Pharmacokinetics of Oxytetracycline in Rainbow Trout Oncorhynchus mykiss Following Bolus Intravenous Administration

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  • Uno Kazuaki
    Department of Food Science, Konan Women's College Kazuaki Uno, Konan Women's College
  • Aoki Takahiko
    Faculty of Bioresources, Mie University
  • Ueno Ryuji
    Faculty of Bioresources, Mie University
  • Maeda Iwao
    Department of Food Science, Konan Women's College

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タイトル別名
  • Pharmacokinetics of Oxytetracycline in Rainbow Trout <i>Oncorhynchus mykiss</i> Following Bolus Intravenous Administration
  • Pharmacokinetics of Oxytetracycline in

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The present study examined the pharmacokinetics of oxytetracycline in rainbow trout Oncorhynchus mykiss. The pharmacokinetics of oxytetracycline were determined after intravenous administration (50mg/kg body weight). Serum concentrations of oxytetracycline were determined using high performance liquid chromatography with direct injection. Serum levels could be fitted to a two-compartment model. The calculated half-lives for the distribution phase (T1/2α) and the elimination phase (T1/2α) were 0.5 and 52h, respectively. The apparent volume of distribution (Vdβ) and total body clearance (ClB) were calculated to be 1.46 l/kg and 19.6ml/kg/h, respectively. The area under the serum concentration-time curve was 2554 μg•h/ml. Serum protein binding in vivo of oxytetracycline was 51.1±7.4%. As an application of this pharmacokinetic study, the oral bioavailability and the dosage regimens of oxytetracycline in rainbow trout were briefly evaluated.

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