Hepatitis C Virus Infection-Associated Markers in Sera from Blood Donors in Surabaya, Indonesia
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- DARMADI Siswanto
- Tropical Disease Research Center, Airlangga University
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- SOETJIPTO
- Tropical Disease Research Center, Airlangga University
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- HANDAJANI Retno
- Tropical Disease Research Center, Airlangga University
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- LUSIDA Maria Inge
- Tropical Disease Research Center, Airlangga University
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- SOEMARTO
- Tropical Disease Research Center, Airlangga University
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- SAKUGAWA Hiroshi
- First Department of Internal Medicine, School of Medicine, University of the Ryukyus
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- ISHIDO Satoshi
- Department of Microbiology, Kobe University School of Medicine
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- HOTTA Hak
- Department of Microbiology, Kobe University School of Medicine
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Abstract
Among 2, 233 sera obtained from volunteer blood donors, 259 (11.6%) showed elevated alanine aminotransferase (ALT) levels. A second-generation enzyme-linked immunosorbent assay (ELISA) revealed that 23 (8.9%) of the 259 sera were positive for antibodies against hepatitis C virus (HCV), whereas only 9 (1.4%) of 646 sera randomly collected from blood donors with normal ALT levels were positive (P<0.001). The overall prevalence of anti-HCV antibodies among blood donors was estimated to be 2.3%. HCV RNA was detected in 19 (83%) of the 23 anti-HCV-positive sera with elevated ALT levels, and 8 (89%) of the 9 sera with normal ALT levels. Among the anti-HCV-positive sera, IgM anti-HCV was detected in 5 (22%) of 23 sera with elevated ALT levels and in 2 (22%) of 9 sera with normal ALT levels. All of the IgM anti-HCV-positive sera were positive for HCV RNA, irrespective of ALT levels.
Journal
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 40 (5), 401-405, 1996-05-20
Center For Academic Publications Japan
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Keywords
Details 詳細情報について
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- CRID
- 1572261549161790720
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- NII Article ID
- 10004892960
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- NII Book ID
- AA00738350
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- ISSN
- 03855600
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- Text Lang
- en
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- Data Source
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- CiNii Articles