タンパク質結晶学と構造生物学 周辺科学との協調とその将来 医薬品開発とタンパク質結晶学

  • 栗原 宏之
    山之内製薬株式会社分子化学研究所分子設計研究室

書誌事項

タイトル別名
  • Protein Crystallography and Structural Biology. Cooperation with Relarted Sciences and Future Plans. Drug Discovery based on Protein Crystallography.
  • イヤクヒン カイハツ ト タンパクシツ ケッショウガク

この論文をさがす

抄録

Protein crystallograpy is now a central tool in the drug design process. Using this technique, we can determine atomic resolution structutres for many physiologically important proteins, both in their native state and in complex with a ligand. These data can assist both lead discovery and lead optimization, but at the current time most successful examples have involved the latter, Specific knowledge of the binding site obtained from these structures, enhances the lead optimization process by reducing the number of compounds to be tested. This paper describes the various technologies which are required to make a rational approach successful.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (26)*注記

もっと見る

詳細情報

問題の指摘

ページトップへ