書誌事項
- タイトル別名
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- Bacteriological study of indirect pathogenicity in pediatric patients with upper respiratory tract bacterial infection.
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Organisms isolated from rhinopharyngeal fluid obtained from pediatric patients with upper respiratory tract bacterial infection were examined for β-lactamase production and susceptibility of anti-microbial drugs to estimate the direct pathogen as well as the β-lactamase-producing indirect pathogen, and to consider the preferable first choice antimicrobial drugs for the treatment of these patients. The predominant organisms which were estimated as the direct pathogen were Streptococcus pneumoniae and Haemophilus influenzae; 29.5% of the S. pneumoniae were penicillin-intermediate S. pneumoniae and penicillin-resistant S. pneumoniae, and 13.8% of the H. influenzae were β-lactamase-producing strains. The main organisms which were estimated as the indirect pathogen were Moraxella subgenus Branhamella catarrhalis and Staphylococcus aureus which produced β-lactamase. These organisms were often isolated concomitantly with S. pneumoniae or H. influenzae. The predominant patterns of isolated bacteria were S. pneumoniae plus M.(B.) catarrhalis and H. influenzae plus M.(B.) catarrhalis, these two patterns accounted for 32.6% of all patients. Thus it is suggested that the main indirect pathogenic factor in pediatric patients with upper respiratory tract bacterial infection is β-lactamase which is produced by M.(B.) catarrhalis. In the patients in whom an indirect pathogen is involved, the rate of elimination of S. pneumoniae and H. influenzae was significantly higher in those treated with clavulanic acid/amoxicillin than in those treated with amoxicillin.
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 46 (4), 139-147, 1998
公益社団法人 日本化学療法学会
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詳細情報
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- CRID
- 1390001206284879744
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- NII論文ID
- 130004297857
- 10005470189
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可