Participation of Serotonin in Capsaicin-Induced Mouse Ear Edema.
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- Inoue Hideo
- Research Laboratory, Minophagen Pharmaceutical Co.
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- Nagata Nobuyuki
- Research Laboratory, Minophagen Pharmaceutical Co.
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- Koshihara Yasuko
- Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology
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Abstract
We investigated the involvement of serotonin (5-HT) in mouse ear edema induced by topical application of capsaicin (250μg/ear). Application of capsaicin to the ear caused degranulation of mast cells in skin connective tissue. Capsaicin-induced ear edema was significantly inhibited by preadministration of 5-HT2 receptor antagonists such as ketanserin (2 mg/kg, i.v.) and LY 53857 (1 mg/kg, i.v.), but not 5-HT1-, 5-HT3- and 5-HT4-receptor antagonists. Intradermal injection of α-methyl 5-HT (5-HT2-receptor agonist) and 5-HT into ear skin produced edema formation more potently than 8-OH-DPAT (5-HT1A agonist) and 2-methyl 5-HT (5-HT3 agonist). 5-HT2 antagonists markedly suppressed the edema response to 5-HT and its receptor agonists, whereas any antagonist for 5-HT1, 5-HT3 and 5-HT4-receptors had no effect. Furthermore, 5-HT2-receptor antagonists partly prevented ear edema in response to substance P (SP), a putative mediator of capsaicin-induced edema, and compound 48/80, a releaser of vasoactive amines from mast cells. These results suggest that 5-HT released from mast cells is partly involved in the development of capsaicin-induced mouse ear edema via 5-HT2 receptors in the ear skin.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 69 (1), 61-68, 1995
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679263573760
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- NII Article ID
- 10005712329
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2MXot1Gjsbw%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- PubMed
- 8847833
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed