新キノロン薬grepafloxacinの動物感染モデルにおける投与法の検討

• 戸塚 恭一

  東京女子医科大学内科・臨床中央検査部

• 柴田 雄介

  東京女子医科大学内科・臨床中央検査部

• 菊池 賢

  東京女子医科大学内科・臨床中央検査部

• 長谷川 裕美

  東京女子医科大学内科・臨床中央検査部

• 清水 喜八郎

  東京女子医科大学内科・臨床中央検査部

書誌事項

タイトル別名

• Administration method of a new quinolone antibiotic, grepafloxacin, in an animal infection model

抄録

The administration method of a new quinolone antibiotic, grepafloxacin (GPFX), was examined in a neutropenic mouse thigh-infection model. As compared with ofloxacin (OFLX), GPFX showed a stronger antibacterial effect and longer effective regrowth time against Staphylococcus aureus infections. The antibacterial effect of OFLX on Klebsiella pneumoniae was superior to that of GPFX, but regrowth was soon observed due to its short half-life (T_1/2). GPFX, in spite of differences in administration times, did not cause an extremely increased or decreased number of bacteria, and showed a slightly better result after 24 hours than OFLX. Concerning its pharmacokinetics in mice, GPFX had a lower Cmax and longer T_1/2 in plasma than OFLX. In addition, GPFX showed less AUC in plasma but almost equal AUC in muscle tissues as compared with OFLX. These results indicate that GPFX has a long T_1/2 in plasma and excellent penetration into tissue.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 43 (Supplement1), 244-248, 1995

  公益社団法人 日本化学療法学会

キーワード

• grepafloxacin
• PAE
• ERT

詳細情報

• CRID: 1390282681260834432
• NII論文ID: 10005466100
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.43.supplement1_244
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/1996000988
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可