Average time until fixation of mutants with compensatory fitness interaction

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We consider two loci (or DNA sites) in which mutation occurs from the wild-type allele <i>A</i><sub>1</sub> (resp. <i>B</i><sub>1</sub> to a mutant allele <i>A</i><sub>2</sub> (resp. <i>B</i> <sub>2</sub>) in the first (resp. second) locus. Gene combinations or haplotypes with a single mutation, <i>A</i><sub>1</sub><i>B</i><sub>2</sub> or <i>A</i><sub>2</sub><i>B</i><sub>1</sub> are deleterious. The double mutant, however, does not have the harmful effect of the single mutations. This model is a two-locus two-allele model with compensatory fitness interaction. With this model and a finite population, the average time until fixation of the double mutant, <i>A</i><sub>2</sub><i>B</i> <sub>2</sub>, starting from the state in which the population consists exclusively of <i>A</i><sub>1</sub><i>B</i><sub>1</sub> is calculated. We show that linkage between the loci is an important factor in the average time until fixation and that compensatory fitness interaction can be a mechanism for molecular evolution when linkage between the loci is not weak. Deleterious mutation can accelerate the speed of fixation of a double mutant. An interpretation of this phenomenon is presented.<br>

収録刊行物

  • Genes & genetic systems

    Genes & genetic systems 71(3), 167-173, 1996-06

    The Genetics Society of Japan

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各種コード

  • NII論文ID(NAID)
    10003759845
  • NII書誌ID(NCID)
    AA11077421
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13417568
  • NDL 記事登録ID
    4163718
  • NDL 雑誌分類
    ZR1(科学技術--生物学)
  • NDL 請求記号
    Z53-W539
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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