種々の臨床分離株の各種抗菌薬に対する感受性サーベイランス　その１　　１９９６年度分離グラム陽性球菌について

• 木村 美司

  塩野義製薬株式会社創薬研究所

• 吉田 勇

  塩野義製薬株式会社創薬研究所

• 東山 伊佐夫

  塩野義製薬株式会社創薬研究所

• 長野 馨

  塩野義製薬株式会社医薬開発部

• 佐々木 緊

  塩野義製薬株式会社創薬研究所

書誌事項

タイトル別名

• Surveillance of susceptibility of clinical isolates of various bacterial species to antibacterial agents. No. 1. Against Gram-positive cocci isolated in 1996.
• No.1 against Gram-positive cocci isolated in 1996
• その1 1996年度分離グラム陽性球菌について

抄録

We used agar-dilution MIC determinations to assess the activity of 41 antibacterial agents against various clinical isolates (19 Gram-positive cocci, 920 strains), which were isolated in 1996 at 16 facilities in Japan, and compared the results with those of similar studies in 1992 and 1994. We found that 60.4% of the strains of Staphylococcus aureus were methicillin-resistant S. aureus (MRSA). This high level frequency was equivalent to those found in 1992 and 1994. Vancomycin (VCM), arbekacin (ABK) and sulfamethoxazole-trimethoprim (ST) proved to have the highest antibacterial activity against these MRSA with an MIC₉₀ of less than 1.56μg/ml. The agants which showed higher antibacterial activity against Staphylococcus epidermidis were VCM, ABK and minocyclin (MIC₉₀≤1.56μg/ml). Most of the agants tested, includingβ-lactam antibiotics, demonstrated good antibacterial activity against Streptococcus pyogenes and Satreptococcus agalactiae. The rate of penicillin-resistant Streptococcus pneumoniae (PRSP) was 38.6%, which was equivalent to those rates reported in 1992 and 1994. We noted that carbapenems, VCM, cefpirome, cefditoren and cefcapene displayed a high level of antibacterial activity against PRSP (MIC₉₀≤0.39μg/ml). Also the agents which showed higher antibacterial activity against Enterococcus faecalis were ampicillin, ST, VCM and imipenem (MIC₉₀≤3.13μg/ml), while VCM proved to have the highest antibacterial activity against Enterococcus faecium with an MIC⁹⁰ of 0.78μg/ml. Finally, we found no strain highly resistant to VCM among any of the isolates of Gram-positive cocci tested including MRSA and Enterococcus species.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 46 (9), 324-342, 1998

  公益社団法人 日本化学療法学会

キーワード

• 臨床分離株
• 抗菌薬
• 感受性サーベイランス
• グラム陽性球菌

詳細情報

• CRID: 1390282681263874176
• NII論文ID: 130004297874
• NII論文ID: 10005470607
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.46.324
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/1999050004
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可