Effects of Diacylglycerols on Lipid Metabolism in Human.

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  • ヒトの脂質代謝に及ぼすジアシルグリセリンの影響
  • ヒト ノ シシツ タイシャ ニ オヨボス ジアシルグリセリン ノ エイキョウ

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Abstract

Examination was made of the effects of dietary diacylglycerols (DG) on changes in reconstituted triacylglycerol (TG) concentrations and other biochemical data regarding various lipid metabolites. Seventeen healthy subjects after fasting for 11 h were each administered a single doses of lipids, as DG-and TG-emulsions, at a dosage of 44 g lipid per 60 kg body weight. The amount of TG in the serum increased for 4 h following the administration and then at 8 h, the initial value was resumed. Serum TG at 6 h and 8 h after administration of DG significantly decreased compared with that after the administration of TG. The suppressive effect of DG on residual reconstituted TG in the serum was clearly observed in subjects with higher initial TG. For subjects showing this supressive effect, apolipoprotein C II which activates lipoprotein lipase of adipose tissue involved in chylomicron and VLDL, significantly decreased after DG administration. 3-Hydroxybutyric acid produced by the β-oxidation of fatty acids increased in the serum after the administration of DG. DG would thus appear to be an ideal source of energy, assuring less fat accumulation compared to TG.

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