Elimination of Background and Kidney Depth Correction during Renal Uptake Rate Measurement with 99mTc-Dimercaptosuccinic Acid Using a Kinetic Modeling Approach.

• MURASE Kenya

  Department of Radiology, Ehime University School of Medicine

• TANADA Shuji

  Department of Radiology, Ehime University School of Medicine

• HAMAMOTO Ken

  Department of Radiology, Ehime University School of Medicine

Bibliographic Information

Other Title

• 動態モデルを用いた<SUP>99m</SUP>Tc-ジメルカプトコハク酸による腎摂取率測定におけるバックグラウンドと腎深さ補正の省略
• Elimination of Background and Kidney De

Abstract

Renal uptake rate measurement with ^99mTc-dimercaptosuccinic acid (DMSA) requires accurate background and kidney depth correction as well as several hours for the examination. We developed a new method which required no correction and only 20 min for examination using the kinetic modeling approach. Our model consists of three compartments with the rate constants for the transport of DMSA from blood to renal tissue (k₁), from tissue to blood (k₂), and DMSA uptake in the tissue (k₃) . In addition, we introduced a parameter indicating the blood pool fraction, rather than correcting for background. The parameters were calculated by fitting the model equation to the time-activity curve obtained by injection of 148 MBq of DMSA and sequential imaging for 20 min. The net uptake rate of DMSA by tubular cells (K) was also calculated from K=k₁×k₃/ (k₂+k₃) . The K values obtained without background and kidney depth correction were well correlated with the renal uptake rates measured two hours after DMSA administration (r=0.918, n=120), and with those obtained using background correction (r=0.989) or correction for attenuation due to kidney depth (r=0.982) . Our results indicate that this is a promising method of quantifying renal cortical function, as it requires no correction and only 20 min for image acquisition.

Journal

• RADIOISOTOPES

  RADIOISOTOPES 45 (8), 491-499, 1996

  Japan Radioisotope Association

Keywords

• renal uptake rate
• technetium-99m dimercaptosuccinic acid
• kinetic model approach
• background
• kidney depth correction

Details

• CRID: 1390001204153337984
• NII Article ID: 130004382937
• NII Article ID: 10003720162
• NII Book ID: AN00351589
• DOI: 10.3769/radioisotopes.45.491
• ISSN: 18844111
• ISSN: 00338303
• NDL BIB ID: 4019516
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4019516
• Web Site: http://www.jstage.jst.go.jp/article/radioisotopes1952/45/8/45_8_491/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997021251
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed