The euryarchaeotes, a subdomain of Archaea, survive on a single DNA polymerase : Fact or farce?

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Archaea is now recognized as the third domain of life. Since their discovery, much effort has been directed towards understanding the molecular biology and biochemistry of Archaea. The objective is to comprehend the complete structure and the depth of the phylogenetic tree of life. DNA replication is one of the most important events in living organisms and DNA polymerase is the key enzyme in the molecular machinery which drives the process. All archaeal DNA polymerases were thought to belong to family B. This was because all of the products of <i>pol </i>genes that had been cloned showed amino acid sequence similarities to those of this family, which includes three eukaryal DNA replicases and <i>Escherichia coli</i> DNA polymerase II. Recently, we found a new heterodimeric DNA polymerase from the hyperthermophilic archaeon, <i>Pyrococcus furiosus</i>. The genes coding for the subunits of this DNA polymerase are conserved in the euryarchaeotes whose genomes have been completely sequenced. The biochemical characteristics of the novel DNA polymerase family suggest that its members play an important role in DNA replication within euryarchaeal cells. We review here our current knowledge on DNA polymerases in Archaea with emphasis on the novel DNA polymerase discovered in Euryarchaeota.<br>

収録刊行物

  • Genes & genetic systems

    Genes & genetic systems 73(6), 323-336, 1998-12-01

    The Genetics Society of Japan

参考文献:  73件中 1-73件 を表示

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各種コード

  • NII論文ID(NAID)
    10003763202
  • NII書誌ID(NCID)
    AA11077421
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    13417568
  • NDL 記事登録ID
    4681886
  • NDL 雑誌分類
    ZR1(科学技術--生物学)
  • NDL 請求記号
    Z53-W539
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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