Computation Transport Phenomena in Chemical Engineering. Studies of Refining Crystallization on Octotiamine.

• Yoshino Toshitaka

  Manufacturing Technology Laboratories Fujisawa Pharmaceutical Co., Ltd.

• Momonaga Masashi

  Manufacturing Technology Laboratories Fujisawa Pharmaceutical Co., Ltd.

• Shinozaki Katsuhiko

  Manufacturing Technology Laboratories Fujisawa Pharmaceutical Co., Ltd.

• Yazawa Hisatoyo

  Manufacturing Technology Laboratories Fujisawa Pharmaceutical Co., Ltd.

Bibliographic Information

Other Title

• 流れの数値解析と化学装置のモデリング　　オクトチアミンの精製晶析に関する研究
• オクトチアミン ノ セイセイ ショウセキ ニカンスルケンキュウ

Abstract

Most medical supplies which are obtained as purified crystals are produced in the form of tablets mixed with additives before dosing. The most important property for such medical supplies is to control the elution rate of tablets appropriately. The elution rate changes according to the internal structure, crystal size, affinity with additives and other factors. To develop such a complex, compound tablet, crystallization of Octotiamine was carried out and the crystallization method and conditions that produced the optimum tablet are established. Furthermore, we examin scale-up factors for this crystallization process.

Journal

• KAGAKU KOGAKU RONBUNSHU

  KAGAKU KOGAKU RONBUNSHU 23 (6), 906-913, 1997

  The Society of Chemical Engineers, Japan

Keywords

• Crystallization
• Mixing
• Scale-Up
• Drug Manufacturing
• Tabletizing

Details

• CRID: 1390282679484849152
• NII Article ID: 10002768466
• NII Book ID: AN00037234
• DOI: 10.1252/kakoronbunshu.23.906
• ISSN: 13499203
• ISSN: 0386216X
• NDL BIB ID: 4334865
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4334865
• Web Site: http://www.jstage.jst.go.jp/article/kakoronbunshu1975/23/6/23_6_906/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed