新しい薬物療法としての核酸医薬

• 森下 竜一

  大阪大学大学院医学系研究科遺伝子治療学

書誌事項

タイトル別名

• Oligonucleotide-based therapy as a potential new pharmacotherapy.
• ダイ14カイ ニホン ヤクリ ガッカイ ガクジュツ ショウレイショウ ジュショウシャ コウエン アタラシイ ヤクブツ リョウホウ ト シテ ノ カクサン イヤク

抄録

Recent progress in molecular biology has provided new techniques to inhibit target gene expression. Especially, the application of DNA technology such as antisense strategy to regulate the transcription of disease-related genes in vivo has important therapeutic potential. Recently, transfection of cis-element double-stranded (ds) oligodeoxynucleotides (ODN) (= decoy) as a powerful tool in a new class of anti-gene strategies for gene therapy and the study of transcriptional regulation has been reported. Transfection of ds ODN corresponding to cis sequence will result in the attenuation of authentic cis-trans interaction, leading to the removal of trans-factors from the endogenous cis-elements with subsequent modulation of gene expression. This “decoy” strategy is not only a novel strategy for gene therapy as an anti-gene strategy, but also a powerful tool for the study of endogenous gene regulation in vivo as well as in vitro. In this article, we reviewed 1) the mechanisms, and 2) potential applications of decoy strategy.

収録刊行物

• 日本薬理学雑誌

  日本薬理学雑誌 115 (3), 123-130, 2000

  公益社団法人 日本薬理学会

キーワード

• デコイ
• 再狭窄
• 遺伝子治療

詳細情報

• CRID: 1390282679248220288
• NII論文ID: 10005705644
• NII書誌ID: AN00198335
• DOI: 10.1254/fpj.115.123
• COI: 1:CAS:528:DC%2BD3cXhsFyjsLo%3D
• ISSN: 13478397
• ISSN: 00155691
• NDL書誌ID: 5291941
• PubMed: 10876797
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5291941
• Web Site: https://search.jamas.or.jp/link/ui/2000121028
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可