Characterization by Western Blotting of Mouse Intestinal Glycoproteins Bound by Escherichia coli Heat-Labile Enterotoxin Type I

• SHIDA Kan

  Yakult Central Institute for Microbiological Research

• TAKAMIZAWA Kotaro

  Yakult Central Institute for Microbiological Research

• TAKEDA Tae

  Department of Infectious Diseases Research, National Children's Medical Research Center

• OSAWA Toshiaki

  Yakult Central Institute for Microbiological Research

抄録

Escherichia coli heat-labile enterotoxin type I (LT-I)-binding galactoproteins, which were not recognized by cholera toxin, were detected in intestinal epithelial cells of BALB/c mouse by Western blotting. Inhibitory studies using lectins and modifications of sugar chain suggest that LT-I recognizes certain mucin-type sugar chains containing the terminal Galβ1-3GalNAc sugar sequence in the galactoproteins. The terminal sugar sequence is identical to that of GM1 ganglioside, the well-documented functional receptor for LT-I.

収録刊行物

• Microbiology and immunology

  Microbiology and immunology 40 (1), 71-75, 1996-01-20

  財団法人 学会誌刊行センター

キーワード

• Escherichia coli heat-labile enterotoxin (LT)
• Galactoprotein
• Receptor

詳細情報

• CRID: 1571980074132170112
• NII論文ID: 10004786919
• NII書誌ID: AA00738350
• ISSN: 03855600
• Web Site: http://chemport.cas.org/cgi-bin/sdcgi?APP=ftslink&action=reflink&origin=jstage2&version=1.0&coi=1:CAS:528:DyaK28XhsVGntro%3D&md5=e4beac8c00f234c3546d3eeb8f0cd578
• Web Site: https://search.jamas.or.jp/link/ui/1996143773
• 本文言語コード: en
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