Search Results 1-20 of 440

  • Common cytokine polymorphisms and predisposition to polycystic ovary syndrome: a meta-analysis

    Zhang Yunli , Che Lina , Zhang Mingyan , He Jiaoyan

    … –51 C/T polymorphisms might influence susceptibility to PCOS in the overall pooled population. … –51 C/T polymorphisms might influence susceptibility to PCOS in Asians, whereas <i>IL-6</i> … –889 C/T polymorphisms might influence susceptibility to PCOS in Caucasians.</p> …

    Endocrine Journal 67(5), 561-567, 2020

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  • <i>CD44</i> Genotypes Are Associated with Susceptibility and Tumor Characteristics in Colorectal Cancer Patients

    Márquez-González Rosa María , Saucedo-Sariñana Anilú Margarita , Barros-Núñez Patricio , Gallegos-Arreola Martha Patricia , Pineda-Razo Tomás Daniel , Marin-Contreras María Eugenia , Flores-Martínez Silvia Esperanza , Sánchez-Corona José , Rosales-Reynoso Mónica Alejandra

    … After adjusting for age and gender, these same genotypes and the G/G genotype of the rs7116432 polymorphism were associated with TNM stage and tumor location in the colon. … variants are involved with risk, TNM stage and tumor location in colorectal cancer.</p> …

    The Tohoku Journal of Experimental Medicine 250(2), 109-119, 2020

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  • Release of urinary aquaporin-2-bearing extracellular vesicles is decreased in pregnant Japanese Black cattle

    SINLAPADEELERDKUL Thitaporn , SONODA Hiroko , UCHIDA Kazuyuki , KITAHARA Go , IKEDA Masahiro

    … Similarly, the levels of EV marker proteins in uEVs, including tumor susceptibility gene 101 (TSG101) protein and apoptosis-linked gene 2-interacting protein X (ALIX), were significantly decreased during gestation. …

    Journal of Veterinary Medical Science 81(11), 1609-1615, 2019

    J-STAGE  Ichushi Web 

  • A Case of Enzootic Bovine Leukosis in a Five-month-old Calf  [in Japanese]

    WAKATSUKI Takuji , SUGIYAMA Sadamu , TAKAOKA Asako , HASHIDA Akihiko , MIZUKAMI Chiaki , HIROSE Yuri , KADOTA Koichi , TAKESHIMA Shinnosuke , AIDA Yoko

    … Histologically, tumor cells characterized by pleomorphism and atypia showed proliferation or infiltration in lymph nodes and a variety of internal organs. … B cell clonality tests showed biclonality growth of tumor cells. … Analysis of bovine leukocyte antigen (BoLA) genes, associated with the susceptibility to BLV, showed <i>BoLA-DRB3<i></i></i><sup>*</sup><i>1101</i> …

    Journal of the Japan Veterinary Medical Association 72(10), 608-613, 2019

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  • Genetic Polymorphisms in <i>APC, DVL2</i>, and <i>AXIN1 </i>Are Associated with Susceptibility, Advanced TNM Stage or Tumor Location in Colorectal Cancer

    Rosales-Reynoso Mónica Alejandra , Flores-Martínez Silvia Esperanza , Sánchez-Corona José , Saucedo-Sariñana Anilú Margarita , Contreras-Díaz Karla Berenice , Márquez-González Rosa María , Barros-Núñez Patricio , Pineda-Razo Tomás Daniel , Marin-Contreras María Eugenia , Durán-Anguiano Óscar , Gallegos-Arreola Martha Patricia

    … Increased susceptibility to CRC was associated with the polymorphic variants rs11954856 (<i>APC</i>), rs222836 (<i>DVL2</i>), and rs9921222 (<i>AXIN1</i>). … Decreased susceptibility was associated with the polymorphisms rs459552 (<i>APC</i>) and 2074222 (<i>DVL2</i>). … Association was also observed with advanced Tumor-Node-Metastasis (TNM) stages and tumor location. …

    The Tohoku Journal of Experimental Medicine 249(3), 173-183, 2019

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  • Comparison of biological features between severely immuno-deficient NOD/Shi-<i>scid Il2rg<sup>null</sup></i> and NOD/LtSz-<i>scid Il2rg<sup>null</sup></i> mice

    Nagatani Mariko , Tamura Kazutoshi , Kasahara Kenichiro , Kodera Tsutomu , Suzuki Daisuke , Igura Saori , Fukunaga Yachiyo , Kanemitsu Hiroyuki , Nakamura Daichi , Mochizuki Masahiro , Kemi Masayuki

    … <p>Biological background data up to 11 weeks of age and tumorigenic susceptibility to xenotransplantation with HeLa cells were compared between severely immuno-deficient NOG and NSG mice. … To evaluate tumorigenic susceptibility to xenotransplantation, female mice were implanted in the dorsal subcutis with 1×10<sup>3</sup> …

    Experimental Animals 68(4), 471-482, 2019

    J-STAGE  Ichushi Web 

  • Correlation and Characteristics of Intravoxel Incoherent Motion and Arterial Spin Labeling Techniques Versus Multiple Parameters Obtained on Dynamic Susceptibility Contrast Perfusion MRI for Brain Tumors

    Dolgorsuren Enkh-Amgalan , Harada Masafumi , Kanazawa Yuki , Abe Takashi , Otomo Maki , Matsumoto Yuki , Mizobuchi Yoshifumi , Nakajima Kohhei

    … <p>Purpose : To compare data on brain tumors derived from intravoxel incoherent motion (IVIM) and arterial spin labeling (ASL) imaging with multiple parameters obtained on dynamic susceptibility contrast (DSC) perfusion MRI and to clarify the characteristics of IVIM and ASL perfusion data from the viewpoint of cerebral blood flow (CBF) analysis. …

    The Journal of Medical Investigation 66(3.4), 308-313, 2019

    J-STAGE  Ichushi Web 

  • Tumor Necrosis Factor-α Gene Polymorphism (G-308A) and Dilated Cardiomyopathy

    Chen Min , Jiang Yu-Feng , Yang Hua-Jia , Zhang Nan-Nan , Rui Qing , Zhou Ya-Feng

    … <p>The issue that genetic polymorphism of tumor necrosis factor-α (TNF-α) is associated with dilated cardiomyopathy (DCM) is debatable. … We sought to investigate the potential role of TNF-α gene polymorphism (G-308A) in the susceptibility to dilated cardiomyopathy.</p><p>We retrieved PubMed, EMBASE, and CNKI to collect all articles which reported on the association between TNF-α G-308A polymorphism and dilated cardiomyopathy. …

    International Heart Journal 60(3), 656-664, 2019

    J-STAGE  Ichushi Web 

  • Association between Tumor Necrosis Factor-<i>α</i> Promoter -308 G/A Polymorphism and Early Onset Sepsis in Preterm Infants

    Varljen Tatjana , Rakic Olgica , Sekulovic Gordana , Jekic Biljana , Maksimovic Nela , Janevski Milica Rankovic , Novakovic Ivana , Damnjanovic Tatjana

    … Genetic predisposition may have an impact on EOS susceptibility and outcome. … gene polymorphism and the susceptibility and outcome of EOS in preterm infants. …

    The Tohoku Journal of Experimental Medicine 247(4), 259-264, 2019

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  • Differentiating between Glioblastoma and Primary CNS Lymphoma Using Combined Whole-tumor Histogram Analysis of the Normalized Cerebral Blood Volume and the Apparent Diffusion Coefficient

    Bao Shixing , Watanabe Yoshiyuki , Takahashi Hiroto , Tanaka Hisashi , Arisawa Atsuko , Matsuo Chisato , Wu Rongli , Fujimoto Yasunori , Tomiyama Noriyuki

    … This study aimed to determine whether whole-tumor histogram analysis of normalized cerebral blood volume (nCBV) and apparent diffusion coefficient (ADC) for contrast-enhancing lesions can be used to differentiate between glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL).</p><p>Methods: From 20 patients, 9 with PCNSL and 11 with GBM without any hemorrhagic lesions, underwent MRI, including diffusion-weighted imaging and dynamic susceptibility contrast perfusion-weighted imaging before …

    Magnetic Resonance in Medical Sciences 18(1), 53-61, 2019

    J-STAGE  Ichushi Web 

  • Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice

    Abe Tomoyuki , Tanaka Yuka , Piao Jinlian , Tanimine Naoki , Oue Naohide , Hinoi Takao , Verjan Garcia Noel , Miyasaka Masayuki , Matozaki Takashi , Yasui Wataru , Ohdan Hideki

    … Results: Systemic anti-SIRPα mAb administration significantly increased Hepa1-6 and CMT93 cell susceptibility to macrophage phagocytosis, both in vitro and in vivo. … Anti‐SIRPα mAb treatment inhibited tumor progression in CPC‐APC mice and significantly improved overall survival. … In contrast, anti‐SIRPα mAb exhibited enhanced macrophage phagocytic activity and marked anti-tumor effects against gastroenterological malignancies. …

    Annals of Gastroenterological Surgery 2(6), 451-462, 2018-11

    IR  Ichushi Web 

  • Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia

    Shiozawa Yusuke , Malcovati Luca , Gallì Anna , Sato-Otsubo Aiko , Kataoka Keisuke , Sato Yusuke , Watatani Yosaku , Suzuki Hiromichi , Yoshizato Tetsuichi , Yoshida Kenichi , Sanada Masashi , Makishima Hideki , Shiraishi Yuichi , Chiba Kenichi , Hellström-Lindberg Eva , Miyano Satoru , Ogawa Seishi , Cazzola Mario

    … Here we report transcriptomic analyses of 265 bone marrow samples from myelodysplasia patients, followed by a validation using CRISPR/Cas9-mediated gene editing and an assessment of nonsense-mediated decay susceptibility. … Target genes include tumor suppressors and genes of mitochondrial iron metabolism or heme biosynthesis. …

    Nature Communications (9), 2018-09-07

    IR 

  • Zebrafish-Based Drug Discovery and Precision Medicine

    Tanaka Toshio , Kuriyama Naohisa , Sasagawa Shota , Kitahara Erina , Okuno Mayuko , Koiwa Junko , Takahashi Yuka , Sugimura Aiko , Mikami Ikuko , Isaji Shuji

    … </p><p>The pancreatic cancer is a solid tumor with high mortality and the therapeutic response is very low with the poor clinical prognosis and omics-based personalized medical treatment aren't achieved.</p><p>A quantitative in vivo imaging of zebrafish system was developed originally as a new clinical cancer xenotransplantation model. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO4-10-25, 2018

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  • Development of Next Generation Sequencing panel including cancer risk gene and drug-metabolizing enzymes

    Nguyen Phuong T. T , Jeong Hye-Eun , Kim Ho-Sook , Ghim Jong-Lyul , Shin Jae Gook

    … <p>BACKGROUND: Somatic and hereditary germline mutations to increase the susceptibility to cancers have increased risk for developing cancer. … </p><p>RESULTS: Validation revealed sensitivity and specificity of 100% for detection of mutations compared with conventional Sanger sequencing and TruSight® Tumor 15 panel. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO4-10-18, 2018

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  • Establishment and Characterization of Novel Leukemic Cell Lines Resistant to New-Generation Dihydrofolate Reductase Inhibitor, Pralatrexate

    Oiwa Kana , Hosono Naoko , Nishi Rie , Ueda Takanori , Yamauchi Takahiro

    … Pralatrexate (PDX) is a novel dihydrofolate reductase inhibitor with greater affinity for reduced folate carrier (RFC1) and folypolyglutamate synthetase than methotrexate (MTX), resulting in greater internalization and accumulation in tumor cells. … These cell lines were't induced apoptosis by PDX, but showed high susceptibility to nucleoside analogs. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-8-43, 2018

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  • Inhibition of the HDAC6/Sp1 pathway by azaindolylsulfonamide reduces cancer stemness and restores treatment susceptibility in glioblastoma

    Chuang Jian-Ying , Hsu Che-Chia , Chang Kwang-Yu , Chang Wen-Chang

    … <p>Glioblastoma (GBM), known as a highly aggressive brain tumor, has extremely poor prognosis and high mortality even following standard treatment with surgery, radiotherapy, and chemotherapy using the first-line agent temozolomide (TMZ). … Treatment resistance and recurrence are the most known challenges in tumor therapies, and that have an association with an abundant source of cancer stem-like cells (CSCs). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-8-7, 2018

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  • Primary immunodeficiencies and hematological malignancies  [in Japanese]

    KANEGANE Hirokazu , HOSHINO Akihiro , TAKAGI Masatoshi

    … Various mechanisms contribute to increased tumor susceptibility in patients with PIDs, which are as follows: defective cell-mediated tumor surveillance, defective apoptosis, specific susceptibility to carcinogens, decreased pathogen clearance and over-active inflammatory responses, defects in cytokinesis, impaired control of virus-infected cells, defects in cell cycle control, and impaired cellular response to genotoxic agents. …

    Rinsho Ketsueki 59(11), 2459-2467, 2018

    J-STAGE  Ichushi Web 

  • Pulmonary tuberculosis following anti-tumor necrosis factor-α therapy in Crohn's disease:a case report  [in Japanese]

    HARA Yusuke , HIBI Toshifumi , KOBAYASHI Taku , OKABAYASHI Shinji , NAKANO Masaru , SAGAMI Shintaro , OZAKI Ryo , NAKAYAMA Sohei , SUZUKI Yusuke , TSUNEMATSU Satoshi

    … <p>Anti-tumor necrosis factor-α (TNF-α) is a principal treatment for Crohn's disease (CD). … However, it increases the susceptibility to tuberculosis (TB) infection, and therefore, screening examination prior to treatment initiation is crucial. …

    Nippon Shokakibyo Gakkai Zasshi 115(11), 996-1003, 2018

    J-STAGE  Ichushi Web 

  • Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells

    Sakaizawa Takao , Taniguchi Shun'ichiro , Matsumura Tomio , Fujii Chifumi , Hida Shigeaki , Toishi Masayuki , Shiina Takayuki , Yoshida Kazuo , Hamanaka Kazutoshi , Ito Ken-ichi

    … Importantly, ASC expression is decreased in lung cancer and various cancers, but its precise function in tumor progression remains unknown. … Thus, ASC may be involved in tumor suppression and cell death via Bcl-2 and pSrc. …

    The Tohoku Journal of Experimental Medicine 244(2), 133-144, 2018

    J-STAGE  Ichushi Web 

  • Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways

    Shimazu Kengo , Tada Yuji , Morinaga Takao , Shingyoji Masato , Sekine Ikuo , Shimada Hideaki , Hiroshima Kenzo , Namiki Takao , Tatsumi Koichiro , Tagawa Masatoshi , 関根 郁夫

    … We then examined anti-tumor effects of metformin, an agent for type 2 diabetes, and combinatory effects of metformin and nutlin-3a, an inhibitor for ubiquitin-mediated p53 degradation, on human mesothelioma.MethodsWe examined the effects with a colorimetric assay and cell cycle analyses, and investigated molecular events in cells treated with metformin and/or nutlin-3a with Western blot analyses. …

    BMC Cancer (17), 309, 2017-05

    IR 

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