婦人科領域におけるpazufloxacinの基礎的・臨床的検討

• 長 南薫

  昭和大学藤が丘病院産婦人科

• 宮川 善二郎

  昭和大学藤が丘病院産婦人科

• 清水 篤

  昭和大学藤が丘病院産婦人科

• 野嶽 幸正

  昭和大学藤が丘病院産婦人科

• 国井 勝昭

  国井産婦人科病院

書誌事項

タイトル別名

• Tissue penetration and clinical evaluation of pazufloxacin in obstetrics and gynecology

抄録

A newly developed synthetic quinolone derivative antibacterial agent, pazufloxacin (PZFX), was investigated for its tissue penetration and clinical efficacy against obstetric and gynecological infections, and the following results were obtained.<BR>1. Tissue penetration: Penetration of the drug into genital organ tissues was found to be good, the level in uterine arterial serum being 0.06-2.05μg/ml and that in tissues being 0.04-2.28μg/g after oral administration of 200mg.<BR>2. Clinical results: PZFX was given to 24 patients with obstetric and gynecological infections. The clinical efficacy was evaluable in 22 patients at a daily dose of 200-600mg for 3-10 days, and a clinical efficacy rate of 95.5% (21/22) and bacteriological response of 94.1% (16/17) were obtained. Side effect was not observed but one case of stomach discomfort.<BR>From these findings, we consider PZFX to be a useful antibacterial agent in obstetrics and gynecology.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 43 (Supplement2), 443-449, 1995

  公益社団法人 日本化学療法学会

キーワード

• PZFX
• 産婦人科領域
• 組織内濃度
• 臨床効果

詳細情報

• CRID: 1390001206287025152
• NII論文ID: 10005466949
• NII論文ID: 130004297267
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.43.supplement2_443
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/1996058656
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可