Human Recombinant Activin Induces Proliferation of Spermatogonia in vitro in the Japanese Eel Anguilla japonica

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  • Miura Takeshi
    Department of Biology, Faculty of Fisheries, Hokkaido University
  • Miura Chiemi
    Department of Biology, Faculty of Fisheries, Hokkaido University
  • Yamauchi Kohei
    Department of Biology, Faculty of Fisheries, Hokkaido University
  • Nagahama Yoshitaka
    Laboratory of Reproductive Biology, Department of Developmental Biology, National Institute for Basic Bilolty

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タイトル別名
  • Human Recombinant Activin Induces Proliferation of Spermatogonia <i>in vitro</i> in the Japanese Eel <i>Anguilla japonica</i>
  • Human Recombinant Activin Induces Proli

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Activin, a member of the transforming growth factor-β superfamily, has recentlybeen isolated from eel testicular cDNA library. Using an in vitro testicular organ culture system, we investigated the effect of human recombinant activin A and B in eel spermatogenesis. Addition of human recombinant activin A and B (10 ng and 100 ng/ml) to the culture medium induced proliferation of spermatogonia within 15 days in the same manner as addition of 11-ketotestosterone (10 ng/ml) for positive control. In cultured testes without activins, however, the proliferation of spermatogoniawas not observed. Although it is necessary to investigate the eel's own activin A and B protein, these results suggest the possibility that activin induces initiation of spermatogenesis in Japanese eel.

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