慢性気道感染症に対するｇｒｅｐａｆｌｏｘａｃｉｎとｏｆｌｏｘａｃｉｎの二重盲検比較試験

• 小林 宏行他

  杏林大学第一内科

書誌事項

タイトル別名

• Double-blind study on grepafloxacin in chronic respiratory tract infection.

抄録

The clinical efficacy, safety, and usefulness of a new quinolone antibacterial agent, greparfloxacin (GPFX), in the treatment of chronic respiratory tract infections were evaluated in a double-blind study using ofloxacin (OFLX) as the control drug. GPFX and OFLX were administered by the oral route in a daily dose of 300mg q. d. and 200mg t. i. d., respectively, for 14 successive days, in principle.<BR>1. The clinical efficacy rates of GPFX and OFLX in the 190 efficacy-evaluable patients among the 203 patients enrolled in the study were 90.3%(84/93) and 90.7%(88/97), respectively. The difference was not statistically significant, between the two groups, and the 90% confidence interval was-7.3% to 6.5%, demonstrating the clinical equivalency of both drugs.<BR>2. The bacterial eradication rate was 72.9%(35/48) in the GPFX group, and 84.2%(32/38) in the OFLX group. The difference in rates between the two groups was not significant.<BR>3. Adverse reactions were observed in 8.3%(8/96) of the patients in the GPFX group and 4.1%(4/98) of the patients in the OFLX group. Abnormal clinical laboratory values were observed in 12.2%(11/90) of the patients in the GPFX group and 6.7%(6/89) of the patients in the OFLX group. There were no significant differences in the occurrence of adverse reactions in the two groups. The safety rate was 79.3%(73/92) in the GPFX group and 88.8%(79/89) in the OFLX group. The rates were not significantly different.<BR>4. The usefulness rate was 86.8%(79/91) in the GPFX group and 87.5%(77/88) in the OFLX group. The difference between the two groups was not statistically significant and the 90% confidence interval of-9.0% to 7.6% demonstrated the clinical equivalency of both drugs.<BR>The above results demonstrated that GPFX 300mg q. d. is equivalent in clinical usefulness to OFLX 200mg t. i. d. in the treatment of chronic respiratory tract infections.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 45 (6), 463-483, 1997

  公益社団法人 日本化学療法学会

キーワード

• OPC-17116
• 慢性気道感染症
• 二重盲検比較試験

詳細情報

• CRID: 1390282681262576384
• NII論文ID: 130004297823
• NII論文ID: 10005469733
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.45.463
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/1997236212
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可