骨内歯科インプラント植立実験における牛骨BMP-多孔体アパタイト複合体による顎骨欠損部再生効果について

DOI 被引用文献1件 参考文献32件

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  • Experimental Study on Bone Formation by Porous HAP-BMP Composite in Bone Defect with Osteointegrated Implant

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Hydroxyapatite (HAP) is considered one of the best bioactive ceramics because of high bone conduction/induction in osteogenic tissue. Although it has several characteristics of an ideal bone substitute, it does not have bone induction in heterogenous tissue. On the other hand, partially-purified bone morphogenetic protein (BMP), which contains BMP-2 and can induce differentiation of mesenchymal cells into osteoblast, was extracted from bovine bone matrix. In this study, porous HAP-BMP complex was inserted into the bone defect in case of HAP-coated implant, an integral implant system for the dog mandible.<br/> The results showed significant increases in the height and the area of the new bone in the porous HAP-BMP complex experimental group as compared with the control group. From the results above, it was considered that porous HAP-BMP composite maintains the thickness of regenerated tissue of the bone defect around implant.

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