Regio-and Stereoselective Incorporation of a ^<13>C Nuclide into D-ribo-Phytosphingosine via SmI_2-Mediated C-C Formation with ^<13>C-Labeled Isocyanide

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著者

    • MURAKAMI Masahiro
    • Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University
    • ITO Hajime
    • Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University
    • ITO Yoshihiko
    • Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University

抄録

Preparation of a <SUP>13</SUP><I>C</I>-labeled isocyanide and its application to the total synthesis of [2-<SUP>13</SUP><I>C</I>]<FONT SIZE=-2>D</FONT>-<I>ribo</I>-C<SUB>18</SUB>-phytosphingosine are described. The synthesis of the labeled phytosphingosine is based on the use of the isocyanide as a <SUP>13</SUP>CH–NH<SUB>2</SUB> precursor in the SmI<SUB>2</SUB>-mediated three-component coupling reaction, wherein regio- and stereoselective incorporation of a <SUP>13</SUP><I>C</I> nuclide in the carbon skeleton is achieved.

収録刊行物

  • Chemistry letters

    Chemistry letters 1996(3), 185-186, 1996-03-05

    The Chemical Society of Japan

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各種コード

  • NII論文ID(NAID)
    10003738929
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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