Reduced Anti-Pseudomonas aeruginosa Activity of a Cephalosporin, Cefodizime, in Rats Whose Neutrophils Were Selectively Depleted by a Monoclonal Antibody

• ARAKI Akemi

  Department of Immunology and Parasitology, Yamagata University School of Medicine

• SENDO Fujiro

  Department of Immunology and Parasitology, Yamagata University School of Medicine

抄録

In order to clarify the mechanisms of the in vivo antibacterial activity of a cephalosporin, cefodizime (CDZM), the effect of this antibiotic on Pseudomonas aeruginosa E7 infection was examined in rats whose neutrophils had been selectively depleted by monoclonal antibody RP-3. CDZM was less effective in RP-3-treated rats than in untreated rats. However, treatment of rats with recombinant human granulocyte-colony stimulating factor (rhG-CSF) augmented the in vivo activity of this antibiotic. Furthermore, the in vivo antibacterial activity of two other cephalosporins, cefpimizole (CPIZ) and cefoperazone (CPZ), was bilaterally affected by a rise or fall in the neutrophil number, although to a lesser degree than was the case with CDZM. Taken together, neutrophils play an important role in the in vivo antibacterial activity of certain cephalosporins.

収録刊行物

• Microbiology and immunology

  Microbiology and immunology 40 (5), 333-338, 1996-05-20

  財団法人 学会誌刊行センター

キーワード

• Neutrophil
• Antibiotics
• Pseudomonas aeruginosa
• Cefodizime

詳細情報

• CRID: 1573387449068689792
• NII論文ID: 10004892711
• NII書誌ID: AA00738350
• ISSN: 03855600
• Web Site: http://chemport.cas.org/cgi-bin/sdcgi?APP=ftslink&action=reflink&origin=jstage2&version=1.0&coi=1:CAS:528:DyaK28XjslGktr8%3D&md5=175b07b93786315124b60f21eb1f4370
• Web Site: https://search.jamas.or.jp/link/ui/1996209772
• 本文言語コード: en
• データソース種別:
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