真空成形法による補助人工心臓用人工弁の製作と改良  [in Japanese] Improvement of fabrication process of vacuum formed valves for ventricular assist device.  [in Japanese]

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Abstract

安価な血液ポンプの供給を目的に作られたKolffの補助人工心臓の原型モデルでは, (1) 流入二尖弁の逆流量が大きい, (2) 流出三尖弁の弁抵抗が大きいという2つの問題があった. その解決法として, (1)射出成形の代わりに真空成形法で二尖弁を製作する方法の検討と, (2) モールドの周囲に高さの異なる円輪を置くことで真空成形時の三尖弁肉厚を調節する方法の検討を行った. その結果, 製作工程の大幅な簡略化と弁特性の向上が実現できた. まず, 二尖弁では臨床用機械弁よりすぐれた水力学的特性が得られ, 新型弁の逆流量は従来の1/6に低減できた. 一方三尖弁では円輪の高さを選択することで0.2mm付近で月難を正確に調節でき, 薄膜弁で弁抵抗が低減できた. 80BPMで14日間の耐久試験も, 試験弁はすべて合格した. 以上, 製品化に向けての基本データが取得できた.

In order to provide an inexpensive ventricular assist device (VAD), we developed a 20mL-VAD which was followed by Prof. Kolffs design, but two problems were found; 1) Big amount of regurgitation through inlet bileaflet valve, 2) High resistance of outlet trileaflet valve. Following trials were carried out to settle them; 1) In the manufacturing process of the bileaflet valve, elastic material was used instead of hard plastic plate. Then, regurgitation could be reduced to 1/6. Moreover, total manufacturing process could be dramatically simplified. 2) In the manufacturing process of the trileaflet valve, leaflet thickness was well controlled around 0.2mm with the aid of a special ring which was located around the valve mold. Then, lower resistance could be achieved by a thin (0.19mm) leaflet valve. Moreover, all valves could be passed the durability testing for 14 days. These data is helpful towards a pre-production stage of the VAD development.

Journal

  • Jinko Zoki

    Jinko Zoki 25(1), 43-47, 1996-02-25

    JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

References:  7

Cited by:  1

Codes

  • NII Article ID (NAID)
    10005626175
  • NII NACSIS-CAT ID (NCID)
    AN00120167
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03000818
  • Data Source
    CJP  CJPref  J-STAGE 
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