Klinefelter's Syndrome Accompanied by Mixed Connective Tissue Disease and Diabetes Mellitus

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Author(s)

Abstract

We report a rare case of Klinefelter's syndrome (KS) with mixed connective tissue disease (MCTD), diabetes mellitus (DM) and several endocrine disorders. A 57-year-old man presented with polyarthritis and tapering fingers with Raynaud's phenomenon on admission. In addition to a karyotype of 47, XXY, a marked restrictive change in respiratory functional test, a myogenic pattern in electromyogram, the positive tests for anti-RNP antibody indicated that this was a case of KS complicated with MCTD. The patients also presented DM with insulin resistance, hyperprolactinemia, slight primary hypothyroidism and hypoadrenocorticism. The mechanism for these coincidences remains to be elucidated.<br>(Internal Medicine 38: 875-881, 1999)

Journal

  • Internal Medicine

    Internal Medicine 38(11), 875-881, 1999-11

    The Japanese Society of Internal Medicine

References:  20

Codes

  • NII Article ID (NAID)
    10005530846
  • NII NACSIS-CAT ID (NCID)
    AA10827774
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    09182918
  • NDL Article ID
    4904458
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z53-M398
  • Data Source
    CJP  NDL  J-STAGE 
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