Delay of Hair Regrowth in Mice as a Possible Biological Dosimeter on the Skin in Case of Over Exposure.

• 別所 遊子

  福井医科大学医学部看護学科地域看護学講座

• 草間 朋子

  大分県立看護科学大学

抄録

The delay of hair regrowth of mice after irradiation was examined to investigate its possibility as a biological dosimeter in the cases of localized over exposure. Hairs on the dorsal skin of mice were shaved and irradiated with a ⁹⁰Sr/⁹⁰Y β-ray source in early anagen or midanagen stage of hair cycle. Skin doses were 0.5-10Gy and 1-4Gy, respectively. Hair regrowth was observed with a scaling loupe. Hair regrowth delay was dose dependent, fitting the linear-quadratic function and the linear function according to the stages of hair. Histological observations indicated that the hair matrix cells death was the main cause of hair regrowth delay in the midanagen stage. Dose estimation functions, derived from the dose-effect relationship curves, could be applied for the dosimetey of the skin over exposure. It could detect a dose over 1Gy, and as early as a few days after the exposure.

収録刊行物

• 保健物理

  保健物理 33 (4), 395-399, 1998

  日本保健物理学会

キーワード

• biological dosimeter
• skin
• hair regrowth delay
• hair matrix cells
• pycnotic index
• mitotic index
• epilation

詳細情報

• CRID: 1390282679267182080
• NII論文ID: 10002137449
• NII書誌ID: AN00228458
• DOI: 10.5453/jhps.33.395
• COI: 1:CAS:528:DyaK1MXktVWrtQ%3D%3D
• ISSN: 18847560
• ISSN: 03676110
• NDL書誌ID: 108451
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I108451
• Web Site: https://search.jamas.or.jp/link/ui/1999131567
• 本文言語コード: en
• データソース種別:
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  • NDL
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• 抄録ライセンスフラグ: 使用不可