腎不全患者における糖化アルブミン測定の有用性

DOI 被引用文献5件 参考文献10件

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タイトル別名
  • Glycated Albumin as a Useful Glycemic Indicator in Diabetic Patients with End-stage Renal Disease.

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Measurement of levels of HbA1c and glycated proteins, such as glycated albumin (GA) and fructosamine, is the most reliable method of assessing long-term glycemic control in diabetic patients. However, little is known about GA in patients with associated uremia. In order to clarify the effects of impaired renal function on GA levels, we measured blood glucose, HbA1c, GA, serum albumin and blood urea nitrogen in patients with and without chronic renal failure (CRF). Each group was divided into normal glucose tolerance, borderline glucose tolerance and diabetic subgroups. There was no difference in GA levels between those with and without CRF in either the normal or the borderline glucose tolerance groups. HbA1c levels in the CRF group were significantly lower in the patients taking erythropoietin than in the patients not taking erythropoietin. Multivariate regression analysis revealed that neither the serum albumin nor the blood urea nitrogen level independently influenced GA levels. Fasting blood glucose and age were variables that independently influenced GA levels. In contrast, HbA1c was strongly influenced by both erythropoietin dosage and fasting blood glucose. In conclusion, GA is a more useful indicator of glycemic control than HbA1c in diabetic patients with end-stage renal disease.

収録刊行物

  • 糖尿病

    糖尿病 39 (11), 849-855, 1996

    一般社団法人 日本糖尿病学会

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