WHHLウサギにおよぼすコレステノン(cholest-4-en-3-one)の抗高脂血症作用について

J-STAGE 被引用文献1件 参考文献9件

書誌事項

タイトル別名
  • Antihyperlipidemic Effect of Cholest-4-en-3-one on WHHL Rabbits

この論文をさがす

抄録

Antihyperlipidemic effect of cholestenone (cholest-4-en-3-one), an intestinal catabolite of cholesterol, was investigated by 1% dietary exposure in three Watanabe heritable hyperlipidemic (WHHL) rabbits which are models of familial hypercholesterolemia. Animals were fed standard chow diet for 2 weeks, 1% cholestenonesupplemented diet for 3 weeks, followed by a standard chow diet for 2 weeks. When animals were fed the cholestenone-supplemented diet, serum cholesterol levels decreased progressively from about 700 to about 470 mg/dl during the 3 weeks, and serum triglyceride levels dropped rapidly from about 360 to about 50mg/dl by 1 week. The reduced levels of serum triglyceride were maintained for the next 2 week. After cessation of cholestenone, the amounts of serum cholesterol in 2 animals and triglyceride in all animals rose progressively to the previous levels. There were few differences in phospholipids levels in the serum of animals fed cholestenone. Body weight gain, food consumption and food efficiency of animals were inhibited by dietary exposure to this chemical. There were no obvious abnormalities due to consumption of cholestenone on clinical observation.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (9)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ