新penem薬ritipenem (ritipenem acoxilの活性本体) の痙攣誘発作用とGABA受容体結合に及ぼす影響

• 堀 誠治

  聖マリアンナ医科大学難病治療研究センター

• 嶋田 甚五郎

  聖マリアンナ医科大学難病治療研究センター

書誌事項

タイトル別名

• Convulsant activity of ritipenem (an active form of ritipenem acoxil) and its effect on GABA receptor binding

抄録

Since β-lactams have been reported to induce convulsions, we studied the convulsant activity of ritipenem (RIPM), an active form of ritipenem acoxil (RIPM-AC), and its effect on the receptor binding of γ-aminobutyric acid (GABA), an inhibitory transmitter in the central nervous system. Intraventricular injection of imipenem (IPM), cefazolin (CEZ) and cephaloridine (CER) induced convulsions in mice in a dose-dependent manner, whereas RIPM did not induce convulsion up to 200 nmol/brain. These β-lactams inhibited GABA receptor binding in a concentration-dependent manner. The order of inhibitory activity was IPM>CEZ>CER≥RIPM. These in vivo and in vitro results suggest that RIPM might have weaker convulsant activity than IPM, CEZ and CER.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 43 (Supplement3), 81-84, 1995

  公益社団法人 日本化学療法学会

キーワード

• penem薬
• GABA受容体
• 痙攣

詳細情報

• CRID: 1390001206286288768
• NII論文ID: 10005467319
• NII論文ID: 130004297420
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.43.supplement3_81
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/1996047759
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可