Effects of Lysophospholipids on Hyaluronic Acid Synthesis in the Skin.III. The in vivo Study in Hairless-mice.

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  • リゾリン脂質による皮膚のヒアルロン酸産生促進効果（第３報）　ヘアレスマウスを用いたｉｎ　ｖｉｖｏ系による検討
  • リゾ リン シシツ ニヨル ヒフ ノ ヒアルロンサン サンセイ ソクシン コウ
  • The <I>in vivo</I> Study in Hairless-mice
  • ヘアレスマウスを用いた<I>in vivo</I>系による検討

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Abstract

Certain lysophospholipids were previously shown to enhance hyaluronic acid production in confluent culture of normal human dermal fibroblasts. In the present study, hairless mice were given hypodermic injection of lysophospholipid derived from soy bean (Soy LPL) or lauloyl lysophosphatidylcholine (lauroly LPC). Hyaluronic acid production was noted to significantly increased at either 2800μg/mL Soy LPL or 13203080 μg/mL lauloyl LPC. These values were 10 times the effective concentration in vitro. Two weeks of prolonged administration of Soy LPL increased hyaluronic acid content in the skin, but the control level was resumed 4 weeks following injection. A living body would thus appear to naturally resist stimulation of lysophospholipid. After one hypodermic injection of 2200μg/mL lauloyl LPC, always noted to be an effective concentration, hyaluronic acid content in the skin was measured. At 24 h, this content had increased and at 48 h, the control level was noted. Lauloyl LPC would thus appear effective in early stages and its effect not to persist for a prolonged time. Abnormal skin appearance following hypodermic injection or prolonged lysophospholipid administratoin was not recognized. Lysophospholipids should thus prove effective as cutaneous moisturizing agants.

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