hiiragi, a gene essential for wing development in Drosophila melanogaster, affects the Notch cascade

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A recessive mutation, <i>hiiragi</i><sup>P1</sup>, on the second chromosome of <i>Drosophila</i> was obtained by <i>P</i> element insertion mutagenesis. Flies homozygous for <i>hiiragi</i><sup>P1</sup> have notched wing margins. Genetic interactions between <i>hiiragi</i> and the genes that encode components of Notch signaling, such as <i>Notch, Hairless, Serrate</i> and <i>deltex</i>, strongly support the involvement of <i>hiiragi</i> in the signal transduction cascade of Notch. It has been reported that Serrate and Delta, other components of Notch signaling, share EGF-like repeats and a second conserved cysteine-rich motif, and that these components interact physically with the same region of Notch. In <i>hiiragi</i><sup>P1</sup><i>; Serrate</i> <sup>D</sup>/+ double mutants, we observed synergistic enhancement of the notched phenotype of wing margins. In contrast, <i>Delta</i> <sup>FX3</sup> had no phenotypic effect on <i>hiiragi</i><sup>P1</sup> in <i>hiiragi</i><sup>P1</sup><i>; Delta</i><sup>FX3</sup>/+ double mutants. Taken together, these results indicate that <i>hiiragi</i> is involved in the Notch signaling cascade induced by <i>Serrate</i> rather than by <i>Delta</i>.<br>

収録刊行物

  • Genes & genetic systems

    Genes & genetic systems 71(4), 247-254, 1996-08

    The Genetics Society of Japan

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各種コード

  • NII論文ID(NAID)
    10003760092
  • NII書誌ID(NCID)
    AA11077421
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13417568
  • NDL 記事登録ID
    4163729
  • NDL 雑誌分類
    ZR1(科学技術--生物学)
  • NDL 請求記号
    Z53-W539
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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