Inhibition of Sardine Flesh Lipoxygenase by a New Antioxidant from Aspergillus terreus.

• ISHIKAWA Yukihiro

  College of Education, Tottori University

• ITO Tadayoshi

  Institute for Fermentation, Osaka

• LEE Kuo Hsiung

  School of Pharmacy, University of North Carolina at Chapel Hill

Bibliographic Information

Other Title

• <I>Aspergillus terreus</I>の生産する新規酸化防止剤とそのイワシ肉リポキシゲナーゼ阻害活性
• Inhibition of Sardine Flesh Lipoxygenas

Abstract

A new antioxidant and potent lipoxygenase (LOX) inhibitor, NC3B, was isolated from the fungus Aspergillus terreus and identified as 1, 3-dihydro-7-methyl-4, 5, 6-trihydroxy-isobenzofuran. Under weight gain method conditions with methyl linoleate as a substrate, NC3B was a stronger antioxidant than tocopherol (Toc) and acted as a weak Toc synergist during the autoxidation of methyl linoleate. NC3B significantly inhibited the oxidation of linoleic acid by sardine flesh LOX and caused reduction in oxygen uptake by the substrate.

Journal

• Journal of Japan Oil Chemists' Society

  Journal of Japan Oil Chemists' Society 45 (12), 1321-1325, 1996

  Japan Oil Chemists' Society

Keywords

• antioxidant
• lipoxygenase inhibitor
• Aspergillus
• microorganism

Details

• CRID: 1390001204091560192
• NII Article ID: 10002271467
• NII Book ID: AN10512582
• DOI: 10.5650/jos1996.45.1321
• ISSN: 18841996
• ISSN: 13418327
• NDL BIB ID: 4106761
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4106761
• Web Site: https://www.jstage.jst.go.jp/article/jos1996/45/12/45_12_1321/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed