Evolution of the Apolipoprotein EReceptor 2 Gene Exon Loss

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Author(s)

Abstract

The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by “exon shuffling.” Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene.

Journal

  • The Journal of Biochemistry

    The Journal of Biochemistry 124(2), 451-456, 1998-08-01

    The Japanese Biochemical Society

References:  28

Codes

  • NII Article ID (NAID)
    10005848864
  • NII NACSIS-CAT ID (NCID)
    AA00694073
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    0021924X
  • NDL Article ID
    4540166
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z53-B472
  • Data Source
    CJP  NDL  J-STAGE 
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