Effect of Terfenadine and KW-4679, a Novel Antiallergic Compound, on Action Potential of Guinea Pig Ventricular Myocytes.

• Ohmori Kenji

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

• Ichimura Michio

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

抄録

It has been reported that terfenadine caused torsade de pointes ventricular arrhythmias. The prolongation of action potential duration (APD) in ventricles is considered to be one of the mechanisms of this adverse effect. We examined the effect of antiallergic drugs, terfenadine and KW-4679 ((Z)-11[3-(dimethylamino)propylidene]-6, 11-dihydrodibenz[b, e]oxepin-2-acetic acid hydrochloride), on action potentials in isolated guinea pig ventricular myocytes. Terfenadine (30 nM-1 μM) increased APD in a concentration-dependent manner. On the other hand, KW-4679 (0.1 μM-100 μM) exerted no significant effects on action potential parameters. These results present no evidence that KW-4679 has the possibility to cause ventricular arrhythmias.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 70 (2), 199-202, 1996

  公益社団法人 日本薬理学会

キーワード

• Antiallergic drug
• Action potential
• Ventricular myocyte

詳細情報

• CRID: 1390001204287511936
• NII論文ID: 10005713593
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.70.199
• COI: 1:CAS:528:DyaK28Xht12rtL4%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• PubMed: 8866759
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819353776?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819353776?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1996145411
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可