Identification of the structural gene encoding the SH-activated hemolysin of Listeria monocytogenes: listeriolysin O is homologous to streptolysin O and pneumolysin
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- J Mengaud
- Unité de Génie Microbiologique, Institut Pasteur, Paris, France.
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- J Chenevert
- Unité de Génie Microbiologique, Institut Pasteur, Paris, France.
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- C Geoffroy
- Unité de Génie Microbiologique, Institut Pasteur, Paris, France.
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- J L Gaillard
- Unité de Génie Microbiologique, Institut Pasteur, Paris, France.
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- P Cossart
- Unité de Génie Microbiologique, Institut Pasteur, Paris, France.
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<jats:p>By immunoblotting with an antiserum raised against purified listeriolysin O, we have detected the presence of a truncated protein of 52 kilodaltons in culture supernatants of a Tn1545-induced nonhemolytic mutant of Listeria monocytogenes (J.L. Gaillard, P. Berche, and P. Sansonetti, Infect. Immun. 52:50-55, 1986). The region of insertion of the transposon has been cloned and sequenced. The transposon had inserted in an open reading frame the listeriolysin O gene. The deduced amino acid sequence of this open reading frame revealed that listeriolysin O is homologous to streptolysin O and pneumolysin, although homologies were not detectable at the DNA level.</jats:p>
収録刊行物
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- Infection and Immunity
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Infection and Immunity 55 (12), 3225-3227, 1987-12
American Society for Microbiology
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詳細情報
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- CRID
- 1361137046349914496
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- NII論文ID
- 10004890663
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- NII書誌ID
- AA00673732
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- ISSN
- 10985522
- 00199567
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