Kinetics of Organ-Associated Natural Killer Cells and Intermediate CD3 Cells during Pulmonary and Hepatic Granulomatous Inflammation Induced by Mycobacterial Cord Factor

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  • TABATA Akihiro
    Department of Bacteriology, Osaka City Unviersity Medical School
  • KANEDA Kenji
    Department of Anatomy, Osaka City Unviersity Medical School
  • WATANABE Hisami
    Department of Immunology, Niigata University School of Medicine
  • ABO Toru
    Department of Immunology, Niigata University School of Medicine
  • YANO Ikuya
    Department of Bacteriology, Osaka City Unviersity Medical School

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Abstract

We investigated here the kinetics of natural killer (NK) cells and extrathymic T cells, which include intermediate CD3 cells and γδ T cells, in the cord factor-induced granulomatous inflammation of the lungs and liver. In Balb/c mice, pulmonary inflammation elevated the proportion of NK cells and that of extrathymic T cells to mononuclear cells in the lungs. C3H/He mice exhibited shorter-term inflammation of the lungs than Balb/c mice and accordingly showed a smaller increase in the proportions of pulmonary NK cells and intermediate CD3 cells. In the liver of Balb/c mice, hepatic NK cells increased as well with the granulomatous changes, while intermediate CD3 cells exhibited a transient decrease before they increased. The present study has demonstrated that granulomatous inflammation is accompanied by the increase of lung-associated NK cells and extrathymic T cells and that there exists a difference between these two mouse strains in the induction of these lymphocyte subsets by cord factor.

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