Genomic Structures and Characterization of Rael Family Members Encoding GPI-Anchored Cell Surface Proteins and Expressed Predominantly in Embryonic Mouse Brain

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  • Nomura Midori
    Department of Medical Genetics, Division of Molecular Biomedicine, Research Institute for Microbial Diseases, Osaka University
  • Zou Zhihua
    Department of Medical Genetics, Division of Molecular Biomedicine, Research Institute for Microbial Diseases, Osaka University
  • Joh Tadashi
    Department of Medical Genetics, Division of Molecular Biomedicine, Research Institute for Microbial Diseases, Osaka University
  • Takihara Yoshihiro
    Department of Medical Genetics, Division of Molecular Biomedicine, Research Institute for Microbial Diseases, Osaka University
  • Matsuda Yoichi
    Laboratory of Animal Genetics, School of Agricultural Sciences, Nagoya University
  • Shimada Kazunori
    Department of Medical Genetics, Division of Molecular Biomedicine, Research Institute for Microbial Diseases, Osaka University

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タイトル別名
  • Genomic Structures and Characterization of Rae1 Family Members Encoding GPI-Anchored Cell Surface Proteins and Expressed Predominantly in Embryonic Mouse Brain.
  • Genomic Structures and Characterization

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Raelα, Raelβ, and Raelγ cDNAs isolated from retinoic acid-treated mouse embryonal carcinoma F9 cells encode cell surface proteins sharing partial homology with MHC class I molecules, and mRNAs corresponding to these cDNAs were detected exclusively in early mouse embryos, especially in the head region. To initiate studies on their roles, the rae1α gene and the genomic DNAs covering the complete coding regions of the rae1β and rae1γ genes were isolated and their structures were analyzed. Although the coding regions of the three rae1 genes were highly homologous, the restriction map of the 5'-end region of the rae1α gene differed from that of the rae1β and rae1γ genes. The rae1 family members were mapped by FISH on mouse chromosome 10A4 region. Genomic DNAs hybridizable with a Rae1 cDNA were not detected in rat and human. Rae1 genes were preferentially expressed in early mouse embryos, preferentially in the brain, and RAE1 proteins were anchored on the cell surface by a glycosyl phosphatidylinositol (GPI)-tail, a feature shared by important cell surface ligands.

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