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  • Functional Pleiotropy of Organic Anion Transporting Polypeptide OATP2B1 Due to Multiple Binding Sites

    SHIRASAKA Yoshiyuki , MORI Takanori , SHICHIRI Megumi , NAKANISHI Takeo , TAMAI Ikumi

    … 273 fmol/min/oocyte for high- and low-affinity sites, respectively. … Contribution analysis revealed that transport of estrone-3-sulfate mediated by high- and low-affinity sites on OATP2B1 could be evaluated at the concentrations of 0.005 and 50 µM, respectively. … pH-dependence study of OATP2B1-mediated estrone-3-sulfate uptake suggested that high- and low-affinity sites show different pH sensitivity. …

    Drug Metabolism and Pharmacokinetics 27(3), 360-364, 2012


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