Vasodilative Effect of Adrenomedullin in Isolated Arteries of the Dog.

• Nakamura Kumi

  <I>Department of Anesthesia, Kyoto University Hospital</I>

• Toda Hiroshi

  <I>Department of Anesthesia, Kyoto University Hospital</I>

• Terasako Kiyoshi

  <I>Department of Anesthesia, Kyoto University Hospital</I>

• Kakuyama Masahiro

  <I>Department of Anesthesia, Kyoto University Hospital</I>

• Hatano Yoshio

  <I>Department of Anesthesiology , Wakayama Medical College</I>

• Mori Kenjiro

  <I>Department of Anesthesia, Kyoto University Hospital</I>

• Kangawa Kenji

  <I>Department of Biochemistry, National Cardiovascular Center Research Institute</I>

抄録

Adrenomedullin is known to induce profound hypotension in vivo, but the direct effect of this peptide on isolated arteries has not been demonstrated. This study estimated the vasodilative effects of adrenomedullin in comparison with those of calcitonin gene-related peptide (CGRP) in basilar, mesenteric, coronary, renal and femoral arteries isolated from the dog. Adrenomedullin (3 to 100 nM) and CGRP (1 to 30 nM) induced concentration-dependent relaxation of these arteries with and without endothelium, and the relaxing effects were slightly greater in endothelium-intact arteries than in denuded ones. The vasodilative potency of adrenomedullin relative to CGRP was smaller in the femoral artery than in basilar, mesenteric, coronary and renal arteries.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 67 (3), 259-262, 1995

  公益社団法人 日本薬理学会

キーワード

• Adrenomedullin
• Calcitonin gene-related peptide
• Vasodilatation

詳細情報

• CRID: 1390001204286941696
• NII論文ID: 10005710347
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.67.259
• COI: 1:CAS:528:DyaK2MXks1Gjurw%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• PubMed: 7630044
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819355969?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819355969?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1996108218
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可