaths. … The disease arises from a transient population of NC cells that undergo an epithelial-mesenchymal transition (EMT) and generate diverse cell-types and tissues. …

    Frontiers in Oncology (9), 455, 2019-06-04


  • Plasma cell myeloma positive for t(14;20) with relapse in the central nervous system

    Murase Takayuki , Inagaki Atsushi , Masaki Ayako , Fujii Keiichiro , Narita Tomoko , Ri Masaki , Hanamura Ichiro , Iida Shinsuke , Inagaki Hiroshi

    … is a rare chromosomal abnormality in plasma cell myeloma (PCM), accounting for 1-2% of PCM cases. … The tumor responded well to a proteasome inhibitor, bortezomib, and the patient achieved complete remission. … Six months after remission, tumor relapse was noted in the left cerebellum and the right frontal lobe of the cerebrum. … After whole brain radiation therapy, the tumor masses decreased in size. …

    Journal of Clinical and Experimental Hematopathology 59(3), 135-139, 2019

    J-STAGE  Ichushi Web 

  • Wide Excision and Posterior Thigh Flap Reconstruction for Perianal Basal Cell Carcinoma  [in Japanese]

    Toyonaga Takayuki , Matsuda Hiromitsu , Mibu Ryuichi , Yamamoto Manabu , Tominaga Yohei , Yamamichi Kosaku , Tsuneyoshi Masazumi

    <p>基底細胞癌は顔面や頭頚部などの日光に当たる部分に好発するが肛門部には稀である.症例は83歳の男性で5年前からの肛門部の腫瘤と分泌物にて当院を受診した.初診時,肛門縁より1cm右外側に4cm大の腫瘤を認め,表面は潰瘍形成を伴っていた.肛門管超音波検査で4cmの低エコー腫瘤を認めたが,肛門管との連続や肛門括約筋への浸潤は認めなかった.MRI検査では肛門縁から右臀裂にかけて4cm大の分 …

    Nippon Daicho Komonbyo Gakkai Zasshi 72(4), 198-202, 2019

    J-STAGE  Ichushi Web 

  • Clinical significance of SUVmax on preoperative 18F-fluorodeoxyglucose positron emission tomography in patients who underwent R0-esophagectomy for esophageal cancer

    Shimizu Daisuke , Yuasa Norihiro , Miyake Hideo , Takeuchi Eiji , Miyata Kanji , Itoh Shigeki

    … The standardized uptake value (SUV) is a marker of tumor glucose metabolism, detected using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and may reflect tumor aggressiveness. … Histologically, cancers included squamous cell carcinomas, adenocarcinomas, and other tumors in 72, 3, and 11 patients, respectively. … The mean SUVmax was 8.9 ± 4.6, and SUVmax values significantly correlated with tumor invasion depth and stage. …

    Nagoya Journal of Medical Science 80(3), 401-409, 2018-08

    IR  DOI  Ichushi Web 

  • Critical role of the Ror-family of receptor tyrosine kinases in proliferation and invasion of malignant mesothelioma cells.

    Saji Takeshi , Nishita Michiru , Ogawa Hiroyuki , Doi Takefumi , Sakai Yasuhiro , Maniwa Yoshimasa , Minami Yasuhiro

    … Malignant pleural mesothelioma (MPM) is a highly aggressive tumor with poor prognosis and closely related to exposure to asbestos. … MPM is a heterogeneous tumor with three main histological subtypes, epithelioid, sarcomatoid, and biphasic types, among which sarcomatoid type shows the poorest prognosis. … The Ror‐family of receptor tyrosine kinases, Ror1 and Ror2, is expressed in various types of tumor cells at higher levels and affects their aggressiveness. …

    Genes to Cells 23(7), 606-613, 2018-07


  • Stem-like Human Breast Cancer Cells Initiate Vasculogenic Mimicry on Matrigel

    Izawa Yuki , Imanishi Moe , Onishi Momoka , Sakiyama Mayu , Inoue Sana , Takahashi Rei , Kashii-Magaribuchi Karin , Yoshida Kana , Nosaka Mayu , Tsuji Nanami , Yamamoto Ai , Kuroyanagi Kana , Tono Kanoko , Tanihata Misato

    … <p>Vasculogenic mimicry (VM), referring to vasculogenic structures lined by tumor cells, can be distinguished from angiogenesis, and is responsible for the aggressiveness and metastatic potential of tumors. … In fluorescence-activated cell sorting analysis, ALDH<sup>+</sup> …


    J-STAGE  Ichushi Web 

  • A Case of Pulmonary Pleomorphic Carcinoma Discovered During Optional Low-dose Computed Tomography Screening and Resected at the Early Stage

    Mino Nobuya , Yoshii Naoko , Okabe Hirofumi , Takahashi Seishiro , Ogawa Hiroshi , Tanahashi Masayuki , Niwa Hiroshi , Muto Shigeki

    … <p>  Pulmonary pleomorphic carcinoma (PPC) is a subgroup of non-small cell lung cancer that contains both epithelial and mesenchymal (sarcomatoid) components. … Because of its rarity and aggressiveness, there are few reports describing the early stage of PPC. … Microscopic images of the tumor showed both epithelial and sarcomatoid components. …

    Ningen Dock International 5(1), 38-43, 2018

    J-STAGE  Ichushi Web 

  • Establishment of a Patient-Derived Tumor Xenograft Model and Application for Precision Cancer Medicine

    Okada Seiji , Vaeteewoottacharn Kulthida , Kariya Ryusho

    … PDXs are now in the spotlight as more accurate human cancer models compared with mouse tumor and human cancer cell lines transplanted into mice. … Xenograft efficiency differs by type of tumor, site of implantation, and tumor aggressiveness. …

    Chemical and Pharmaceutical Bulletin 66(3), 225-230, 2018

    J-STAGE  Ichushi Web 

  • Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells

    Gunarta I Ketut , Li Rong , Nakazato Ryota , Suzuki Ryusuke , Boldbaatar Jambaldorj , Suzuki Takeshi , Yoshioka Katsuji

    … This aggressiveness appears to be due to the cancer cells' ability to reversibly switch between phenotypes with non-invasive and invasive potential, and microphthalmia-associated transcription factor (MITF) is known to play a central role in this process. … Gli1 knockdown (KD) melanoma cell lines, established by using Gli1-targeting lentiviral short hairpin RNA, exhibited a markedly reduced invasion ability, but their MITF expression and activity were the same as controls. …

    Cancer Science 108(8), 1602-1611, 2017-08-01

    IR  Ichushi Web 

  • Green Tea Polyphenol Induces Changes in Cancer-Related Factors in an Animal Model of Bladder Cancer

    Matsuo Tomohiro , Miyata Yasuyoshi , Asai Akihiro , Sagara Yuji , Furusato Bungo , Fukuoka Junya , Sakai Hideki

    … Green tea polyphenol (GTP) suppresses carcinogenesis and aggressiveness in many types of malignancies including bladder cancer. … Tumor cell proliferation and microvessel density were evaluated along with immunohistochemical analysis of human antigen (Hu)R, vascular endothelial growth factor (VEGF)-A, cyclooxygenase (COX)-2, and hemeoxygenase (HO)-1 expression. …

    PLOS ONE 12(1), e0171091, 2017-01-31


  • Comparison of gene expression profiles of gingival carcinoma Ca9-22 cells and colorectal adenocarcinoma HT-29 cells to identify potentially important mediators of SLPI-induced cell migration

    Takamura Tsuyoshi , Suguro Hisashi , Mikami Yoshikazu , Iwase Takashi , Komiyama Yusuke , Kuyama Kayo , Komiyama Kazuo , Oki Hiderou

    … <p>Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor whose expression level is positively correlated with tumor aggressiveness and metastatic potential. … The malignancy of cancer cells is highly dependent on cell migration activity. …

    Journal of Oral Science 59(2), 279-287, 2017


  • Regorafenib induces adaptive resistance of colorectal cancer cells via inhibition of vascular endothelial growth factor receptor

    Tomida Chisato , Nagano Hikaru , Yamagishi Naoko , Uchida Takayuki , Ohno Ayako , Hirasaka Katsuya , Nikawa Takeshi , Teshima-Kondo Shigetada

    … <p>Recently, inhibition of tumor angiogenesis has become an important anti-cancer therapy. … Tumor angiogenesis is regulated by multiple signaling pathways, including VEGF and VEGF receptor (VEGF-R), FGF and FGF receptor (FGF-R), and PDGF and PDGF receptor (PDGF-R) pathways. … In addition to endothelial cells, cancer cells express the three receptors, suggesting that the antiangiogenic inhibitors affect tumor cells. …

    The Journal of Medical Investigation 64(3.4), 262-265, 2017

    IR  J-STAGE  Ichushi Web 

  • Comparableroles of CD44v8–10 and CD44s in the developmentof bone metastases in a mouse model.


    … However, ESRP1 did not significantly affect cell proliferation, migration, invasion or tumor sphere formation in vitro. … The overexpression of CD44v8-10 in MCF-7 human breast cancer cells, which rarely express any isoform of CD44, promoted cell migration and sphere formation, whereas the overexpression of CD44v8-10 in MDA-MB-231 cells, which endogenously express high levels of CD44s, did not exert these effects. …

    Oncology letters 12(4), 2962-2969, 2016-08-10


  • Pheochromocytoma multisystem crisis treated with emergency surgery: a case report and literature review

    Kakoki Katsura , Miyata Yasuyoshi , Shida Youhei , Hakariya Tomoaki , Takehara Kosuke , Izumida Seiya , Sekino Motohiro , Kinoshita Naoe , Igawa Tsukasa , Fukuoka Junya , Sakai Hideki

    … Background: Pheochromocytoma is a neuroendocrine tumor that predominantly presents with hypertension, palpitations, and tachycardia due to excessive catecholamine excretion. … From the resected specimen, his tumor was judged as pheochromocytoma. … The benign pheochromocytoma also presented with high cell proliferation potential, which may be a cause of the extreme aggressiveness of PMC. …

    BMC Research Notes (8), 758, 2015-12-09


  • The status of donor cancer tissues affects the fate of patient-derived colorectal cancer xenografts in NOG mice

    FUJII Etsuko , KATO Atsuhiko , CHEN Yu Jau , MATSUBARA Koichi , OHNISHI Yasuyuki , SUZUKI Masami

    … Next we analyzed the tumor aggressiveness in terms of histology grade of the original tumor and found that they were related to engraftment. … Detailed histopathological examination of the transplanted tissues strongly indicated that lymphocytes engrafted with the tumor cells affect engraftment. …

    Experimental Animals 64(2), 181-190, 2015

    J-STAGE  Ichushi Web 

  • High expression of Twist is associated with tumor aggressiveness and poor prognosis in patients with renal cell carcinoma

    Ohba Kojiro , Miyata Yasuyoshi , Matsuo Tomohiro , Asai Akihiro , Mitsunari Kensuke , Shida Yohei , Kanda Shigeru , Sakai Hideki

    … Aims: Twist has been reported to play crucial roles for malignant aggressiveness; … however, detailed pathological significance of Twist in renal cell carcinoma (RCC) is not fully understood. … Cell proliferation, angiogenesis, and apoptosis were measured as the percentage of Ki-67-positive cells (proliferation index, PI), CD31-stained vessels (microvessel density, MVD), and TUNEL-positive cells (apoptotic index, AI). …

    International journal of clinical and experimental pathology 7(6), 3158-3165, 2014-05


  • Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue

    Ishikawa Kazuya , Yagi-Nakanishi Sayaka , Nakanishi Yosuke , Kondo Satoru , Tsuji Akira , Endo Kazuhira , Wakisaka Naohiro , Murono Shigeyuki , Yoshizaki Tomokazu

    … Objective: The aim of this study was to clarify the role of IL-33 in tumor progression. … Methods: Surgical specimens from 81 patients with squamous cell carcinoma of the tongue were studied using immunohistochemistry. … Primary tumor sections were analyzed for IL-33 and ST2 expression. … To examine the influence of IL-33 on the microenvironment of the tumor, we determined the mast cell density (MCD) and microvessel density of the stroma. …

    Auris Nasus Larynx 41(6), 552-557, 2014-01-01

    IR  Ichushi Web 

  • Tumor associated macrophage expressing CD204 is associated with aggressiveness of esophageal squamous cell carcinoma  [in Japanese]

    Urakawa Naoki , Nishio Mari , Takase Nobuhisa , Shigeoka Manabu , Watajima Taketo , Utunomiya =Soken , Koma Yuichiro , Semba Shyuho , Yokozaki Hiroshi

    Japan Journal of Molecular Tumor Marker Research 29(0), 30-31, 2014

    J-STAGE  Ichushi Web 

  • DF3 epitope expression on MUC1 mucin is associated with tumor aggressiveness, subsequent lymph node metastasis, and poor prognosis in oral squamous cell carcinoma  [in Japanese]

    HAMADA Tomofumi , NOMURA Masahiro , KAMIKAWA Yoshiaki , SUGIHARA Kazumasa

    … However, to the best of the authors' knowledge, the relation between DF3/MUC1 expression and outcomes has not been investigated in patients with oral squamous cell carcinoma (OSCC). …

    Japanese Journal of Oral and Maxillofacial Surgery 60(4), 162-176, 2014


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