Organ Distribution of 137Cs in Mouse Fetuses and Their Dams.

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  • MATSUSAKA Naonori
    Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • YAMAKAWA Yoji
    Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • SATO Itaru
    Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • TSUDA Shuji
    Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • KOBAYASHI Haruo
    Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • NISHIMURA Yoshikazu
    National Institute of Radiological Sciences

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Other Title
  • マウス胎子および母体における<SUP>137</SUP>Csの臓器分布
  • Organ Distribution of 137Cs in Mouse Fe

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Abstract

A single dose of 137Cs was given intravenously to pregnant mice on day 17 of gestation, and organ distribution of this nuclide in mouse fetsuses and their dams was studied by measuring radioactivity and by macroautoradiography. Fetal uptake of 137Cs was 0.8% of the initial dose 24 h after administration ; about 11% of the initial dose was incorporated in litter during the same period. Concentrations of 137Cs in fetal organs were 0.4-0.8%/g 24 h after administration, whereas concentrations in dams' organs were in a range of 2-6%/g. Therefore, concentrations in maternal organs such as liver, spleen, kidneys and muscle were 4-6 times higher than those in fetuses. Among the maternal organs, the salivary gland represented the highest concentration of 25%/g 1 h after administration to 6.4%/g 24 h after administration. This remarkable uptake in the salivary gland should be emphasized because of its close location to the thyroid gland in experimental animals and humans. Macroautoradiograms supported the findings obtained by measuring radioactivity in the organs. Macroautoradiograms in color may facilitate visual understanding of organ distribution of this nuclide.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 46 (4), 214-218, 1997

    Japan Radioisotope Association

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